DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nedd4 and oxi-1

DIOPT Version :9

Sequence 1:	NP_648993.1	Gene:	Nedd4 / 39958	FlyBaseID:	FBgn0259174	Length:	1007	Species:	Drosophila melanogaster
Sequence 2:	NP_499392.1	Gene:	oxi-1 / 176515	WormBaseID:	WBGene00003898	Length:	1066	Species:	Caenorhabditis elegans

Alignment Length:	407	Identity:	127/407 - (31%)
Similarity:	198/407 - (48%)	Gaps:	36/407 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   629 YKQKYEYFKSHIRKPTNVPN-KFEIRIRRTSILEDSYRIISSVTKTDLLKTKLWVEFEGETGLDY 692
            ::::.:..|:.:....|.|. :..|.::|..|:||.:..:|.:| ...||:.:.|:|..|.|||.
Worm   661 FRRQVQDDKNRVATSLNDPQMQTWITVQRNRIIEDGFNHLSKLT-IPALKSTIRVKFVNEQGLDE 724

  Fly   693 GGL-----AREWFYLLSKEMFNPYYGLFEYSAMDNYTLQINNGSGLCNEEHLSYFKFIGRIAGMA 752
            .|:     .:|:..|..|::|:|...||  |......|..:..|.| :::||:.|.|:||:.|.|
Worm   725 AGIDQDGVFKEFLELTLKKVFDPQLNLF--STTSTGVLYPSPTSSL-HDDHLALFTFVGRMLGKA 786

  Fly   753 VYHGKLLDAFFIRPFYKMML--QKPIDLKDMESVDTEYYNSLMWIK--ENDPRILELTFCLDEDV 813
            ||.|.::|..........:|  .:.....::..:|.|.|.||.::|  |.:...|.|||.:|||.
Worm   787 VYEGIVVDVQLAPVLLAAVLGSHRLCAFDELSQLDPELYRSLTFVKRYEGEMADLSLTFSVDEDF 851

  Fly   814 FGQKSQHELKPGGANIDVTNENKDEYIKLVIEWRFVARVKEQMSSFLDGFGSIIPLNLIKIFDEH 878
            .|:.|..:|.|.|..|.||||||.:|:..:...|...|.:||..:|:.|..||:....:.:|..:
Worm   852 MGKISTVDLVPSGRTISVTNENKIDYVHRMAHHRVFRRTQEQCKAFVTGMQSILQPTWLSLFAPN 916

  Fly   879 ELELLMCGI-QNIDVKDWRENTLYKGDYHMNHIIIQWFWRAVLS-FSNEMRSRLLQFVTGTSRVP 941
            :|:.|:.|: .:||:.|.:.|..|.|.:|.||.:|:|.|..:.: |::|.|...|:|||..||.|
Worm   917 DLQCLISGVNSDIDLADLKRNVQYFGGFHGNHRLIKWLWDILENKFTSEERKLFLKFVTSCSRPP 981

  Fly   942 MNGFKEL--------------------YGSNGPQMFTIEKWGTPNNFPRAHTCFNRLDLPPYEGY 986
            :.||..|                    .||.......:.|.......|.|.||||.|.||.|...
Worm   982 VLGFSYLEPPFSIRCVEVSDDQDQGDTLGSVVRGFLALRKGTAATRLPTASTCFNLLKLPNYNKK 1046

  Fly   987 LQLKDKLIKAIEGSQGF 1003
            ..|.:||..||....||
Worm  1047 SLLLEKLRYAIHAGTGF 1063

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nedd4	NP_648993.1	C2_NEDD4_NEDD4L	71..204	CDD:175999
		WW	248..277	CDD:278809
		WW	531..560	CDD:278809
		WW	581..613	CDD:197736
		HECTc	650..1003	CDD:238033	122/383 (32%)
		HECTc	674..1003	CDD:214523	115/359 (32%)
oxi-1	NP_499392.1	HECTc	684..1064	CDD:238033	124/384 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810