DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Nedd4 and Ube3c

DIOPT Version :9

Sequence 1:NP_648993.1 Gene:Nedd4 / 39958 FlyBaseID:FBgn0259174 Length:1007 Species:Drosophila melanogaster
Sequence 2:NP_598668.1 Gene:Ube3c / 100763 MGIID:2140998 Length:1083 Species:Mus musculus


Alignment Length:485 Identity:144/485 - (29%)
Similarity:220/485 - (45%) Gaps:87/485 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly   554 RTTWIDPRNGRASPMPNQTRRVEDDLGPLPEG------------------WEERVHTDGRVFYID 600
            |..|...|.||..|:.:   .:|..|..||..                  :||||....|:.|.|
Mouse   648 RHVWRFRRMGRIGPLQS---TLEVGLESLPLSVSEERQLAILTELPFVVPFEERVKIFQRLIYAD 709

  Fly   601 HNTRTTQWEDPRLSNPNIAGQAVPYSRDYKQKYEYFKSHIRKPTNVPNKFEIRIRRTSILEDSYR 665
              .:..|.:.|.|...|:.                                  |||..|.||:|.
Mouse   710 --KQEVQGDGPFLDGINVT----------------------------------IRRNYIYEDAYD 738

  Fly   666 IISSVTKTDLLKTKLWVEFEG-----ETGLDYGGLAREWFYLLSKEMFNPYYGLFEYSAMDNYTL 725
            .:|...:.| ||.::.|....     |.|:|.||:.||:...|.|..|||..|.|:.:   |..|
Mouse   739 KLSPENEPD-LKKRIRVHLLNAHGLDEAGIDGGGIFREFLNELLKSGFNPNQGFFKTT---NEGL 799

  Fly   726 QINNGSG--LCNEEHLSYFKFIGRIAGMAVYHGKLLDAFFIRPFYKMMLQK------PIDLKDME 782
            ...|.:.  |..:....::.|:||:.|.|:|...|::.    ||....|.|      .:|:..:.
Mouse   800 LYPNPAAQMLVGDSFARHYYFLGRMLGKALYENMLVEL----PFAGFFLSKLLGTSADVDIHHLA 860

  Fly   783 SVDTEYYNSLMWIK--ENDPRILELTFCLDEDVFGQKSQHELKPGGANIDVTNENKDEYIKLVIE 845
            |:|.|.|.:|:::|  |.|...|.|.|.:..:..|:....|||.||.:|.||..|:..||.||.:
Mouse   861 SLDPEVYRNLLFLKSYEEDVEELGLNFTVVNNDLGEAQVVELKFGGKDIPVTGANRIAYIHLVAD 925

  Fly   846 WRFVARVKEQMSSFLDGFGSIIPLNLIKIFDEHELELLMCGIQ-NIDVKDWRENTLYKGDYHMNH 909
            :|...:::....:|..|..:::.|..:::||:.|:::|:.|.| .:.::|.:..|.|.|.|..:|
Mouse   926 YRLNKQIRPHCLAFRQGLANVVSLEWLRMFDQQEIQVLISGAQVPVSLEDLKSFTNYSGGYSADH 990

  Fly   910 IIIQWFWRAVLSFSNEMRSRLLQFVTGTSRVPMNGFKELYGSNGPQMFTIEKWGTP-NNFPRAHT 973
            .:|:.|||.|..|::|.:.:||:|||..||.|:.||||||.:     |.|...|:. ...|.|.|
Mouse   991 PVIKIFWRVVEGFTDEEKRKLLKFVTSCSRPPLLGFKELYPA-----FCIHNGGSDLERLPTAST 1050

  Fly   974 CFNRLDLPPYEGYLQLKDKLIKAIEGSQGF 1003
            |.|.|.||.:.....|:.||:.|||.:.||
Mouse  1051 CMNLLKLPEFYDEALLRSKLLYAIECAAGF 1080

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Nedd4NP_648993.1 C2_NEDD4_NEDD4L 71..204 CDD:175999
WW 248..277 CDD:278809
WW 531..560 CDD:278809 2/5 (40%)
WW 581..613 CDD:197736 11/49 (22%)
HECTc 650..1003 CDD:238033 121/369 (33%)
HECTc 674..1003 CDD:214523 113/345 (33%)
Ube3cNP_598668.1 Cis-determinant of acceptor ubiquitin-binding. /evidence=ECO:0000250 1..60
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..40
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 354..386
HECTc 723..1081 CDD:238033 124/405 (31%)
HECTc 747..1080 CDD:214523 113/345 (33%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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