DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nedd4 and Hace1

DIOPT Version :9

Sequence 1:	NP_648993.1	Gene:	Nedd4 / 39958	FlyBaseID:	FBgn0259174	Length:	1007	Species:	Drosophila melanogaster
Sequence 2:	XP_006512697.1	Gene:	Hace1 / 209462	MGIID:	2446110	Length:	921	Species:	Mus musculus

Alignment Length:	392	Identity:	166/392 - (42%)
Similarity:	228/392 - (58%)	Gaps:	20/392 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   626 SRDYKQKYEYFKSH----------IRKPTNVPNKFEIRIRRTSILEDSYRIISSVTKTDLLKTKL 680
            ::.:|.:.|:|..|          :.:|  |.....:.:.|.||...|..|:|...... ||..:
Mouse   533 AQPFKDRCEWFYEHLHSGQPDSDMVHRP--VSENDILLVHRDSIFRSSCEIVSKANCAK-LKQGI 594

  Fly   681 WVEFEGETGLDYGGLAREWFYLLSKEMFNPYYGLFEYSAMDNYTLQINNGSGLCNEEHLSYFKFI 745
            .|.|.||.|:.. |:.||||.:||.|:.||.|.||..|| |..|.|.|:.| ..|.:||:||:|.
Mouse   595 AVRFHGEEGMGQ-GVVREWFDILSNEIVNPDYALFTQSA-DGTTFQPNSNS-YVNPDHLNYFRFA 656

  Fly   746 GRIAGMAVYHGKLLDAFFIRPFYKMMLQKPIDLKDMESVDTEYYNSLMWIKEND--PRILELTFC 808
            |:|.|:|:.|.:|::.:|.|.|||.:|..|::.:|:.|:|.||..:|.||.:||  ...|||||.
Mouse   657 GQILGLALNHRQLVNIYFTRSFYKHILGIPVNYQDVASIDPEYAKNLQWILDNDISDLGLELTFS 721

  Fly   809 LDEDVFGQKSQHELKPGGANIDVTNENKDEYIKLVIEWRFVARVKEQMSSFLDGFGSIIPLNLIK 873
            ::.||||...:..|||||.:|.||..||.||::||.|.|....::.|:::||.||...||.:||:
Mouse   722 VETDVFGAMEEVPLKPGGGSILVTQNNKAEYVQLVTELRMTRAIQPQINAFLQGFHMFIPPSLIQ 786

  Fly   874 IFDEHELELLMCGIQNIDVKDWRENTLYKGDYHMNHIIIQWFWRAVLSFSNEMRSRLLQFVTGTS 938
            :|||:|||||:.|:..|||.||.:||.|...|.....:|||||..|...:.|.|..|||||||:|
Mouse   787 LFDEYELELLLSGMPEIDVNDWIKNTEYTSGYEREDPVIQWFWEVVEDITQEERVLLLQFVTGSS 851

  Fly   939 RVPMNGFKELYGSNGPQMFTIEKWG-TPNNFPRAHTCFNRLDLPPYEGYLQLKDKLIKAIE-GSQ 1001
            |||..||..:.|.:|.|.|||.... |||..|.:.||.|.|.||.|.....|||:|:.|:. ||.
Mouse   852 RVPHGGFANIMGGSGLQNFTIAAVPYTPNLLPTSSTCINMLKLPEYPSKEILKDRLLVALHCGSY 916

  Fly  1002 GF 1003
            |:
Mouse   917 GY 918

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nedd4	NP_648993.1	C2_NEDD4_NEDD4L	71..204	CDD:175999
		WW	248..277	CDD:278809
		WW	531..560	CDD:278809
		WW	581..613	CDD:197736
		HECTc	650..1003	CDD:238033	159/356 (45%)
		HECTc	674..1003	CDD:214523	153/332 (46%)
Hace1	XP_006512697.1	ANK repeat	66..95	CDD:293786
		Ank_2	69..194	CDD:372319
		ANK repeat	97..128	CDD:293786
		ANK repeat	130..161	CDD:293786
		ANK repeat	163..194	CDD:293786
		Ank_2	168..263	CDD:372319
		ANK repeat	196..233	CDD:293786
		HECTc	566..915	CDD:238033	157/352 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000080
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810