DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nedd4 and NEDD4L

DIOPT Version :9

Sequence 1:	NP_648993.1	Gene:	Nedd4 / 39958	FlyBaseID:	FBgn0259174	Length:	1007	Species:	Drosophila melanogaster
Sequence 2:	XP_006722489.1	Gene:	NEDD4L / 23327	HGNCID:	7728	Length:	1019	Species:	Homo sapiens

Alignment Length:	1059	Identity:	487/1059 - (45%)
Similarity:	628/1059 - (59%)	Gaps:	170/1059 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 DSGDSCHLRIVVLTGQSLAKKDIFGAS--------------------------DPYVRIDLNTIN 103
            |.|:|..||:.|::|..||||||||||                          ||||::.|...:
Human    15 DEGESRILRVKVVSGIDLAKKDIFGASFCSIAVELFFGRDIRKITKCESDNSNDPYVKLSLYVAD 79

  Fly   104 GDINIDSVLTKTKKKTLNPTWNEEFIFRVKPSEHKLVFQVFDENRLTRDDFLGMVELTLVNLPTE 168
            .:..:..|.|||.||||||.|||||.|||.||.|:|:|:||||||||||||||.|::.|.:||||
Human    80 ENRELALVQTKTIKKTLNPKWNEEFYFRVNPSNHRLLFEVFDENRLTRDDFLGQVDVPLSHLPTE 144

  Fly   169 QEGRTIGEQSYT-----LRPRRSVGAKSRIKGTLRIYHAFIRETREQSEPSSGNSDG---EWEHV 225
            ....   |:.||     ||||   ..|||:||.||:..|::.:...|.|.:|...|.   .||.|
Human   145 DPTM---ERPYTFKDFLLRPR---SHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVV 203

  Fly   226 EATNAGETSAQPHPFPTGGHDALPAGWEERQDANGRTYYVNHTARTTQWDRPTVLN-SHSSQSTD 289
            ::.::.....:..|.|     .||.||||:.|..||||||||..|||||.||:::: |..|.:..
Human   204 DSNDSASQHQEELPPP-----PLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNI 263

  Fly   290 DQLASD-----FQRRFHISVD----DTESGRSADSISHNSIEDN--NNAAGLAYTPKTAATSSAP 343
            .|:..:     |:.|.|||.|    .:|.|...:.....|.|.|  .::.|||..|..|:
Human   264 RQINQEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPAS----- 323

  Fly   344 PNTPTNNNGILAQIAMQYRAEEDQDPTVDHTSFVYNSLRHPVAHRQPE--------ISATSLQND 400
            |.:.|:...:..:::.:.:.      |.|.....::||    ..|:|.        ..|.:.|..
Human   324 PGSRTSPQELSEELSRRLQI------TPDSNGEQFSSL----IQREPSSRLRSCSVTDAVAEQGH 378

  Fly   401 LRPVREAPGVPDIAITNPFTRRAAGNMAGG-----------------AGWQQERRRQQMQLHIQQ 448
            |.|    |..       |..|..:..:.||                 :|| :||:..:.:.:...
Human   379 LPP----PSA-------PAGRARSSTVTGGEEPTPSVAYVHTTPGLPSGW-EERKDAKGRTYYVN 431

  Fly   449 HQQRQQQQQQNRILLDVD----------HRQQEPQHR-----------------GQRHQQQHRPS 486
            |..|.....:..:.|..|          :...|||.|                 |.:.....|..
Human   432 HNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAV 496

  Fly   487 NEDTDHTDSHNPSDISAPSTRRNSEEDNAAVPPMEQNTGGEEEPLPPRWSMQVAPNGRTFFIDHA 551
            .:...:..|..||..::|.             |..:.|   :..|||.|.|::|||||.|||||.
Human   497 KDTLSNPQSPQPSPYNSPK-------------PQHKVT---QSFLPPGWEMRIAPNGRPFFIDHN 545

  Fly   552 SRRTTWIDPRNGRASPMPNQTRRVEDDLGPLPEGWEERVHTDGRVFYIDH--------------- 601
            ::.|||.|||......|.::|....:||||||.|||||:|.|||.|||||
Human   546 TKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERIHLDGRTFYIDHSSQVLCGENDTRESV 610

  Fly   602 ---NTRTTQWEDPRLSNPNIAGQAVPYSRDYKQKYEYFKSHIRKPTNVPNKFEIRIRRTSILEDS 663
               :::.||||||||.||.|.|.||||||::||||:||:..::||.::||:||:::.|.:|.|:|
Human   611 PSYDSKITQWEDPRLQNPAITGPAVPYSREFKQKYDYFRKKLKKPADIPNRFEMKLHRNNIFEES 675

  Fly   664 YRIISSVTKTDLLKTKLWVEFEGETGLDYGGLAREWFYLLSKEMFNPYYGLFEYSAMDNYTLQIN 728
            ||.|.||.:.|:||.:||:|||.|.||||||:|||||:||||||||||||||||||.||||||||
Human   676 YRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQIN 740

  Fly   729 NGSGLCNEEHLSYFKFIGRIAGMAVYHGKLLDAFFIRPFYKMMLQKPIDLKDMESVDTEYYNSLM 793
            ..||||||:|||||.||||:||:||:||||||.|||||||||||.|.|.|.||||||:||||||.
Human   741 PNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLK 805

  Fly   794 WIKENDPRILELTFCLDEDVFGQKSQHELKPGGANIDVTNENKDEYIKLVIEWRFVARVKEQMSS 858
            ||.||||..|:|.||:||:.|||..|.:|||.|:.|.||||||.|||.|||:||||.||::||::
Human   806 WILENDPTELDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNA 870

  Fly   859 FLDGFGSIIPLNLIKIFDEHELELLMCGIQNIDVKDWRENTLYKGDYHMNHIIIQWFWRAVLSFS 923
            ||:||..::|::|||||||:||||||||:.::||.|||::::||..|..||.:|||||:|||...
Human   871 FLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMD 935

  Fly   924 NEMRSRLLQFVTGTSRVPMNGFKELYGSNGPQMFTIEKWGTPNNFPRAHTCFNRLDLPPYEGYLQ 988
            .|.|.|||||||||||||||||.|||||||||:||||:||:|...||||||||||||||||.:..
Human   936 AEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFED 1000

  Fly   989 LKDKLIKAIEGSQGFAGVD 1007
            |::||:.|:|.:|||.|||
Human  1001 LREKLLMAVENAQGFEGVD 1019

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nedd4	NP_648993.1	C2_NEDD4_NEDD4L	71..204	CDD:175999	77/163 (47%)
		WW	248..277	CDD:278809	20/28 (71%)
		WW	531..560	CDD:278809	18/28 (64%)
		WW	581..613	CDD:197736	23/49 (47%)
		HECTc	650..1003	CDD:238033	244/352 (69%)
		HECTc	674..1003	CDD:214523	233/328 (71%)
NEDD4L	XP_006722489.1	C2_NEDD4_NEDD4L	21..179	CDD:175999	77/163 (47%)
		WW	224..250	CDD:278809	18/25 (72%)
		WW	413..442	CDD:278809	6/29 (21%)
		WW	526..556	CDD:238122	19/29 (66%)
		WW	575..625	CDD:197736	23/49 (47%)
		HECTc	662..1016	CDD:238033	245/353 (69%)
		HECTc	686..1015	CDD:214523	233/328 (71%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	471	1.000	Domainoid score	I454
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H86986
Inparanoid	1	1.050	884	1.000	Inparanoid score	I398
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49869
OrthoDB	1	1.010	-	-		D142537at33208
OrthoFinder	1	1.000	-	-		FOG0000080
OrthoInspector	1	1.000	-	-		otm41627
orthoMCL	1	0.900	-	-		OOG6_100256
Panther	1	1.100	-	-	O	PTHR11254
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2273
SonicParanoid	1	1.000	-	-		X1682
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.870