DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Nedd4 and WWP1

DIOPT Version :9

Sequence 1:NP_648993.1 Gene:Nedd4 / 39958 FlyBaseID:FBgn0259174 Length:1007 Species:Drosophila melanogaster
Sequence 2:NP_008944.1 Gene:WWP1 / 11059 HGNCID:17004 Length:922 Species:Homo sapiens


Alignment Length:1116 Identity:342/1116 - (30%)
Similarity:484/1116 - (43%) Gaps:373/1116 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly    58 RSLAAVNDSGDSCHLRIVVLTGQSLAKKDIFGASDPYVRIDLNTINGDINIDSVLTKTKK--KTL 120
            ||..:.|.|| ...|::.|.:.:...||:.||.:          |..::.:|..:|||.|  .:.
Human     7 RSDTSNNHSG-RLQLQVTVSSAKLKRKKNWFGTA----------IYTEVVVDGEITKTAKSSSSS 60

  Fly   121 NPTWNEEFIFRVKPSEHKLVFQVFDENRLTRDDFLGMV--------------------------- 158
            ||.|:|:....|.| :..|.|||:....|..|..||..                           
Human    61 NPKWDEQLTVNVTP-QTTLEFQVWSHRTLKADALLGKATIDLKQALLIHNRKLERVKEQLKLSLE 124

  Fly   159 ---------ELTLV--NLPTEQEGRTIGEQSYTL-------------RPRRSVGAKSRIKGTLRI 199
                     |||:|  .|..|||..|....|.|:             .|.....|:..::||..|
Human   125 NKNGIAQTGELTVVLDGLVIEQENITNCSSSPTIEIQENGDALHENGEPSARTTARLAVEGTNGI 189

  Fly   200 YHAFIRETREQ----------------------------------SEPSSGNSDGE--------- 221
            .:.....|..|                                  |||:....:||         
Human   190 DNHVPTSTLVQNSCCSYVVNGDNTPSSPSQVAARPKNTPAPKPLASEPADDTVNGESSSFAPTDN 254

  Fly   222 ----------WEHVEATNAGETSAQPHPF------------------------------------ 240
                      .|:..:.|...|:.:..|.                                    
Human   255 ASVTGTPVVSEENALSPNCTSTTVEDPPVQEILTSSENNECIPSTSAELESEARSILEPDTSNSR 319

  Fly   241 ------------PTGGHD------------ALPAGWEERQDANGRTYYVNHTARTTQWDRPTVLN 281
                        |.|..|            .||:|||:|:|.:||||||:|..|||.|:||    
Human   320 SSSAFEAAKSRQPDGCMDPVRQQSGNANTETLPSGWEQRKDPHGRTYYVDHNTRTTTWERP---- 380

  Fly   282 SHSSQSTDDQLASDFQRRFHISVDDTESGRSADSISHNSIEDNNNAAGLAYTPKTAATSSAPPNT 346
                    ..|...::||    |||.   |....:.||:                          
Human   381 --------QPLPPGWERR----VDDR---RRVYYVDHNT-------------------------- 404

  Fly   347 PTNNNGILAQIAMQYRAEEDQDPTVDHTSFVYNSLRHPVAHRQPEISATSLQNDLRPVREAPGVP 411
                           |....|.||::                       |::|            
Human   405 ---------------RTTTWQRPTME-----------------------SVRN------------ 419

  Fly   412 DIAITNPFTRRAAGNMAGGAGWQQERRRQQMQLHIQQHQQRQQQQQQNRILLDVDHRQQEPQHRG 476
                   |.:           ||.:  |.|:|..:||..||...                     
Human   420 -------FEQ-----------WQSQ--RNQLQGAMQQFNQRYLY--------------------- 443

  Fly   477 QRHQQQHRPSNEDTDHTDSHNPSDISAPSTRRNSEEDNAAVPPMEQNTGGEEEPLPPRWSMQVAP 541
                                                 :|::...|.:..|   ||||.|..:|..
Human   444 -------------------------------------SASMLAAENDPYG---PLPPGWEKRVDS 468

  Fly   542 NGRTFFIDHASRRTTWIDPRNGRASPMPNQTRRVEDDLGPLPEGWEERVHTDGRVFYIDHNTRTT 606
            ..|.:|::|.::.|.|.|||          |:.:::: .|||||||.|...:|..:::|||||||
Human   469 TDRVYFVNHNTKTTQWEDPR----------TQGLQNE-EPLPEGWEIRYTREGVRYFVDHNTRTT 522

  Fly   607 QWEDPRLSNPNI--AGQAVPYSRDYKQKYEYFKSHIRKPTNVPNKFEIRIRRTSILEDSYRIISS 669
            .::|||....::  .|..:.|.|.::.|..:|: ::.:...:|:..:|.:.|.::.|||::.|.:
Human   523 TFKDPRNGKSSVTKGGPQIAYERGFRWKLAHFR-YLCQSNALPSHVKINVSRQTLFEDSFQQIMA 586

  Fly   670 VTKTDLLKTKLWVEFEGETGLDYGGLAREWFYLLSKEMFNPYYGLFEYSAMDNYTLQINNGSGLC 734
            :...| |:.:|:|.|.||.||||||||||||:|||.|:.||.|.||||:..:||.||||..|.: 
Human   587 LKPYD-LRRRLYVIFRGEEGLDYGGLAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASTI- 649

  Fly   735 NEEHLSYFKFIGRIAGMAVYHGKLLDAFFIRPFYKMMLQKPIDLKDMESVDTEYYNSLMWIKEND 799
            |.:|||||.||||...||::|||.:|..|..||||.||.|.:.:||:||:|||:||||:||::|:
Human   650 NPDHLSYFCFIGRFIAMALFHGKFIDTGFSLPFYKRMLSKKLTIKDLESIDTEFYNSLIWIRDNN 714

  Fly   800 PRI--LELTFCLDEDVFGQKSQHELKPGGANIDVTNENKDEYIKLVIEWRFVARVKEQMSSFLDG 862
            ...  ||:.|.:|.::.|:.:.|:||.||:||.||.|||||||.|:.||||...|:||..:||||
Human   715 IEECGLEMYFSVDMEILGKVTSHDLKLGGSNILVTEENKDEYIGLMTEWRFSRGVQEQTKAFLDG 779

  Fly   863 FGSIIPLNLIKIFDEHELELLMCGIQNIDVKDWRENTLYKGDYHMNHIIIQWFWRAVLSFSNEMR 927
            |..::||..::.|||.|||:::||:|.:|:.||:.||:|: .|..|...|.|||:.|....||:|
Human   780 FNEVVPLQWLQYFDEKELEVMLCGMQEVDLADWQRNTVYR-HYTRNSKQIIWFWQFVKETDNEVR 843

  Fly   928 SRLLQFVTGTSRVPMNGFKELYGSNGPQMFTIEKWGTPNNFPRAHTCFNRLDLPPYEGYLQLKDK 992
            .|||||||||.|:|:.||.||.||||||.|.|||.|.....||:||||||||||||:.|.|||:|
Human   844 MRLLQFVTGTCRLPLGGFAELMGSNGPQKFCIEKVGKDTWLPRSHTCFNRLDLPPYKSYEQLKEK 908

  Fly   993 LIKAIEGSQGF 1003
            |:.|||.::||
Human   909 LLFAIEETEGF 919

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Nedd4NP_648993.1 C2_NEDD4_NEDD4L 71..204 CDD:175999 42/185 (23%)
WW 248..277 CDD:278809 18/28 (64%)
WW 531..560 CDD:278809 10/28 (36%)
WW 581..613 CDD:197736 18/31 (58%)
HECTc 650..1003 CDD:238033 191/354 (54%)
HECTc 674..1003 CDD:214523 185/330 (56%)
WWP1NP_008944.1 C2_E3_ubiquitin_ligase 17..140 CDD:175988 30/133 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 210..388 33/189 (17%)
HUL4 <307..922 CDD:227354 284/804 (35%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 57 1.000 Domainoid score I10869
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000080
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100256
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
54.710

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