Protein Alignment Nedd4 and HUWE1

DIOPT Version :9

• Sequence 1: NP_648993.1
• Gene: Nedd4 / 39958
• FlyBaseID: FBgn0259174
• Length: 1007
• Species: Drosophila melanogaster
• Sequence 2: XP_016884680.1
• Gene: HUWE1 / 10075
• HGNCID: 30892
• Length: 4501
• Species: Homo sapiens
• Alignment Length: 999
• Identity: 297/999 - (29%)
• Similarity: 424/999 - (42%)
• Gaps: 211/999 - (21%)

  Fly   166 PTEQEGRTIGEQSYTL-RP--RRSVGAKSRIKGTLRIYHAFIRETREQSEPSSGNSDGEWEHVEA 227
            |...|...:|:....| .|  |||.....::...|.:....:.|.: .||..:.:..|......|
Human  3550 PYSLEASPLGQLMNMLSHPVIRRSSLLTEKLLRLLSLISIALPENK-VSEAQANSGSGASSTTTA 3613

  Fly   228 TN--------AGETSAQP--HPFPTGGHDALPAGW--EERQDANGRTYYVNHTARTTQWDRPTVL 280
            |:        |..|:..|  .|.|.....||.|..  .....|...|.....||.||....||..
Human  3614 TSTTSTTTTTAASTTPTPPTAPTPVTSAPALVAATAISTIVVAASTTVTTPTTATTTVSISPTTK 3678

  Fly   281 NSHS--------SQSTDDQLASD--FQRRFHISVDDTESGRSADSISHNSIEDN----------- 324
            .|.|        |.|||.::.|.  .:.:..:||:...|    .|.|...:||.
Human  3679 GSKSPAKVSDGGSSSTDFKMVSSGLTENQLQLSVEVLTS----HSCSEEGLEDAANVLLQLSRGD 3739

  Fly   325 ------------NNAAGLAYT-PKTAATSSAPPNTPTNNNGILAQ-----IAMQYRAE------- 364
                        |.|..|.|| .|...|             :||:     :..|.||:
Human  3740 SGTRDTVLKLLLNGARHLGYTLCKQIGT-------------LLAELREYNLEQQRRAQCETLSPD 3791

  Fly   365 ---EDQDPT------------VDHTSFVYNSLRHPVAHRQPEI-------SATSLQNDLRPVREA 407
               |:|..|            :.....:..|.:.|:..|:.::       |.||.|.....|.:.
Human  3792 GLPEEQPQTTKLKGKMQSRFDMAENVVIVASQKRPLGGRELQLPSMSMLTSKTSTQKFFLRVLQV 3856

  Fly   408 PGVPDIAITNPFTRRA--AGNMAGGAGWQQERRRQQMQLHIQQHQQRQQQQQQNRILLDVDHRQQ 470
                 |......||||  .....|..|.........:|..:     ||.:.:.:.|:..|
Human  3857 -----IIQLRDDTRRANKKAKQTGRLGSSGLGSASSIQAAV-----RQLEAEADAIIQMV----- 3906

  Fly   471 EPQHRGQRHQQQHRPSNEDTDHTDS-----HNPSDISAPSTRRNSEEDNAAV-----PPMEQNTG 525
               ..|||.::|.:.:..::..:::     .:|.|:..||.   |.:|..::     |..|:
Human  3907 ---REGQRARRQQQAATSESSQSEASVRREESPMDVDQPSP---SAQDTQSIASDGTPQGEK--- 3962

  Fly   526 GEEEPLPPR-------------WSM------------------QVAPNGRTFFIDHASRRTTWID 559
             |:|..||.             |.|                  .:.|....||:.||:.|.:...
Human  3963 -EKEERPPELPLLSEQLSLDELWDMLGECLKELEESHDQHAVLVLQPAVEAFFLVHATERESKPP 4026

  Fly   560 PRNGRASPMPNQTRRVEDDLGPL---------PEGWEERVHTDGRVFYIDHNT------------ 603
            .|:.|.|    |...::|:..||         |...:.....:....:|..:.
Human  4027 VRDTRES----QLAHIKDEPPPLSPAPLTPATPSSLDPFFSREPSSMHISSSLPPDTQKFLRFAE 4087

  Fly   604 --RTTQWEDPRLSNPNIA----GQAVPYSR--DYKQKYEYFKSHIRKPTNVPNK--FEIRIRRTS 658
              ||...:..|.|..::|    ...|.|.|  |:..|.:||:..:.:......|  ..:.:||..
Human  4088 THRTVLNQILRQSTTHLADGPFAVLVDYIRVLDFDVKRKYFRQELERLDEGLRKEDMAVHVRRDH 4152

  Fly   659 ILEDSYRIISSVTKTDLLKTKLWVEFEGETGLDYGGLAREWFYLLSKEMFNPYYGLFEYSAMDNY 723
            :.|||||.:...:..: :|.:|::.||||.|.|.|||.|||:.::|:|||||.|.||..|..|..
Human  4153 VFEDSYRELHRKSPEE-MKNRLYIVFEGEEGQDAGGLLREWYMIISREMFNPMYALFRTSPGDRV 4216

  Fly   724 TLQINNGSGLCNEEHLSYFKFIGRIAGMAVYHGKLLDAFFIRPFYKMMLQKPIDLKDMESVDTEY 788
            |..||..|. ||..|||||||:|||...|||..:||:.:|.|.|||.:|.|.:...||||.|..:
Human  4217 TYTINPSSH-CNPNHLSYFKFVGRIVAKAVYDNRLLECYFTRSFYKHILGKSVRYTDMESEDYHF 4280

  Fly   789 YNSLMWIKENDPRIL--ELTFCLDEDVFGQKSQHELKPGGANIDVTNENKDEYIKLVIEWRFVAR 851
            |..|:::.|||...|  :|||..:...||.....:|||.||||.||.|||.||:.||.:.|....
Human  4281 YQGLVYLLENDVSTLGYDLTFSTEVQEFGVCEVRDLKPNGANILVTEENKKEYVHLVCQMRMTGA 4345

  Fly   852 VKEQMSSFLDGFGSIIPLNLIKIFDEHELELLMCGIQNIDVKDWRENTLYKGDYHMNHIIIQWFW 916
            :::|:::||:||..|||..||.||.|.|||||:.|:..||:.|.:.||.|. .|..|.|.|||||
Human  4346 IRKQLAAFLEGFYEIIPKRLISIFTEQELELLISGLPTIDIDDLKSNTEYH-KYQSNSIQIQWFW 4409

  Fly   917 RAVLSFSNEMRSRLLQFVTGTSRVPMNGFKELYGSNGPQMFTIEKWG-TPNNFPRAHTCFNRLDL 980
            ||:.||....|::.||||||||:||:.||..|.|.||.|.|.|.:.. :.:..|.||||||:|||
Human  4410 RALRSFDQADRAKFLQFVTGTSKVPLQGFAALEGMNGIQKFQIHRDDRSTDRLPSAHTCFNQLDL 4474

  Fly   981 PPYEGYLQLKDKLIKAI-EGSQGF 1003
            |.||.:.:|:..|:.|| |.|:||
Human  4475 PAYESFEKLRHMLLLAIQECSEGF 4498

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nedd4	NP_648993.1	C2_NEDD4_NEDD4L	71..204	CDD:175999	9/40 (23%)
		WW	248..277	CDD:278809	8/30 (27%)
		WW	531..560	CDD:278809	10/59 (17%)
		WW	581..613	CDD:197736	6/54 (11%)
		HECTc	650..1003	CDD:238033	169/356 (47%)
		HECTc	674..1003	CDD:214523	162/332 (49%)
HUWE1	XP_016884680.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810