DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nedd4 and Yap1

DIOPT Version :9

Sequence 1:	NP_648993.1	Gene:	Nedd4 / 39958	FlyBaseID:	FBgn0259174	Length:	1007	Species:	Drosophila melanogaster
Sequence 2:	XP_006509915.1	Gene:	Yap1 / 22601	MGIID:	103262	Length:	494	Species:	Mus musculus

Alignment Length:	310	Identity:	77/310 - (24%)
Similarity:	116/310 - (37%)	Gaps:	80/310 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   337 AATSSAPPNTPTNNNGILAQIAMQYRAEEDQDPTVDHTSFVYNSLRHPVAHRQPEISATSLQNDL 401
            |.|.:|||..|..:.      .:..|.:.:.|     ...::|::.:|.....|:.....|:.
Mouse    24 AGTPAAPPAPPAGHQ------VVHVRGDSETD-----LEALFNAVMNPKTANVPQTVPMRLRK-- 75

  Fly   402 RPVREAPGVPDIAITNPFTR---RAAGNMAGGAGWQQERRRQQMQLHIQQHQQRQQQQQQNRILL 463
                    :||.....|..:   |.|...||.||....:       |::.|......|     |.
Mouse    76 --------LPDSFFKPPEPKSHSRQASTDAGTAGALTPQ-------HVRAHSSPASLQ-----LG 120

  Fly   464 DVDHRQQEPQHRGQRHQQQHRPSNEDTDHTDSHNPSDISAPSTRRNSEEDNAAVPPMEQNTGGEE 528
            .|.                  |.........|...:..:|...|::|.|    :|        ::
Mouse   121 AVS------------------PGTLTASGVVSGPAAAPAAQHLRQSSFE----IP--------DD 155

  Fly   529 EPLPPRWSMQVAPNGRTFFIDHASRRTTWIDPRNGR---------ASPMPNQTRRVEDDLGPLPE 584
            .|||..|.|....:|:.:|::|..:.|||.|||...         |||...|| .:....||||:
Mouse   156 VPLPAGWEMAKTSSGQRYFLNHNDQTTTWQDPRKAMLSQLNVPAPASPAVPQT-LMNSASGPLPD 219

  Fly   585 GWEERVHTDGRVFYIDHNTRTTQWEDPRLSNPNIA---GQAVPYSRDYKQ 631
            |||:.:..||.|:||:|..:||.|.|||| :|...   .|.:..|...||
Mouse   220 GWEQAMTQDGEVYYINHKNKTTSWLDPRL-DPRFGKAMNQRITQSAPVKQ 268

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nedd4	NP_648993.1	C2_NEDD4_NEDD4L	71..204	CDD:175999
		WW	248..277	CDD:278809
		WW	531..560	CDD:278809	10/28 (36%)
		WW	581..613	CDD:197736	17/31 (55%)
		HECTc	650..1003	CDD:238033
		HECTc	674..1003	CDD:214523
Yap1	XP_006509915.1	FAM181	<61..>141	CDD:373671	18/119 (15%)
		WW	159..188	CDD:238122	10/28 (36%)
		WW	217..246	CDD:366073	14/28 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900