DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Nedd4 and wwp-1

DIOPT Version :9

Sequence 1:NP_648993.1 Gene:Nedd4 / 39958 FlyBaseID:FBgn0259174 Length:1007 Species:Drosophila melanogaster
Sequence 2:NP_740775.1 Gene:wwp-1 / 171647 WormBaseID:WBGene00007009 Length:794 Species:Caenorhabditis elegans


Alignment Length:1011 Identity:329/1011 - (32%)
Similarity:449/1011 - (44%) Gaps:265/1011 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly    37 AASVAGQQQTRQEFGNGYTPRRSLAAVNDSGDSCHLRIVVLTGQSLAKKDIFGASDPYVRIDLNT 101
            |.:....||......|| ||    |..|.|.....:.:.|:.. |..|     |:|.||.|..:|
 Worm     2 ARNEPSSQQPSSSGSNG-TP----AQQNGSAKPSKVTVKVVNA-SFTK-----AADCYVEITSDT 55

  Fly   102 INGDINIDSVLTKTKKKTLNPTWNEEFIFRVKPSEHKLV-FQVFDENRLTRDDFLGMVELTLVNL 165
            .:.    ....|..||||:.|.|||.  ..|..:|...: |::..:.:|..|..|||.:|.|.:|
 Worm    56 SSA----APKKTTVKKKTMAPEWNEH--LNVHANESSTISFRLLQKAKLFDDTCLGMAKLKLSSL 114

  Fly   166 PTEQEGR----------------TIGE-----QSYTLRPRRSVGAKSRIKGTLRIYHAFIRETRE 209
            ...:.|.                .||.     ..|..|.|||.|.::....:          ...
 Worm   115 TRNENGEFKNDINNISLLAKDSSKIGTLNIIFSGYPERKRRSAGVRAETAAS----------ASS 169

  Fly   210 QSEPSSGNSDGEWEHVEATNAGETSAQPHPF-------------PTGGHDALPAGWEERQDANGR 261
            ::..|:|.:........||...:|.|.|...             ..|..:.||.|||.|.|..||
 Worm   170 EASTSNGVATSSSARRPATAKRDTLAAPTSTAAAAAAATAGGTPAAGAEEQLPDGWEMRFDQYGR 234

  Fly   262 TYYVNHTARTTQWDRPTVLNSHSSQSTDD--QLASDFQRRFHISVDDTESGRSADSISHNSIEDN 324
            .|||:||.::|.|:||      |:|....  ::..|.:.|.:.             :.||:    
 Worm   235 KYYVDHTTKSTTWERP------STQPLPQGWEMRRDPRGRVYY-------------VDHNT---- 276

  Fly   325 NNAAGLAYTPKTAATSSAPPNTPTNNNGILAQIAMQYRAEEDQDPTVDHTSFVYNSLRHPVAHRQ 389
                                                 |....|.||.|...          ||.|
 Worm   277 -------------------------------------RTTTWQRPTADMLE----------AHEQ 294

  Fly   390 PEISATSLQNDLRPVREAPGVPDIAITNPFTRRAAGNMAGGAGWQQERRRQQMQLHIQQHQQRQQ 454
                                                       ||..|.:..:            
 Worm   295 -------------------------------------------WQSGRDQAML------------ 304

  Fly   455 QQQQNRILLDVDHRQQEPQHRGQRHQQQHRPSNEDTDHTDSHNPSDISAPSTRRNSEEDNAAVPP 519
             |.:.|.||                 ||:..|.:|                             |
 Worm   305 -QWEQRFLL-----------------QQNNFSADD-----------------------------P 322

  Fly   520 MEQNTGGEEEPLPPRWSMQVAPN-GRTFFIDHASRRTTWIDPRNGRASPMPNQTRRVEDDLGPLP 583
            :        .|||..|..:..|| .|.:|::|.:|.|.|.|||        .|..|..|.  |||
 Worm   323 L--------GPLPEGWEKRQDPNTSRMYFVNHVNRTTQWEDPR--------TQGFRGSDQ--PLP 369

  Fly   584 EGWEERVHTDGRVFYIDHNTRTTQWEDPRLSNP----NIAGQAVPYSRDYKQKYEYFKSHIRKPT 644
            :|||.|....|..|:|||.::||.:.|||...|    .:.|..:...:.::.|...|: ::....
 Worm   370 DGWEMRFTEQGVPFFIDHQSKTTTYNDPRTGKPVGPLGVVGVQMAMEKSFRWKIAQFR-YLCLSN 433

  Fly   645 NVPNKFEIRIRRTSILEDSYRIISSVTKTDLLKTKLWVEFEGETGLDYGGLAREWFYLLSKEMFN 709
            :|||..:|.:.|.::.|||::.|......| |:.:|:::|.||.||||||:|||||:|||.|:.|
 Worm   434 SVPNHVKITVSRNNVFEDSFQEIMRKNAVD-LRRRLYIQFRGEEGLDYGGVAREWFFLLSHEVLN 497

  Fly   710 PYYGLFEYSAMDNYTLQINNGSGLCNEEHLSYFKFIGRIAGMAVYHGKLLDAFFIRPFYKMMLQK 774
            |.|.||.|:..:||:||||..| ..|.:||.||::|||...||::|||.:.:.|..||||.||.|
 Worm   498 PMYCLFMYAGNNNYSLQINPAS-FVNPDHLKYFEYIGRFIAMALFHGKFIYSGFTMPFYKKMLNK 561

  Fly   775 PIDLKDMESVDTEYYNSLMWIKEN--DPRILELTFCLDEDVFGQKSQHELKPGGANIDVTNENKD 837
            .|.|||:|.||:|.||||||||:|  |...:||.|..|.::.|:...:|||.||..|.||.|||.
 Worm   562 KIVLKDIEQVDSEIYNSLMWIKDNNIDECDMELYFVADYELLGELKTYELKEGGTEIAVTEENKL 626

  Fly   838 EYIKLVIEWRFVARVKEQMSSFLDGFGSIIPLNLIKIFDEHELELLMCGIQNIDVKDWRENTLYK 902
            |||:|::||||...|::|..:|..||.|:.||..::.|||.|||||:||:|::||.||:.||:|:
 Worm   627 EYIELLVEWRFNRGVEQQTKAFFTGFNSVFPLEWMQYFDERELELLLCGMQDVDVDDWQRNTVYR 691

  Fly   903 GDYHMNHIIIQWFWRAVLSFSNEMRSRLLQFVTGTSRVPMNGFKELYGSNGPQMFTIEKWGTPNN 967
             .|......:.|||:.|.|...|.|:|||||||||.|||:.||.||.||.|||:|.||:.|..|.
 Worm   692 -HYAPQSKQVTWFWQWVRSLDQEKRARLLQFVTGTCRVPVGGFSELMGSTGPQLFCIERVGKENW 755

  Fly   968 FPRAHTCFNRLDLPPYEGYLQLKDKLIKAIEGSQGF 1003
            .||:||||||||||||..|.||.:||..|||.::||
 Worm   756 LPRSHTCFNRLDLPPYRSYDQLVEKLSMAIEMTEGF 791

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Nedd4NP_648993.1 C2_NEDD4_NEDD4L 71..204 CDD:175999 38/154 (25%)
WW 248..277 CDD:278809 16/28 (57%)
WW 531..560 CDD:278809 11/29 (38%)
WW 581..613 CDD:197736 16/31 (52%)
HECTc 650..1003 CDD:238033 185/354 (52%)
HECTc 674..1003 CDD:214523 179/330 (54%)
wwp-1NP_740775.1 C2 29..147 CDD:301316 32/129 (25%)
WW 221..250 CDD:278809 16/28 (57%)
WW 255..284 CDD:278809 6/82 (7%)
WW 325..357 CDD:197736 13/31 (42%)
WW 367..398 CDD:197736 15/30 (50%)
HECTc 440..792 CDD:238033 187/355 (53%)
HECTc 463..791 CDD:214523 179/330 (54%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000080
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100256
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2273
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
43.840

Return to query results.
Submit another query.