DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nedd4 and Plekha5

DIOPT Version :9

Sequence 1:	NP_648993.1	Gene:	Nedd4 / 39958	FlyBaseID:	FBgn0259174	Length:	1007	Species:	Drosophila melanogaster
Sequence 2:	XP_006506926.1	Gene:	Plekha5 / 109135	MGIID:	1923802	Length:	1270	Species:	Mus musculus

Alignment Length:	634	Identity:	124/634 - (19%)
Similarity:	203/634 - (32%)	Gaps:	243/634 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   531 LPPRWSMQVAPNGRTFFIDHASRRTTWIDPRNGRASPMPNQTRRVEDDLGPLPEGWEERVHTDGR 595
            ||..|:..:...||.|||:..::.|||:.|..|.|  :....||...|   ||.||||....:|.
Mouse    13 LPRSWTYGITRGGRVFFINEEAKSTTWLHPVTGEA--VVTGHRRQSTD---LPTGWEEAYTFEGA 72

  Fly   596 VFYIDHNTRTTQWEDP------------------------------------RLSNPNIAGQAVP 624
            .:||:||.|....:.|                                    ..||.|:|.....
Mouse    73 RYYINHNERKVTCKHPVTGQPSQDNCIFVVNDQTVATMTSEDKKERPISMINEASNYNMASDYAV 137

  Fly   625 Y--------SRDYKQKYEYFK--SHIRKPTNVPNKFEIRIRRTSILEDSYRIISSVTKTDLLKTK 679
            :        ||..|:.:.:.|  :.|::..|.|     .:||           ..:.|.|....|
Mouse   138 HPMSPVGRTSRASKKVHNFGKRSNSIKRNPNAP-----VVRR-----------GWLYKQDSTGMK 186

  Fly   680 LWVEFEGETGLDYGGLAREWFYLLSKEMFNPYY------GLFEYSAMDNYTLQINNGSGLCNEEH 738
            ||              .:.||.|....:|  ||      |:.....:.::.:.:     |..|:|
Mouse   187 LW--------------KKRWFVLSDLCLF--YYRDEKEEGILGSILLPSFQIAM-----LTAEDH 230

  Fly   739 LS-YFKFIGRIAGMAVYH-----GK--------LLDAFFIR--PFYKMMLQKPIDLKDMESVDTE 787
            :: .:.|......|..|:     ||        :|||..::  |..::.....:|....:|..|:
Mouse   231 INRKYAFKAAHPNMRTYYFCTDTGKEMELWMKAMLDAALVQTEPVKRITFNFRVDKITTDSASTK 295

  Fly   788 YYNSLMWIKENDPRILELTFCLDEDVFGQKSQHELKPGGANIDVTNENKDEYIKLVIEWRFVARV 852
            ..|::     .:.|:|                  ::|     :|.|..|::.|..:.|.|  |..
Mouse   296 ETNNI-----PNHRVL------------------IRP-----EVQNHQKNKEISKIEEKR--ALE 330

  Fly   853 KEQMSSFLDG----FGSIIPLNLIKIFDEHELELLMCGIQNIDVKDWRENTL-----------YK 902
            .|:.....||    ...|..:.|..:..|:| ....|..||:..:....|:.           .:
Mouse   331 AERYGFQKDGQDRPLTKINSVKLNSLLSEYE-SGPDCPPQNVHYRPINVNSSDGKAVNVSLADVR 394

  Fly   903 GDYHMN------------------HIIIQWFW-----------RAVLSFS---NEMRSRLLQFVT 935
            |..|.|                  ..:.||..           |.|:|:.   ..|.|...|.:
Mouse   395 GGSHPNAGPLATEADRVIQRTNSMQQLEQWIKVQKGRGLEEEPRGVISYQTLPRNMPSHRAQIL- 458

  Fly   936 GTSRVPMNGFKEL------------------YGSNGP------------QMFTIEKW------GT 964
              :|.| .|::.|                  :...||            .|:.:.:|      ..
Mouse   459 --ARCP-EGYRTLPRNSKTRPESICSVTSSGHEKTGPGAEEKRRSMRDDTMWQLYEWQQRQFYHK 520

  Fly   965 PNNFPRAHTCFNRLDLPPYEGYLQLKDKLIKAIEGS---------QGFA 1004
            .:..|| |.|   |..|  :..:|:.|:.:.:|..|         |||:
Mouse   521 QSTLPR-HGC---LSSP--KAMVQVSDQTMHSIPTSPSHGSAAAYQGFS 563

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nedd4	NP_648993.1	C2_NEDD4_NEDD4L	71..204	CDD:175999
		WW	248..277	CDD:278809
		WW	531..560	CDD:278809	11/28 (39%)
		WW	581..613	CDD:197736	13/67 (19%)
		HECTc	650..1003	CDD:238033	81/466 (17%)
		HECTc	674..1003	CDD:214523	78/442 (18%)
Plekha5	XP_006506926.1	WW	13..42	CDD:366073	11/28 (39%)
		WW	59..88	CDD:366073	12/28 (43%)
		PH_PEPP1_2_3	165..268	CDD:270068	26/139 (19%)
		Smc	<623..>864	CDD:224117
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900