DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nedd4 and Plekha7

DIOPT Version :9

Sequence 1:	NP_648993.1	Gene:	Nedd4 / 39958	FlyBaseID:	FBgn0259174	Length:	1007	Species:	Drosophila melanogaster
Sequence 2:	XP_017177675.1	Gene:	Plekha7 / 233765	MGIID:	2445094	Length:	1359	Species:	Mus musculus

Alignment Length:	214	Identity:	59/214 - (27%)
Similarity:	87/214 - (40%)	Gaps:	50/214 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   529 EPLPPRWSMQVAPNGRTFFIDHASRRTTWIDPRNGRASPMPNQTRRVEDDLGPLPEGWEERVHTD 593
            :.||..||..|..:||.|||:...|.|||:.||.|  .|: |....:..|   ||.||||....:
Mouse     8 DTLPEHWSYGVCRDGRVFFINDQLRCTTWLHPRTG--EPV-NSGHMIRSD---LPRGWEEGFTEE 66

  Fly   594 GRVFYIDHNTRTTQWEDPRLSNPNIAGQAVPYSRDYKQKYEYFKSHIRKP--TNVPNKFEIRIRR 656
            |..|:||||.:||.:..|      :.||....:.:|..:.|. ..|:.||  ...|:..   :..
Mouse    67 GASFFIDHNQQTTTFRHP------VTGQFSSENSEYVLREEP-HPHMSKPERNQRPSSM---VSE 121

  Fly   657 TS---------------ILEDSYRIISSVTKTDLLKTKL--------WVEFEGETGLDYGGLARE 698
            ||               |::.|.::.|...:...::..|        |:..:..:|:..  ..|.
Mouse   122 TSTAGTTSTLEAKPGPKIVKSSSKVHSFGKRDQAIRRNLNVPVVVRGWLHKQDSSGMRL--WKRR 184

  Fly   699 WFYLLSKEMFNPYYGLFEY 717
            ||.|..       |.||.|
Mouse   185 WFVLAD-------YCLFYY 196

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nedd4	NP_648993.1	C2_NEDD4_NEDD4L	71..204	CDD:175999
		WW	248..277	CDD:278809
		WW	531..560	CDD:278809	14/28 (50%)
		WW	581..613	CDD:197736	15/31 (48%)
		HECTc	650..1003	CDD:238033	16/91 (18%)
		HECTc	674..1003	CDD:214523	11/52 (21%)
Plekha7	XP_017177675.1	WW	10..39	CDD:366073	14/28 (50%)
		WW	55..84	CDD:366073	14/28 (50%)
		PH_PEPP1_2_3	158..280	CDD:270068	11/48 (23%)
		Smc	<692..>894	CDD:224117
		PHA03247	<903..1009	CDD:223021
		PRK10263	<912..>1118	CDD:236669
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900