DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Nedd4 and HECW1

DIOPT Version :9

Sequence 1:NP_648993.1 Gene:Nedd4 / 39958 FlyBaseID:FBgn0259174 Length:1007 Species:Drosophila melanogaster
Sequence 2:XP_016867371.1 Gene:HECW1 / 23072 HGNCID:22195 Length:1639 Species:Homo sapiens


Alignment Length:953 Identity:296/953 - (31%)
Similarity:416/953 - (43%) Gaps:269/953 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   212 EPSSGNSDGEWE--------HVEATNAGETS------------------AQP-----------HP 239
            :|.|.|..|.|:        |||.:..|..|                  :||           |.
Human   792 DPESTNGAGPWQDELAAPSGHVERSPEGLESPVAGPSNRREGECPILHNSQPVSQLPSLRPEHHH 856

  Fly   240 FPTGGHDALPAGWEERQDANGRTYYVNHTARTTQWDRPTVLNSHSS--QSTDDQLASDFQRRFHI 302
            :|| ..:.||..||.|.|::||.:||:|..|||.|.|||...:...  :|...|......||:..
Human   857 YPT-IDEPLPPNWEARIDSHGRVFYVDHVNRTTTWQRPTAAATPDGMRRSGSIQQMEQLNRRYQN 920

  Fly   303 SVDDTESGRSADSISHNSIEDNNNAAGLAYTPKTAATSSAPPNTPTNNNGILAQIAMQYRAEEDQ 367
            ......:.||.:.....|.|......|......:.|.||              |.::..|.|...
Human   921 IQRTIATERSEEDSGSQSCEQAPAGGGGGGGSDSEAESS--------------QSSLDLRREGSL 971

  Fly   368 DPTVDHTSFVYNSLRHPVAHRQPEISATSLQNDLRPVREAPGVPDIAITNP--FTRRAAGNMAGG 430
            .|.        ||.:..:..:.|.:.                    .||||  ||...| |.:..
Human   972 SPV--------NSQKITLLLQSPAVK--------------------FITNPEFFTVLHA-NYSAY 1007

  Fly   431 AGWQQERRRQQMQLHIQQHQQRQQQQQQNRILLD-----VDHRQQEPQHRGQRHQQQHRPSNEDT 490
            ..:......:.|.|.:::..:..::.|.||.|::     .|.|.:                    
Human  1008 RVFTSSTCLKHMILKVRRDARNFERYQHNRDLVNFINMFADTRLE-------------------- 1052

  Fly   491 DHTDSHNPSDISAPSTRRNSEEDNAAVPPMEQNTGGEEEPLPPRWSMQVAPNGRTFFIDHASRRT 555
                                                    ||..|.::....|::||:||.||.|
Human  1053 ----------------------------------------LPRGWEIKTDQQGKSFFVDHNSRAT 1077

  Fly   556 TWIDPR----NGRASPMPN-----------------QTRRVEDDLG------------------- 580
            |:||||    |||   :||                 :...|..:.|                   
Human  1078 TFIDPRIPLQNGR---LPNHLTHRQHLQRLRSYSAGEASEVSRNRGASLLARPGHSLVAAIRSQH 1139

  Fly   581 ---PLPEGWEERV-----------------------HT-DGRVFYI----DHNTRTTQWE----- 609
               .||..:.:::                       || ..::.||    :|.......:     
Human  1140 QHESLPLAYNDKIVAFLRQPNIFEMLQERQPSLARNHTLREKIHYIRTEGNHGLEKLSCDADLVI 1204

  Fly   610 -------------------------DPRLS-------NPNI----AGQAVPYSRDYKQKYE--YF 636
                                     .||.|       :|.:    |....||.||::.|..  |.
Human  1205 LLSLFEEEIMSYVPLQAAFHPGYSFSPRCSPCSSPQNSPGLQRASARAPSPYRRDFEAKLRNFYR 1269

  Fly   637 KSHIRKPTNVPNKFEIRIRRTSILEDSYRIISSVTKTDLLKTKLWVEFEGETGLDYGGLAREWFY 701
            |...:.....|.|.::.|||..:||.::..:.:.::.:|.:.||:|.|.||.||||.|.:||:|:
Human  1270 KLEAKGFGQGPGKIKLIIRRDHLLEGTFNQVMAYSRKELQRNKLYVTFVGEEGLDYSGPSREFFF 1334

  Fly   702 LLSKEMFNPYYGLFEYSAMDNYTLQINNGSGLCNEEHLSYFKFIGRIAGMAVYHGKLLDAFFIRP 766
            |||:|:||||||||||||.|.||:||:..|... |.||.:|:|.|||.|:|:.|..||||||.||
Human  1335 LLSQELFNPYYGLFEYSANDTYTVQISPMSAFV-ENHLEWFRFSGRILGLALIHQYLLDAFFTRP 1398

  Fly   767 FYKMMLQKPIDLKDMESVDTEYYNSLMWIKEND-PRILELTFCLDEDVFGQKSQHELKPGGANID 830
            |||.:|:.|.||.|:|.:|.|::.||.|:|:|: ..||:|||.::|:||||.::.|||.||||..
Human  1399 FYKALLRLPCDLSDLEYLDEEFHQSLQWMKDNNITDILDLTFTVNEEVFGQVTERELKSGGANTQ 1463

  Fly   831 VTNENKDEYIKLVIEWRFVARVKEQMSSFLDGFGSIIPLNLIKIFDEHELELLMCGIQNIDVKDW 895
            ||.:||.|||:.:::||....|.:|..:.:.||..::...|:.:||..||||::.|...||:.||
Human  1464 VTEKNKKEYIERMVKWRVERGVVQQTEALVRGFYEVVDSRLVSVFDARELELVIAGTAEIDLNDW 1528

  Fly   896 RENTLYKGDYHMNHIIIQWFWRAVLSFSNEMRSRLLQFVTGTSRVPMNGFKELYGSNGPQMFTIE 960
            |.||.|:|.||..|::|:|||.||..|:||.|.||||||||||.||..||..|.||||.:.|.||
Human  1529 RNNTEYRGGYHDGHLVIRWFWAAVERFNNEQRLRLLQFVTGTSSVPYEGFAALRGSNGLRRFCIE 1593

  Fly   961 KWGTPNNFPRAHTCFNRLDLPPYEGYLQLKDKLIKAIEGSQGF 1003
            |||...:.|||||||||||||||..|..|.:||:.|:|.:..|
Human  1594 KWGKITSLPRAHTCFNRLDLPPYPSYSMLYEKLLTAVEETSTF 1636

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Nedd4NP_648993.1 C2_NEDD4_NEDD4L 71..204 CDD:175999
WW 248..277 CDD:278809 15/28 (54%)
WW 531..560 CDD:278809 13/28 (46%)
WW 581..613 CDD:197736 8/89 (9%)
HECTc 650..1003 CDD:238033 183/353 (52%)
HECTc 674..1003 CDD:214523 178/329 (54%)
HECW1XP_016867371.1 None
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000080
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.810

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