DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nedd4 and PLEKHA7

DIOPT Version :9

Sequence 1:	NP_648993.1	Gene:	Nedd4 / 39958	FlyBaseID:	FBgn0259174	Length:	1007	Species:	Drosophila melanogaster
Sequence 2:	XP_024304124.1	Gene:	PLEKHA7 / 144100	HGNCID:	27049	Length:	1365	Species:	Homo sapiens

Alignment Length:	325	Identity:	72/325 - (22%)
Similarity:	120/325 - (36%)	Gaps:	100/325 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   529 EPLPPRWSMQVAPNGRTFFIDHASRRTTWIDPRNGRASPMPNQTRRVEDDLGPLPEGWEERVHTD 593
            :.||..||..|..:||.|||:...|.|||:.||.|  .|: |....:..|   ||.||||....:
Human     9 DTLPEHWSYGVCRDGRVFFINDQLRCTTWLHPRTG--EPV-NSGHMIRSD---LPRGWEEGFTEE 67

  Fly   594 GRVFYIDHNTRTTQWEDPRLSNPNIAGQAVPYSRDYKQKYEYFKSHIRKPTNVPNKFEIRIRRTS 658
            |..::||||.:||.:..|      :.||..|.:.::..:.|        |....:|.:...|.:|
Human    68 GASYFIDHNQQTTAFRHP------VTGQFSPENSEFILQEE--------PNPHMSKQDRNQRPSS 118

  Fly   659 ILEDSY--------------RIISSVTKTDL---------------LKTKLWVEFEGETGLDYGG 694
            ::.::.              :||.|.:|...               :..:.|:..:..:|:..
Human   119 MVSETSTAGTASTLEAKPGPKIIKSSSKVHSFGKRDQAIRRNPNVPVVVRGWLHKQDSSGMRL-- 181

  Fly   695 LAREWFYLLSKEMFNPYYGLFEYS-----------AMDNYTLQINNGSGLCNEEHLS-YFKFIGR 747
            ..|.||.|..       |.||.|.           .:.:|.:     |.:..|:.:| .:.|...
Human   182 WKRRWFVLAD-------YCLFYYKDSREEAVLGSIPLPSYVI-----SPVAPEDRISRKYSFKAV 234

  Fly   748 IAGM--AVYH----GKLLDAFFIRPFY-------------------KMMLQKPIDLKDMESVDTE 787
            ..||  .:|:    |...:...:|.:|                   ..:|.:....:|||.|:.:
Human   235 HTGMRALIYNSSTAGSQAEQSGMRTYYFSADTQEDMNAWVRAMNQAAQVLSRSSLKRDMEKVERQ 299

Fly 788 787
Human 300 299

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nedd4	NP_648993.1	C2_NEDD4_NEDD4L	71..204	CDD:175999
		WW	248..277	CDD:278809
		WW	531..560	CDD:278809	14/28 (50%)
		WW	581..613	CDD:197736	14/31 (45%)
		HECTc	650..1003	CDD:238033	32/204 (16%)
		HECTc	674..1003	CDD:214523	26/166 (16%)
PLEKHA7	XP_024304124.1	WW	11..40	CDD:306827	14/28 (50%)
		WW	56..85	CDD:306827	13/28 (46%)
		PH_PEPP1_2_3	159..281	CDD:270068	21/135 (16%)
		NESP55	<299..460	CDD:115071	0/1 (0%)
		DUF1640	779..905	CDD:311647
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900