Protein Alignment Nedd4 and Nedd4

DIOPT Version :10

• Sequence 1: NP_648993.1
• Gene: Nedd4 / 39958
• FlyBaseID: FBgn0259174
• Length: 1007
• Species: Drosophila melanogaster
• Sequence 2: XP_061505717.1
• Gene: Nedd4 / 1273805
• VectorBaseID: AGAMI1_001899
• Length: 1056
• Species: Anopheles gambiae
• Alignment Length: 1107
• Identity: 587/1107 - (53%)
• Similarity: 710/1107 - (64%)
• Gaps: 181/1107 - (16%)

  Fly    29 PRPPPRRRAASVAGQQQTRQEFGNGYTPRRSLAAVNDSGDSCHLRIVVLTGQSLAKKDIFGASDP 93
            |:.||||||.||...........:.:|||.||...|:. |.|::||.||....||||||||.|||
Mosquito     3 PQRPPRRRAQSVGNSSYGSSPALSSHTPRGSLFTANEE-DVCYVRIRVLGASGLAKKDIFGYSDP 66

  Fly    94 YVRIDLNTINGDINIDSVLTKTKKKTLNPTWNEEFIFRVKPSEHKLVFQVFDENRLTRDDFLGMV 158
            ||:|:.|||.||:|:|.::||||::||||.|||||:|||||:|||||||||||||||||.|:|:|
Mosquito    67 YVKIEQNTITGDVNVDHMVTKTKRRTLNPVWNEEFVFRVKPNEHKLVFQVFDENRLTRDGFMGLV 131

  Fly   159 ELTLVNLPTEQEGRTIGEQSYTLRPRR--SVGAKSRIKGTLRIYHAFIRETREQSEPSSG---NS 218
            :|||:|||.|.:.|||..|.||||.:|  |:...::::|||.:|||.:|:    .:|:.|   ::
Mosquito   132 DLTLINLPHESDQRTIAPQRYTLRAKRQSSLRVSTKVRGTLELYHAIMRD----DDPAIGRTRSA 192

  Fly   219 DGEWEHVEAT--------NAGETSAQPHPFPTGGH----------------DALPAGWEERQDAN 259
            .|......||        |||....|..|.....|                ||||.|||.|||..
Mosquito   193 IGGSNRASATSTPLAAHRNAGLYPQQQLPLNHPQHPQHRLHQLASLTAQPNDALPPGWEVRQDPV 257

  Fly   260 GRTYYVNHTARTTQWDRPTVLNSHSSQSTDDQLASDFQRRFHISVDDTESGRS-------ADSIS 317
            ||.|||||.||||||:|||:   ..||...:::.:.|||||||| :|.::|.|       ||::|
Mosquito   258 GRMYYVNHIARTTQWERPTI---GPSQPGLNEMVAAFQRRFHIS-NDPDNGGSGSNNTSMADTVS 318

  Fly   318 HNSIEDNNNAAGLAYTPKTAATSSAPPNTPTNNNGILAQIAMQYRAEEDQDPTVDHTSFVYNSLR 382
            ..|  :|.:....|...::.|.....|.....::.:|:.:..|         :.|..:||....|
Mosquito   319 ITS--ENGDTTAAAVGNRSGAPGIGSPMVLAADHPLLSTLMAQ---------SGDGGAFVATPER 372

  Fly   383 ----------HPVAHRQPEISATSLQN------DLRPVREAPGVPDIAITNPFTRRAAGNMAGGA 431
                      .|.....|..|..|:.:      .:||:|.||..|.               .||.
Mosquito   373 PASAPRGDDAEPTVGLSPSPSVASIASSGAGGTSIRPIRPAPPPPP---------------GGGG 422

  Fly   432 GWQQERRRQQMQLHIQQHQQRQQQQQQNRILLDVDHRQQEPQHRGQRHQQQ----HRPSNEDTDH 492
            |.......:...:......||               |:..|   |.....|    ...|.|..|.
Mosquito   423 GGSSASSARASPVGTPVPSQR---------------RRSSP---GSSESAQATAIEASSGEAGDT 469

  Fly   493 T----------DSHNP---------SDISAPST--RRNSE--------EDNAAVPPMEQNTGGEE 528
            |          |...|         ::..||||  |..||        |..||..|...:|....
Mosquito   470 TPGPSAPIATADDEQPNASAPVNGSAEGGAPSTVPREVSETATSSIGSEQTAATTPNRPDTAVAV 534

  Fly   529 EP-------------------LPPRWSMQVAPNGRTFFIDHASRRTTWIDPRNGRASPMPN---- 570
            :|                   |||.|::|||.|||.|||||.::.|:|:|||.|.||.:|:
Mosquito   535 QPTSPSHPTTPAPAAQPNATGLPPGWAVQVASNGRLFFIDHINKTTSWVDPRTGLASTIPSAAGS 599

  Fly   571 --------------------QTRRVEDDLGPLPEGWEERVHTDGRVFYIDHNTRTTQWEDPRLSN 615
                                .:|..:|:|||||||||||||:|||.|:||||||||||:||||||
Mosquito   600 DGVAGGGAGSTAGSGHGSRGDSRSSDDNLGPLPEGWEERVHSDGRTFFIDHNTRTTQWDDPRLSN 664

  Fly   616 PNIAGQAVPYSRDYKQKYEYFKSHIRKPTNVPNKFEIRIRRTSILEDSYRIISSVTKTDLLKTKL 680
            |.|||||||||||||||||||||.::||:|||||.:|::||.||||||||:|:|||:.|||||||
Mosquito   665 PKIAGQAVPYSRDYKQKYEYFKSQLQKPSNVPNKIDIKVRRASILEDSYRVINSVTRLDLLKTKL 729

  Fly   681 WVEFEGETGLDYGGLAREWFYLLSKEMFNPYYGLFEYSAMDNYTLQINNGSGLCNEEHLSYFKFI 745
            ||||||||||||||||||||||||||||||||||||||||||||||||..|||||||||:||:||
Mosquito   730 WVEFEGETGLDYGGLAREWFYLLSKEMFNPYYGLFEYSAMDNYTLQINPNSGLCNEEHLNYFRFI 794

  Fly   746 GRIAGMAVYHGKLLDAFFIRPFYKMMLQKPIDLKDMESVDTEYYNSLMWIKENDPRILELTFCLD 810
            |||||||:|||||||||||||||||||||.|||||||:|||||||||::||||||..|.|||.:|
Mosquito   795 GRIAGMAIYHGKLLDAFFIRPFYKMMLQKSIDLKDMEAVDTEYYNSLLYIKENDPSTLMLTFSVD 859

  Fly   811 EDVFGQKSQHELKPGGANIDVTNENKDEYIKLVIEWRFVARVKEQMSSFLDGFGSIIPLNLIKIF 875
            |:.||..:|.||||.||:::|:||||||||:|||:|||.||||:||.:||:|..|::||:|:|||
Mosquito   860 EESFGTTNQRELKPNGADLEVSNENKDEYIRLVIDWRFEARVKDQMQAFLEGVSSLVPLHLLKIF 924

  Fly   876 DEHELELLMCGIQNIDVKDWRENTLYKGDYHMNHIIIQWFWRAVLSFSNEMRSRLLQFVTGTSRV 940
            ||:||||||||||:|||.||::||:|||||:.||.::||||||||||:|||||||||||||||||
Mosquito   925 DENELELLMCGIQSIDVNDWKKNTMYKGDYYANHAVVQWFWRAVLSFNNEMRSRLLQFVTGTSRV 989

  Fly   941 PMNGFKELYGSNGPQMFTIEKWGTPNNFPRAHTCFNRLDLPPYEGYLQLKDKLIKAIEGSQGFAG 1005
            |||||||||||||||:||||||||.|||||||||||||||||||.|.|||:|||.||||||||||
Mosquito   990 PMNGFKELYGSNGPQLFTIEKWGTVNNFPRAHTCFNRLDLPPYESYAQLKEKLISAIEGSQGFAG 1054

  Fly  1006 VD 1007
            ||
Mosquito  1055 VD 1056

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nedd4	NP_648993.1	C2_NEDD4_NEDD4L	71..204	CDD:175999	86/134 (64%)
		WW	248..277	CDD:459800	21/28 (75%)
		HUL4	<523..1003	CDD:227354	377/522 (72%)
Nedd4	XP_061505717.1	None