DRSC/TRiP Functional Genomics Resources

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Protein Alignment Nedd4 and Nedd4

DIOPT Version :9

Sequence 1:NP_648993.1 Gene:Nedd4 / 39958 FlyBaseID:FBgn0259174 Length:1007 Species:Drosophila melanogaster
Sequence 2:NP_001344927.1 Gene:Nedd4 / 17999 MGIID:97297 Length:1207 Species:Mus musculus


Alignment Length:890 Identity:416/890 - (46%)
Similarity:506/890 - (56%) Gaps:191/890 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly   150 TRDDFLGMVELTLVNLPTEQEGRTIGEQSYT-----LRPRRSVGAKSRIKGTLRIYHAFIRETRE 209
            |||||||.|::.|..||||....   |:.||     |.||   ..|||:||.||:...::     
Mouse   477 TRDDFLGQVDVPLYPLPTENPRM---ERPYTFKDFVLHPR---SHKSRVKGYLRLKMTYL----- 530

  Fly   210 QSEPSSGNSDGEWEHVEATNAG--------ETSAQPHPFPTGGHDALPAGWEERQDANGRTYYVN 266
               |.:|:.|...:..|....|        ..:..||| |.  ...||.|||||||..|||||||
Mouse   531 ---PKNGSEDENADQAEELEPGWVVLDQPDAATHLPHP-PE--PSPLPPGWEERQDVLGRTYYVN 589

  Fly   267 HTARTTQWDRPTVLNSHSSQSTDDQLASDFQRRFHISVDDTESGRSADSISHNSIEDNNNAAGLA 331
            |.:|.|||.||         |.||.|..                           |||::..   
Mouse   590 HESRRTQWKRP---------SPDDDLTD---------------------------EDNDDMQ--- 615

  Fly   332 YTPKTAATSSAPPNTPTNNNGILAQIAMQYRAEEDQDPTVDHTSFVYNSLRHPVAHRQPEISATS 396
                                 :.||.|...|.:..:|                            
Mouse   616 ---------------------LQAQRAFTTRRQISED---------------------------- 631

  Fly   397 LQNDLRPVREAPGVPDIAITNPFTRRAAGNMAGGAGWQQERRRQQMQLHIQQHQQRQQQQQQNRI 461
                              :..|..|.:..|      |:..|..:..:...|..|......     
Mouse   632 ------------------VDGPDNRESPEN------WEIVREDENTEYSGQAVQSPPSGH----- 667

  Fly   462 LLDVDHRQQEPQHRGQRHQQQHRPSNEDTDHTDSHNPSDISAPSTRRNSE-----------EDNA 515
             :||               |.|.....:|......||: .|.|.|..|..           |:..
Mouse   668 -IDV---------------QTHLAEEFNTRLAVCGNPA-TSQPVTSSNHSSRGGSLQTCIFEEQP 715

  Fly   516 AVPPMEQNTGGEEEPLPPRWSMQVAPNGRTFFIDHASRRTTWI------DPRNGRASPMPNQTRR 574
            .:|.:...:.|    |||.|..:....||::::||.|:.|||.      |||    |.:|...|.
Mouse   716 TLPVLLPTSSG----LPPGWEEKQDDRGRSYYVDHNSKTTTWSKPTMQDDPR----SKIPAHLRG 772

  Fly   575 VED--DLGPLPEGWEERVHTDGRVFYIDHNTRTTQWEDPRLSNPNIAGQAVPYSRDYKQKYEYFK 637
            ..|  ||||||.|||||.|||||||:|:||.:.||||||||.|..|.|.|||||||||:|||:|:
Mouse   773 KTDSNDLGPLPPGWEERTHTDGRVFFINHNIKKTQWEDPRLQNVAITGPAVPYSRDYKRKYEFFR 837

  Fly   638 SHIRKPTNVPNKFEIRIRRTSILEDSYRIISSVTKTDLLKTKLWVEFEGETGLDYGGLAREWFYL 702
            ..::|.|::|||||:::||.:|||||||.|..|.:.||||.:||:||:||.||||||:|||||:|
Mouse   838 RKLKKQTDIPNKFEMKLRRANILEDSYRRIMGVKRADLLKARLWIEFDGEKGLDYGGVAREWFFL 902

  Fly   703 LSKEMFNPYYGLFEYSAMDNYTLQINNGSGLCNEEHLSYFKFIGRIAGMAVYHGKLLDAFFIRPF 767
            :||||||||||||||||.||||||||..||||||:||||||||||:||||||||||||.||||||
Mouse   903 ISKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDGFFIRPF 967

  Fly   768 YKMMLQKPIDLKDMESVDTEYYNSLMWIKENDPRILELTFCLDEDVFGQKSQHELKPGGANIDVT 832
            |||||||.|.|.||||||:|||:||.||.||||..|:|.|.:||::|||..|||||.||:.|.||
Mouse   968 YKMMLQKLITLHDMESVDSEYYSSLRWILENDPTELDLRFIIDEELFGQTHQHELKTGGSEIVVT 1032

  Fly   833 NENKDEYIKLVIEWRFVARVKEQMSSFLDGFGSIIPLNLIKIFDEHELELLMCGIQNIDVKDWRE 897
            |:||.|||.|||:||||.|:::||::|.:||..:||.:|||||||:||||||||:.::||.||||
Mouse  1033 NKNKKEYIYLVIQWRFVNRIQKQMAAFKEGFFELIPQDLIKIFDENELELLMCGLGDVDVNDWRE 1097

  Fly   898 NTLYKGDYHMNHIIIQWFWRAVLSFSNEMRSRLLQFVTGTSRVPMNGFKELYGSNGPQMFTIEKW 962
            :|.||..|.|||.:|.|||:||....:|.|.|||||||||||||||||.|||||||||.||:|:|
Mouse  1098 HTKYKNGYSMNHQVIHWFWKAVWMMDSEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQSFTVEQW 1162

  Fly   963 GTPNNFPRAHTCFNRLDLPPYEGYLQLKDKLIKAIEGSQGFAGVD 1007
            |||:..||||||||||||||||.:.:|.|||..|||.:|||.|||
Mouse  1163 GTPDKLPRAHTCFNRLDLPPYESFDELWDKLQMAIENTQGFDGVD 1207

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Nedd4NP_648993.1 C2_NEDD4_NEDD4L 71..204 CDD:175999 26/58 (45%)
WW 248..277 CDD:278809 21/28 (75%)
WW 531..560 CDD:278809 12/34 (35%)
WW 581..613 CDD:197736 24/31 (77%)
HECTc 650..1003 CDD:238033 251/352 (71%)
HECTc 674..1003 CDD:214523 238/328 (73%)
Nedd4NP_001344927.1 C2 <477..530 CDD:326325 26/57 (46%)
WW 574..602 CDD:238122 20/27 (74%)
WW 727..756 CDD:306827 3/28 (11%)
WW 781..813 CDD:197736 4/31 (13%)
HECTc 874..1203 CDD:214523 225/336 (67%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 465 1.000 Domainoid score I469
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 880 1.000 Inparanoid score I404
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG49869
OrthoDB 1 1.010 - - D142537at33208
OrthoFinder 1 1.000 - - FOG0000080
OrthoInspector 1 1.000 - - otm43672
orthoMCL 1 0.900 - - OOG6_100256
Panther 1 1.100 - - LDO PTHR11254
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2273
SonicParanoid 1 1.000 - - X1682
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
1514.870

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