Protein Alignment Nedd4 and Ube3a

DIOPT Version :9

• Sequence 1: NP_648993.1
• Gene: Nedd4 / 39958
• FlyBaseID: FBgn0259174
• Length: 1007
• Species: Drosophila melanogaster
• Sequence 2: NP_001380595.1
• Gene: Ube3a / 22215
• MGIID: 105098
• Length: 870
• Species: Mus musculus
• Alignment Length: 962
• Identity: 220/962 - (22%)
• Similarity: 371/962 - (38%)
• Gaps: 233/962 - (24%)

  Fly   171 GRTIGEQSYTLRPRRSVGAKSRIKGTLRIYHAFIRE------TRE--QSEPSSGNSDGEWEHVEA 227
            |.:..|.....|.:|: .||..|:   |.||.....      |.|  .|.|:....|.....::|
Mouse    10 GESQSEDIEASRMKRA-AAKHLIE---RYYHQLTEGCGNEACTNEFCASCPTFLRMDNNAAAIKA 70

  Fly   228 TNAGETSAQ---PHPFPTGGHDA-------------LPAGWEERQD-------ANGRTYYVNHTA 269
            ....:.:|:   |||...|...|             :....:|.:|       ...:.|.:....
Mouse    71 LELYKINAKLCDPHPSKKGASSAYLENSKGASNNSEIKMNKKEGKDFKDVIYLTEEKVYEIYEFC 135

  Fly   270 RTTQWDRPTVLNSHSSQSTDDQLASDFQRRFHISVDDTESGRSADSISHNSIEDNNNAAGLAYTP 334
            |.::...|.:.......|:.:.|...|::....:.::.:|.:..|.......::....:..|...
Mouse   136 RESEDYSPLIRVIGRIFSSAEALVLSFRKVKQHTKEELKSLQEKDEDKDEDEKEKAACSAAAMEE 200

  Fly   335 KTAATSSAPPNTPTNNNGILAQIAMQYRAEEDQDPTVDHTSFVYNSLRHPVAHRQPEISATSLQN 399
            .:.|:||...::...:|.:      |....:|....:|....||:||   :|:.:.|   |:..|
Mouse   201 DSEASSSRMGDSSQGDNNV------QKLGPDDVTVDIDAIRRVYSSL---LANEKLE---TAFLN 253

  Fly   400 DLRPVREAPGVP-DIAITNPFTR---------------------------------------RAA 424
            .|  |..:|.|. |:...|.:||                                       .|.
Mouse   254 AL--VYLSPNVECDLTYHNVYTRDPNYLNLFIIVMENSNLHSPEYLEMALPLFCKAMCKLPLEAQ 316

  Fly   425 GNMAG-GAGWQQERRRQQMQLHIQ---------QHQQRQQQQQQNRIL----------------- 462
            |.:.. .:.:..::.|:.|:...|         :...|......:.|:
Mouse   317 GKLIRLWSKYSADQIRRMMETFQQLITYKVISNEFNSRNLVNDDDAIVAASKCLKMVYYANVVGG 381

  Fly   463 -LDVDHRQQEPQHRGQRHQQQHRPSNEDTDHTDSHNPSDISAPSTRRNSEEDNAAVPPMEQNTGG 526
             :|.:|.:::.:          .|..|.::.|......|     .|||.:  ...|.|:|...|.
Mouse   382 DVDTNHNEEDDE----------EPIPESSELTLQELLGD-----ERRNKK--GPRVDPLETELGV 429

  Fly   527 E---------------EEPLPPRWSMQVAPNGRTFFIDHASRRTTWIDPRNGRASPMPNQTRRVE 576
            :               .|||.....|.   ...|||......:.:::        ..|.....|.
Mouse   430 KTLDCRKPLISFEEFINEPLNDVLEMD---KDYTFFKVETENKFSFM--------TCPFILNAVT 483

  Fly   577 DDLGPLPEGWEERVHTDGRVFYIDHNTRTTQWEDPRLS--NPNIAGQAV-PYSRDYKQKYEYFKS 638
            .:||                .|.|:..|  .:.:.|::  ...:.||.: ||.|
Mouse   484 KNLG----------------LYYDNRIR--MYSERRITVLYSLVQGQQLNPYLR----------- 519

  Fly   639 HIRKPTNVPNKFEIRIRRTSILEDS---YRIISSVTKTDLLKTKLWVEFEGETGLDYGGLAREWF 700
                         :::||..|::|:   ..:|:.....| ||.:|:||||||.|:|.||:::|:|
Mouse   520 -------------LKVRRDHIIDDALVRLEMIAMENPAD-LKKQLYVEFEGEQGVDEGGVSKEFF 570

  Fly   701 YLLSKEMFNPYYGLFEYSAMDNYT-LQINNGSGLCNEEHLSYFKFIGRIAGMAVYHGKLLDAFFI 764
            .|:.:|:|||..|:|.|   |..| |...|.|....|   ..|..||.:.|:|:|:..:||..|.
Mouse   571 QLVVEEIFNPDIGMFTY---DEATKLFWFNPSSFETE---GQFTLIGIVLGLAIYNNCILDVHFP 629

  Fly   765 RPFYKMMLQKPIDLKDMESVDTEYYNSLMWIKENDPRI---LELTFCLDE-DVFGQKSQHELKPG 825
            ...|:.::.|....:|:.......|.||..:.|.:..:   :.:||.:.: |:||....::||..
Mouse   630 MVVYRKLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGSVEDDMMITFQISQTDLFGNPMMYDLKEN 694

  Fly   826 GANIDVTNENKDEYIKLVIEWRFVARVKEQMSSFLDGFGSIIPLNLIK-IFDEHELELLMCGIQN 889
            |..|.:||||:.|::.|..::.....|::|..:|..||..:...:.:| :|...|:|||:||.:|
Mouse   695 GDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIELLICGSRN 759

  Fly   890 IDVKDWRENTLYKGDYHMNHIIIQWFWRAVLSFSNEMRSRLLQFVTGTSRVPMNG---FKELYGS 951
            :|.:...|.|.|.|.|....::|:.||..|.||::|.:...|||.|||.|.|:.|   .|.:...
Mouse   760 LDFQALEETTEYDGGYTRESVVIREFWEIVHSFTDEQKRLFLQFTTGTDRAPVGGLGKLKMIIAK 824

  Fly   952 NGPQMFTIEKWGTPNNFPRAHTCFNRLDLPPYEGYLQLKDKLIKAIEGSQGF 1003
            |||.         ....|.:|||||.|.||.|....:||::|:|||..::||
Mouse   825 NGPD---------TERLPTSHTCFNVLLLPEYSSKEKLKERLLKAITYAKGF 867

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nedd4	NP_648993.1	C2_NEDD4_NEDD4L	71..204	CDD:175999	10/32 (31%)
		WW	248..277	CDD:278809	4/35 (11%)
		WW	531..560	CDD:278809	5/28 (18%)
		WW	581..613	CDD:197736	3/31 (10%)
		HECTc	650..1003	CDD:238033	122/364 (34%)
		HECTc	674..1003	CDD:214523	117/337 (35%)
Ube3a	NP_001380595.1	AZUL	27..81	CDD:406862	13/56 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	171..223		8/57 (14%)
		HECTc	518..868	CDD:238033	125/390 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810