DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nedd4 and hectd4

DIOPT Version :9

Sequence 1:	NP_648993.1	Gene:	Nedd4 / 39958	FlyBaseID:	FBgn0259174	Length:	1007	Species:	Drosophila melanogaster
Sequence 2:	XP_009301943.1	Gene:	hectd4 / 101885095	-ID:	-	Length:	4419	Species:	Danio rerio

Alignment Length:	1237	Identity:	246/1237 - (19%)
Similarity:	417/1237 - (33%)	Gaps:	399/1237 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 SSSSSVAGGDVPRPP-----------PRRRAA-----SVAGQQQTRQE----------------F 50
            |||||.:.|..|:.|           .|.|||     :|:|:..:|..                |
Zfish  3316 SSSSSSSPGQTPQSPSLLSKRKKVKLKRERAAVGSASAVSGKSGSRSSECDNALLNMKPEDMLWF 3380

  Fly    51 GNGYT-----------PRRSLAAVNDS---------GDSCHLRIVVLTG---------------- 79
            ..|.|           ..:.|....|:         |.:.|.|::||:|
Zfish  3381 HRGLTLLLILRHLTNKDPQGLGVTGDAVADACQALVGSTAHSRLLVLSGIPTHLEESVVRNAIRR 3445

  Fly    80 -----QSLAKKDIF---GASDP--------YVRIDL---------NTINGDINIDSVLTKTKKKT 119
                 ..|.:.:||   ...||        .|..|:         |:.:..:::.|.|....:.:
Zfish  3446 ACNAHGGLFRDEIFIPVQEEDPKKAKAETTCVPQDVKRECTAGSPNSNSAAMSVSSALQAAFRAS 3510

  Fly   120 LNPTWNEEFIFRVKPSEHKLVFQVFDENRLTRDDFLGMVELTLVNLPTEQEGR--TIGEQS---- 178
            ..|..|:|.:  ..||:.:   ...|...::..:.|   :::|.:  ||.:|.  ::|||.
Zfish  3511 GEPLSNQEMV--NSPSQQQ---APLDPLTVSSQESL---DVSLCS--TESQGSLGSLGEQDSAAT 3565

  Fly   179 --------YTL-RPRRSVGAKSRIKGTLRI---YHAFIRETREQSEPSS-----GNSDGEWEHVE 226
                    ||: .|.........|||...|   ..|.:.:.|.....||     .|.:.|.|.:|
Zfish  3566 SVSDGSSMYTVASPDVHASVTRPIKGYAVIEVRARAQVEKIRASLFNSSDLIGLSNLEREEELME 3630

  Fly   227 ATN---AGETSAQPHPFPTGGHDALPAGWEERQDANGRTYYVNHTARTTQWDRPTVLNSHSSQST 288
            .||   ...:|.....|.|.|..||    ||        |:::.:.|
Zfish  3631 MTNEEILTASSVNQSLFDTQGSSAL----EE--------YFLDKSIR------------------ 3665

  Fly   289 DDQL---ASDFQRRFHISVDDTESGRSADSISHNSIEDNNNAAGLAYTPKTAATSSAPPN----- 345
            .|:|   |.|.......|....|...|...:....:.|       .|..|....|.:|.|
Zfish  3666 GDKLVPGARDVLTDIFKSCIYAEQALSPVPVKPVKVSD-------IYLSKEQINSQSPGNLLHVF 3723

  Fly   346 ----TPTNN--NGILAQIAMQY-----------RAEEDQDPTVDHTSFVYNSLRHPVAHRQPEIS 393
                .|...  :..|.||..:|           :|.::|     |...|. |.:.|:.  :|...
Zfish  3724 FTHVRPPKKVLDDQLTQILRKYGTVKPNKNKHSKAGKEQ-----HQGKVV-STKRPIT--KPPAK 3780

  Fly   394 ATSLQNDLRPV---------------------------REAPGVPDIAITNPFTRRAAGNMAGGA 431
            ..|:.|.:|.|                           .:.|.||:....         .:.|..
Zfish  3781 EKSMLNSVRTVLSEKKTVLKPKSPEKTKPDEKDPEKSPAKKPEVPEEKFL---------TLEGFH 3836

  Fly   432 GWQQERRRQQMQ------------LHIQQ---HQQRQQQQQQNRILLDVDHRQQEPQHRGQRHQQ 481
            .:..:|.:|.::            ||..:   ...|..|:...:...::|....:..:|..||.
Zfish  3837 KFTLDRAKQDIRSVWRAILACGYDLHFDRCTCIDSRHAQKASRKWSFEMDFALVQFVNRLCRHL- 3900

  Fly   482 QHRPSNEDTDHTDSHNPSDISAPSTRRNSEEDNAAVPPMEQNTGGEEEPLPPRWSMQVAPNG--R 544
                         :..|:.:.......::.:|.|. |.:....|...|.|..|:::..:.|.  .
Zfish  3901 -------------AITPARLHPHEVYLDASKDGAD-PEVACLLGVPVESLRLRFALLQSLNSTLE 3951

  Fly   545 TFFIDHASRRTTWIDPRNGRASPMPNQTRRVEDDLGPLPEGWEERVHTDGRVFYIDHNTRTTQWE 609
            :||:.....|.|              ||  .::.:..|      .....|.:||   :|:.|...
Zfish  3952 SFFLPLVELRLT--------------QT--YQNSIATL------LCEAKGLIFY---DTKVTVMN 3991

  Fly   610 DPRLSNPNI---AGQAVP-YSRDYKQ---------KYEYFKSHIRKPTNVPNKFEIRIRRTSILE 661
              |:.|..:   |..|.| .:.|..:         :..||....|:.:.||:. ::.:|..|..:
Zfish  3992 --RVLNATVQRTADHAAPEITLDPLEIVGGEMRAAENTYFCQAARQLSCVPSS-QLCVRIASGGD 4053

  Fly   662 DSYRIISSVTKTDLLKTKLWVEFEGETGLDYGGLAREWFYLLSKEMFNPYYGLFEYSAMD----- 721
            .:|...              :.|.||......|..|.:.:.:.||:        :.||:.
Zfish  4054 PTYAFN--------------IRFTGEEVHGTSGSFRHFLWQVCKEL--------QSSALSLLLPC 4096

  Fly   722 -NYTLQINNGSGLCNEEHLSY-----FKFIGRIAGMAVYHGKLLDAFFIRPFYKMMLQKPIDLK- 779
             :.....|.|..:.....::|     ..|.|::.|:|:.....|....:..|:|.::.:.:|.:
Zfish  4097 PSAAANRNKGKYILTPCPITYAEEQLLNFFGQLLGIAIRADVPLPLDLLGSFWKGLVGEALDPEA 4161

  Fly   780 DMESVDTEYYNSLMWIKE----NDPRILELTFCLD---EDVFGQK------------------SQ 819
            |:...|...|:   :||:    .|...|| ..|.:   :...|:.                  .:
Zfish  4162 DLREADLLTYS---YIKKFESLCDEAELE-ALCAEVSSQSPLGESPDSPSRPCCTFTYITMTGEE 4222

  Fly   820 HELKPGGANIDVTNENKDEYIKLVIEWRF--VARVKEQMSSFLDGFGSIIPLNLIKIFDEHELEL 882
            .||..||.:|.|:.||||.|::.|.|.|.  :..| |.||:...|.||||||.|:.:....|:||
Zfish  4223 VELCQGGRDIAVSWENKDVYVRAVRELRLRELQNV-ECMSAVRAGLGSIIPLQLLTLLSPAEVEL 4286

  Fly   883 LMCGIQNIDVKDWRENTLY-----KGDYHMNHIIIQWFWRAVLSFSNEMRSRLLQFVTGTSRVPM 942
            ..||:.:|:::..:.:|:|     :.|.|     |::||.|:..|:.|..|:.::|.....|:|
Zfish  4287 RTCGLPDINLEFLKAHTMYQVGLMETDQH-----IEFFWAALEMFTQEELSKFIKFACNQERIP- 4345

  Fly   943 NGFKELYGSNGPQMFTIEKW-----------GTPN-NFPRAHTCFNRLDLPPYEGYLQLKDKLIK 995
              |.......||....:..:           |:|: .:.|..||...:.||.|.....:.:||..
Zfish  4346 --FTCPCKDGGPDTAHVPPYPMKIAPPDGTVGSPDQRYIRVETCMFMVKLPQYSSLDVMLEKLRY 4408

  Fly   996 AI 997
            ||
Zfish  4409 AI 4410

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nedd4	NP_648993.1	C2_NEDD4_NEDD4L	71..204	CDD:175999	37/191 (19%)
		WW	248..277	CDD:278809	5/28 (18%)
		WW	531..560	CDD:278809	7/30 (23%)
		WW	581..613	CDD:197736	6/31 (19%)
		HECTc	650..1003	CDD:238033	94/404 (23%)
		HECTc	674..1003	CDD:214523	91/380 (24%)
hectd4	XP_009301943.1	SPRY_HECT_like	2413..2568	CDD:293970
		HECTc	4026..4414	CDD:294058	99/421 (24%)
		HECTc	4060..4410	CDD:214523	89/370 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910