DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nedd4 and etc-1

DIOPT Version :9

Sequence 1:	NP_648993.1	Gene:	Nedd4 / 39958	FlyBaseID:	FBgn0259174	Length:	1007	Species:	Drosophila melanogaster
Sequence 2:	NP_495842.1	Gene:	etc-1 / 174388	WormBaseID:	WBGene00008429	Length:	1001	Species:	Caenorhabditis elegans

Alignment Length:	475	Identity:	120/475 - (25%)
Similarity:	217/475 - (45%)	Gaps:	58/475 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   568 MPNQTRRVEDDLGPLPEGWEERVHTDGRVFYIDHNTRTTQWEDPRLSNPNIAGQA---------- 622
            |||...::|..:.      .|.|.....::.:|.::.... ||...:.|.:..:|
Worm   543 MPNGRLQIERTMD------TEFVERLAAIYEMDSDSENDD-EDEDNNLPAVLRRAICVMKHIPFI 600

  Fly   623 VPYSRDYK--------QKYEYFKSHIRKPTNVPNKFEIRIRRTSILEDSYRIISSVTKTD----- 674
            ||:....|        .|.:::.|......|.|:   :.:||..:..|::...:...:.|
Worm   601 VPFMDRVKLFTRLLNQDKEKHYTSTFGMGFNGPS---VTVRRDQVYMDAFETFAPKMQGDKVNDL 662

  Fly   675 --LLKTKLWVEFEG--ETGLDYGGLAREWFYLLSKEMFNPYYGLFEYSAMDNYTLQIN-NGSGLC 734
              :::.|: |.:.|  |:|:|.||:.||:...|.|..||...|.|.::  ::..|..| ....|.
Worm   663 KSMVRVKM-VNWAGMNESGIDGGGIFREFLSELLKTAFNVERGFFTFT--ESKLLYPNPTAPFLL 724

  Fly   735 NEEHLSYFKFIGRIAGMAVYHGKLLDA----FFIRPFYKMMLQKPIDLKDMESVDTEYYNSLMWI 795
            ..:.|::|:||||:.|..:|..:|.:.    |||...::....|.:||:.|:|.|...:..|..:
Worm   725 GVDCLAHFQFIGRMIGKLIYERQLQEVRFAEFFIAQIFETDKNKDVDLQHMKSFDPIIFKHLKAL 789

  Fly   796 KENDPR---ILELTFCLDEDVFGQKSQHELKPGGANIDVTNENKDEYIKLVIEWRFVARVKEQMS 857
            ::.:.|   .|:|.|.:.....|......|||.|:...||.||..||::|.:.:....|:...:.
Worm   790 QKMNNRELDELQLDFSVVTSDMGLVRNVNLKPNGSKFRVTVENVHEYVRLYVNYHLKQRIASMVD 854

  Fly   858 SFLDGFGSIIPLNLIKIFDEHELELLMCGIQNI----DVKDWRENTLYKGDYHMNHIIIQWFWRA 918
            :...|...||.:..:::|..|||::::.|.:.:    :::.:.|.....|...:|:  .:.||..
Worm   855 AVRKGISEIISIEWMRMFAPHELQIMIAGYEEVFTAKELRKFCELRFAAGTQDINY--EEMFWDV 917

  Fly   919 VLSFSNEMRSRLLQFVTGTSRVPMNGFKELYGSNGPQMFTIEKWGTPNNFPRAHTCFNRLDLPPY 983
            :...||:.:..||:||||.||.|::|||.:.    |:|..:....:.:..|.:.||.|.|.:|.|
Worm   918 IDKLSNDDKKALLKFVTGCSRAPVDGFKSIQ----PRMGVLVIPSSDDELPTSATCMNMLRIPKY 978

  Fly   984 EGYLQLKDKLIKAIEGSQGF 1003
            ....:|::||..||....||
Worm   979 SNRTKLEEKLRYAINSGAGF 998

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nedd4	NP_648993.1	C2_NEDD4_NEDD4L	71..204	CDD:175999
		WW	248..277	CDD:278809
		WW	531..560	CDD:278809
		WW	581..613	CDD:197736	5/31 (16%)
		HECTc	650..1003	CDD:238033	100/373 (27%)
		HECTc	674..1003	CDD:214523	97/349 (28%)
etc-1	NP_495842.1	HECTc	661..998	CDD:214523	96/345 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810