Protein Alignment Nedd4 and Hectd2

DIOPT Version :10

• Sequence 1: NP_648993.1
• Gene: Nedd4 / 39958
• FlyBaseID: FBgn0259174
• Length: 1007
• Species: Drosophila melanogaster
• Sequence 2: NP_001156943.1
• Gene: Hectd2 / 226098
• MGIID: 2442663
• Length: 775
• Species: Mus musculus
• Alignment Length: 941
• Identity: 220/941 - (23%)
• Similarity: 344/941 - (36%)
• Gaps: 292/941 - (31%)

  Fly   166 PTEQEGRTIGEQSYTLRPRRSVGAKSRI----KGTLRIYHAFIRETREQSEPSSGNSDGEWEHVE 226
            |.|::|:.  .:...|.|..:.||.:.:    ||.:..:.:|:....::.|.:...|..  .|:.
Mouse    21 PEERKGKE--PEREKLPPIVTAGAAAGLDRGSKGQISTFSSFVSTVTQKKEAAENRSSP--THLA 81

  Fly   227 ATN-------------------------AGETSAQPHPFPTGGHDALPA------GWE---ERQD 257
            ..|                         ..|....|.|.|     :||:      .:|   |:.:
Mouse    82 LPNIRNVRDLPPICLDVRQKQRMSVEALPSEVKVPPLPEP-----SLPSQPKTVKDFEEDLEKAE 141

  Fly   258 ANGRTYYVNHTARTTQWDRPTVLNSHSSQSTDDQLASDFQRRFHISVDDTESGRSADSISHNSIE 322
            |.|....| |....|.:|..|.||:...:..                          :.|.|:||
Mouse   142 ATGNWKTV-HAFYITAFDSFTELNTAFKKDA--------------------------TASFNTIE 179

  Fly   323 DNNNAAGLAYTPKTAATSSAPPNTPTN-----NNGILAQIAMQYRAEEDQDPTVDHTSFVYNSLR 382
            |:...|.|     ..|...|..|||.:     ..||:..:..:::....:|..  ...|:.
Mouse   180 DSGLNANL-----VNAVFDALLNTPQDIQKSVLKGIINSLLQEWKGPRTKDDL--RAYFIL---- 233

  Fly   383 HPVAHRQPEISATSLQNDLRPVREAPGVPDIAITNPFTRRAAGNMAGGAGWQQERRRQQMQLHIQ 447
                          |||           |...||:.:.                         |.
Mouse   234 --------------LQN-----------PQFNITSTYV-------------------------IY 248

  Fly   448 QHQQRQQQQQQNRILLDVDHRQQEPQHRGQRHQQQHRPSNEDTDHTDSHNPSDISAPSTRRNSEE 512
            .|..|     |...|::.||                        |...|....:|....::
Mouse   249 AHLLR-----QIATLVEADH------------------------HFLVHWLKKLSQKKFKQ---- 280

  Fly   513 DNAAVPPMEQNTG-----GEEEPLPPRWSMQVAPNGRTFFIDHASRRTTWIDPRNGRASPMPNQT 572
               .|..:.|...     .:.|..||....       |::|..|::....::..|....|
Mouse   281 ---LVERLLQFVSLRLFPAKPEEFPPLTKC-------TWWIPSAAKVLALLNTANNLVHP----- 330

  Fly   573 RRVEDDLGPLPEGWEERVHTDGRVFY---IDHNTRTTQ---WEDPRLSNP-----------NIAG 620
                    ||..      :||   ||   :||.....:   |:....|:.           :||.
Mouse   331 --------PLVP------YTD---FYNSTLDHIDLMEEYHTWQSFGNSHSRFSFCQYPFVISIAA 378

  Fly   621 QAVPYSRDYKQKYEYFK--------SHIRKPTNVPNKFEIRIRRTSILEDSYRIISSVT-KTDLL 676
            :.:...||.:|:.....        |..::|........:::|||.::.||   :..:| |...|
Mouse   379 KKIIIQRDSEQQMISIARQSLVDKVSRRQRPDMNMLFLNMKVRRTHLVSDS---LDELTRKRADL 440

  Fly   677 KTKLWVEFEGETGLDYGGLAREWFYLLSKEMFNPYYGLFEYS-----------AMDNYTLQINNG 730
            |.||.|.|.||.|||.|||.:|||.||.:::|:|.||:|.|.           ..|||
Mouse   441 KKKLKVTFVGEAGLDMGGLTKEWFLLLIRQIFHPDYGMFTYHKDSHCHWFSSFKCDNY------- 498

  Fly   731 SGLCNEEHLSYFKFIGRIAGMAVYHGKLLDAFFIRPFYKMMLQKP--------------IDLKDM 781
                     |.|:.:|.:.|:|||:...||..|....||.:|..|              :.:.|:
Mouse   499 ---------SEFRLVGILMGLAVYNSITLDIRFPPCCYKKLLSPPVVPSDQSTPVGICSVTIDDL 554

  Fly   782 ESVDTEYYNSLMWIKENDPRILE---LTFCLDEDVFGQKSQHELKPGGANIDVTNENKDEYIKLV 843
            ..|..|..:.|..:...:..:.|   .||.:.::.||....:.|||||..|.|||:|:.||::|.
Mouse   555 CQVMPELAHGLKELLSYEGNVEEDFYSTFQVFQEEFGVIKSYNLKPGGDKIPVTNQNRREYVQLY 619

  Fly   844 IEWRFVARVKEQMSSFLDGFGSIIPLNLIKIFDEHELELLMCGIQNIDVKDWRENTLYKGDYHMN 908
            .::.....:.:|.::|..||.|:...|.:.:....|:|:|:||...:|:...:.:|.|.| |...
Mouse   620 TDFLLNKSIYKQFAAFYCGFHSVCASNALMLLRPEEVEILVCGSPELDMHALQRSTQYDG-YAKT 683

  Fly   909 HIIIQWFWRAVLSFSNEMRSRLLQFVTGTSRVPMNGFKELYGSNGPQMFTIEKWGTPNNF-PRAH 972
            .:.|::||..||.|..|::.:||.|.||:.|||:.|..:|       .|.|.|..|..|: |.||
Mouse   684 DLTIRYFWDVVLGFPLELQKKLLHFTTGSDRVPVGGMADL-------NFKISKNETSTNWLPVAH 741

  Fly   973 TCFNRLDLPPYEGYLQLKDKLIKAIEGSQGF 1003
            ||||:|.||||:....||.|||..|..|:||
Mouse   742 TCFNQLCLPPYKSKKDLKQKLIIGISNSEGF 772

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nedd4	NP_648993.1	C2_NEDD4_NEDD4L	71..204	CDD:175999	9/41 (22%)
		WW	248..277	CDD:459800	10/37 (27%)
		HUL4	<523..1003	CDD:227354	153/539 (28%)
Hectd2	NP_001156943.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..51		7/31 (23%)
		HECTc	416..773	CDD:238033	130/384 (34%)