DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nedd4 and Magi2

DIOPT Version :9

Sequence 1:	NP_648993.1	Gene:	Nedd4 / 39958	FlyBaseID:	FBgn0259174	Length:	1007	Species:	Drosophila melanogaster
Sequence 2:	NP_446073.2	Gene:	Magi2 / 113970	RGDID:	621855	Length:	1277	Species:	Rattus norvegicus

Alignment Length:	239	Identity:	56/239 - (23%)
Similarity:	97/239 - (40%)	Gaps:	53/239 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   455 QQQQNRILLDVDHRQQEPQHRGQRHQQQHRP---------SNEDTDHTD------SHNPSD---- 500
            ::::|:.:.:::....||    ...:::.||         :.|.::|.|      ...||.
  Rat   214 KRKRNKSVTNMEKASIEP----PEEEEEERPVVNGNGVVITPESSEHEDKSAGASGETPSQPYPA 274

  Fly   501 --ISAPSTRRNSEEDNAAVPPMEQNTGGEEEPLPPRWSMQVAPNGRTFFIDHASRRTTWIDPRNG 563
              .|.|...::..:|..:..|.|..   :.:|||..|.|.....|..:||||.::.|:|:|||..
  Rat   275 PVYSQPEELKDQMDDTKSTKPEENE---DSDPLPDNWEMAYTEKGEVYFIDHNTKTTSWLDPRLA 336

  Fly   564 RASPMPNQTRRVEDDLGPLPEGWEERVHTDGRVFYIDHNTRTTQWEDPRL---------SNPNIA 619
            :.:....:.:..|     ||.|||:........:|:||..|.||:|:|.|         :.|:..
  Rat   337 KKAKPAEECKENE-----LPYGWEKIDDPIYGTYYVDHINRRTQFENPVLEAKRKLQQHNMPHTE 396

  Fly   620 GQAVP-----------YSRDYKQKYEYFKSHIRKPTNVPNKFEI 652
            ....|           ::||..|....|.|...|.:|:...|.|
  Rat   397 LGTKPLQAPGFREKPLFTRDASQLKGTFLSTTLKKSNMGFGFTI 440

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nedd4	NP_648993.1	C2_NEDD4_NEDD4L	71..204	CDD:175999
		WW	248..277	CDD:278809
		WW	531..560	CDD:278809	11/28 (39%)
		WW	581..613	CDD:197736	13/31 (42%)
		HECTc	650..1003	CDD:238033	2/3 (67%)
		HECTc	674..1003	CDD:214523
Magi2	NP_446073.2	PDZ_signaling	22..96	CDD:238492
		GuKc	118..291	CDD:214504	13/80 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	205..308		18/100 (18%)
		Interaction with DDN. /evidence=ECO:0000250	302..381		29/83 (35%)
		WW	304..333	CDD:395320	11/28 (39%)
		WW	350..381	CDD:197736	13/30 (43%)
		PDZ	428..509	CDD:214570	4/13 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	556..575
		PDZ	602..683	CDD:214570
		MAGI_u5	687..758	CDD:406953
		PDZ	775..861	CDD:214570
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	869..913
		PDZ_signaling	920..1007	CDD:238492
		PRK10263	<1007..>1135	CDD:236669
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1011..1130
		PDZ_signaling	1140..1220	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900