DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nedd4 and nedd4

DIOPT Version :9

Sequence 1:	NP_648993.1	Gene:	Nedd4 / 39958	FlyBaseID:	FBgn0259174	Length:	1007	Species:	Drosophila melanogaster
Sequence 2:	XP_031755033.1	Gene:	nedd4 / 100496333	XenbaseID:	XB-GENE-478443	Length:	1283	Species:	Xenopus tropicalis

Alignment Length:	1023	Identity:	456/1023 - (44%)
Similarity:	575/1023 - (56%)	Gaps:	196/1023 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 SVAGGDVPRPPPRRRAASVAGQQQTRQEFGNGYTPRRSLAAVNDSGDSCHLRIVVLTGQSLAKKD 86
            ||:.|    ||.:|.:||                   ||...:....|.:|.|....|.
Frog   420 SVSEG----PPQKRSSAS-------------------SLKCRHPKSGSSYLHIQFAPGN------ 455

  Fly    87 IFGASDPYVRIDLNTINGDINIDSVLTKTKKKTLNPTWNEEFIFRVKPSEHKLVFQVFDENRLTR 151
                                  :|.::..||::|.....|   ...|||...|         .||
Frog   456 ----------------------ESRISSYKKQSLRSPTTE---LPGKPSVKLL---------KTR 486

  Fly   152 DDFLGMVELTLVNLPTEQEGRTIGEQSYT-----LRPRRSVGAKSRIKGTLRIYHAFIRETREQS 211
            |||||.|::.|..||||....   |:.||     |.||   ..|||:||.||:...::.:
Frog   487 DDFLGQVDVPLHQLPTENPRL---ERPYTFKDFILHPR---SHKSRVKGNLRLKMTYLPK----- 540

  Fly   212 EPSSGNSDGEWEHVEATNAG-------ETSAQPH------PFPTGGHDALPAGWEERQDANGRTY 263
              ::|:.|...|..|....|       :||.||.      |        ||.|||||||..||||
Frog   541 --NNGSEDENAEQAEEMEPGWVILDQPDTSCQPQQEQELSP--------LPPGWEERQDILGRTY 595

  Fly   264 YVNHTARTTQWDRPTV-----LNSHSSQSTDDQLASDFQRRFHISVDDTESGRSADS---ISHNS 320
            ||:|..|.|||.|||:     .|...:...::|....|..|..|| ::|||..|.:|   |:
Frog   596 YVSHQYRRTQWQRPTIQDDTAANESRNVQLEEQHHHAFTTRRQIS-EETESRDSPESWEIIT--- 656

  Fly   321 IEDNNNAAGLAYTPKTAATSSAPPNTPTNNNGILAQIAMQYRAEEDQDPTVDHTSFVYNSLRHPV 385
             ||...    .|:.:.|...|||  |......|..:::::.....:...:...:|.|:::.|..:
Frog   657 -EDETT----IYSNQNAQQGSAP--TSDAQAQITEELSIRLNISGNMPNSRQSSSNVHSNRRESL 714

  Fly   386 AHRQPEISATSLQNDLRPVREAPGVPDIAITNPFTRRAAGNMAG-GAGWQQERRRQQMQLHIQQH 449
            .      |.||        .|.|.||.:..|:          :| ..||:            ::|
Frog   715 Q------SYTS--------EELPTVPVLLPTS----------SGLPPGWE------------EKH 743

  Fly   450 QQRQQQQQQNRILLDVDHRQQEPQHRGQRHQQQHRPSNEDTDHTDSHNPSDIS------APSTRR 508
            ..:.:...       :||        ..|.....:||::....|::...|.:.      .|.|
Frog   744 DDKGRSYY-------IDH--------NSRTTTWEKPSSQAQGPTETFQTSSVQNVPVIFQPQT-- 791

  Fly   509 NSEEDNAAVPPMEQNTGGEEEPLPPRWSMQVAPNGRTFFIDHASRRTTWIDPRNGRASPMPNQTR 573
                   |.....|....|:..||..|.::.||.||.|:|:|.::.|||.|||    ..:|.|.|
Frog   792 -------ATRESTQLLETEQRFLPKGWEVRHAPTGRPFYINHVTKTTTWEDPR----LKIPVQLR 845

  Fly   574 RVE----DDLGPLPEGWEERVHTDGRVFYIDHNTRTTQWEDPRLSNPNIAGQAVPYSRDYKQKYE 634
            ...    .||||||.|||||.|.|||||||||||:.||||||||....|.|.|||||||||:|||
Frog   846 PKPPIDLSDLGPLPPGWEERTHNDGRVFYIDHNTKQTQWEDPRLQTAAITGPAVPYSRDYKRKYE 910

  Fly   635 YFKSHIRKPTNVPNKFEIRIRRTSILEDSYRIISSVTKTDLLKTKLWVEFEGETGLDYGGLAREW 699
            ||:..::|..::||:||:::|||:|||||||.|.:|.:.:.||.:||:||:.|.||||||:||||
Frog   911 YFRKKLKKQIDIPNRFEMKLRRTAILEDSYRRIIAVKRPEFLKARLWIEFDNEKGLDYGGVAREW 975

  Fly   700 FYLLSKEMFNPYYGLFEYSAMDNYTLQINNGSGLCNEEHLSYFKFIGRIAGMAVYHGKLLDAFFI 764
            |:|:||||||||||||||||.||||||||..||||||:||||||||||:||||||||||||||||
Frog   976 FFLISKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDAFFI 1040

  Fly   765 RPFYKMMLQKPIDLKDMESVDTEYYNSLMWIKENDPRILELTFCLDEDVFGQKSQHELKPGGANI 829
            ||||||||||||.|.||||||:||||||.||.||||..|:|.|.:||::|||..|||||.||:.|
Frog  1041 RPFYKMMLQKPIILYDMESVDSEYYNSLQWILENDPSGLDLCFTVDEELFGQTHQHELKAGGSQI 1105

  Fly   830 DVTNENKDEYIKLVIEWRFVARVKEQMSSFLDGFGSIIPLNLIKIFDEHELELLMCGIQNIDVKD 894
            .|||:||.|||.|||:|||:.||::||::|.:||..:||.:|||||||:||||||||:.::||.:
Frog  1106 LVTNKNKKEYIHLVIQWRFMNRVQKQMAAFKEGFFELIPQDLIKIFDENELELLMCGLGDVDVNN 1170

  Fly   895 WRENTLYKGDYHMNHIIIQWFWRAVLSFSNEMRSRLLQFVTGTSRVPMNGFKELYGSNGPQMFTI 959
            |||:|.||..|...|.:|||||:|||....|.|.|||||||||||||||||.|||||||||:||:
Frog  1171 WREHTKYKNGYSQGHQVIQWFWKAVLMMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTV 1235

  Fly   960 EKWGTPNNFPRAHTCFNRLDLPPYEGYLQLKDKLIKAIEGSQGFAGVD 1007
            ||||||...||||||||||||||||.:..|.|||..|||.:|||.|||
Frog  1236 EKWGTPEKLPRAHTCFNRLDLPPYESFEDLWDKLHIAIENAQGFDGVD 1283

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nedd4	NP_648993.1	C2_NEDD4_NEDD4L	71..204	CDD:175999	38/137 (28%)
		WW	248..277	CDD:278809	20/28 (71%)
		WW	531..560	CDD:278809	13/28 (46%)
		WW	581..613	CDD:197736	26/31 (84%)
		HECTc	650..1003	CDD:238033	252/352 (72%)
		HECTc	674..1003	CDD:214523	238/328 (73%)
nedd4	XP_031755033.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	468	1.000	Domainoid score	I453
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	764	1.000	Inparanoid score	I543
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D142537at33208
OrthoFinder	1	1.000	-	-		FOG0000080
OrthoInspector	1	1.000	-	-		otm48846
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1682
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.060