DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nedd4 and smurf1

DIOPT Version :9

Sequence 1:	NP_648993.1	Gene:	Nedd4 / 39958	FlyBaseID:	FBgn0259174	Length:	1007	Species:	Drosophila melanogaster
Sequence 2:	XP_002931540.1	Gene:	smurf1 / 100491582	XenbaseID:	XB-GENE-479046	Length:	731	Species:	Xenopus tropicalis

Alignment Length:	981	Identity:	305/981 - (31%)
Similarity:	424/981 - (43%)	Gaps:	288/981 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 SLAAVNDSGDSCHLRIVVLTGQSLAKKDIFGASDPYVRIDLNTINGDINIDSVLTKTKKKTLNPT 123
            |.|.....|.|..:|:.||..::|||:|.|...||:.:|   .::|.....|  |.|.|.||:|.
Frog     2 SNAVTRRGGSSIRVRLTVLCAKNLAKRDFFRLPDPFAKI---VVDGSGQCHS--TDTVKNTLDPK 61

  Fly   124 WNEEFIFRVKPSEHKLVFQVFDENRLTRDD---FLGMVELTLVNLPTEQEGRTIGEQSYTLRPRR 185
            ||:.:...|...: .:...:::..::.:..   |||.|.| |.|
Frog    62 WNQHYDLYVGKMD-SITISIWNHKKIHKKQGAGFLGCVRL-LSN--------------------- 103

  Fly   186 SVGAKSRIKGTLRIYHAFIRETREQSEPSSGNSDGEWEHVEATNAGETSAQPHPFPTGGHDALPA 250
               |.||:|.|                                               |:..|..
Frog   104 ---AISRLKDT-----------------------------------------------GYQRLDL 118

  Fly   251 GWEERQDANGRTYYVNHTARTTQWDRPTVLNSHSSQSTDDQLASDFQRRFHISVDDTESGRSADS 315
                                       ..||...|.:...|:....|.|..|       |.....
Frog   119 ---------------------------CKLNPADSDAVRGQIVVSLQTRDRI-------GTVGSV 149

  Fly   316 ISHNSIEDNNNAAGLAYTPKTAATSSAPPNTPTNNNGILAQIAMQYRAEEDQDPTVDHTSFVYNS 380
            :....:.||:   |..|       ..|.|..|
Frog   150 VDCRGLLDND---GALY-------EDAGPGRP--------------------------------- 171

  Fly   381 LRHPVAHRQPEISATSLQNDLRPVREAPGVPDIAITNPFTRRAAGNMAGGAGWQQERRRQQMQLH 445
                         .:...::..|..:.||             |||   ||.....|...|:.:|.
Frog   172 -------------LSCFMDEPAPYTDGPG-------------AAG---GGPCRLVESPGQEQRLQ 207

  Fly   446 IQQHQQRQQQQQQNRILLDVDHRQQEPQHRGQRHQQQHRPSNEDTDHTDSHNPSDISAPSTRRNS 510
            .|                    |.:.|:.|               :|..:
Frog   208 AQ--------------------RLRGPEVR---------------EHVQT--------------- 222

  Fly   511 EEDNAAVPPMEQNTGGEEEPLPPRWSMQVAPNGRTFFIDHASRRTTWIDPRNGRASPMPNQTRRV 575
                    |:.::.|.:.:.||..:..:....|:.:|:...:..:||.|||      :|.....|
Frog   223 --------PLNRSHGYQSQDLPEGYEQRTTVQGQVYFLHTQTGVSTWHDPR------IPRDLNSV 273

  Fly   576 E-DDLGPLPEGWEERVHTDGRVFYIDHNTRTTQWEDPR----------LSNPNIA---------- 619
            . |||||||.|||.|....||::::|||.||||:.|||          |..||.|
Frog   274 NCDDLGPLPTGWEVRTTVSGRIYFVDHNNRTTQFTDPRLHHIINHQSQLKEPNNAIPVQSDGSLE 338

  Fly   620 -GQAVP---YSRDYKQKYEYFKSHIRKPTNVPNKFEIRIRRTSILEDSYRIISSVTKTDLLKTKL 680
             |...|   |.||..||.:..:..:...........:.:.|..|.|:|||.|..:...| ||.:|
Frog   339 EGDEFPTQRYERDLVQKLKVLRHELSLLQPQAGHCRVEVSREEIFEESYRQIMKMRPKD-LKKRL 402

  Fly   681 WVEFEGETGLDYGGLAREWFYLLSKEMFNPYYGLFEYSAMDNYTLQINNGSGLCNEEHLSYFKFI 745
            .|:|.||.||||||:||||.|||..||.|||||||:||..:.||||||..|.: |.:|||||.|:
Frog   403 MVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYTLQINPDSSI-NPDHLSYFHFV 466

  Fly   746 GRIAGMAVYHGKLLDAFFIRPFYKMMLQKPIDLKDMESVDTEYYNSLMWIKEND-PRILELTFCL 809
            |||.|:||:||..::..|..||||.:|.|||.|.|:||||.|.:.||:||.||| ..:|:.|||:
Frog   467 GRIMGLAVFHGHYINGGFTVPFYKQLLGKPIQLSDLESVDPELHKSLVWILENDITSVLDHTFCV 531

  Fly   810 DEDVFGQKSQHELKPGGANIDVTNENKDEYIKLVIEWRFVARVKEQMSSFLDGFGSIIPLNLIKI 874
            :.:.||:..||||||.|.|:.||.|||.||::|.:.|||:..::.|..:...||..:||.:|:|.
Frog   532 EHNAFGRLLQHELKPNGKNLQVTEENKKEYVRLYVNWRFMRGIEAQFLALQKGFNELIPQHLLKP 596

  Fly   875 FDEHELELLMCGIQNIDVKDWRENTLYKGDYH--MNHIIIQWFWRAVLSFSNEMRSRLLQFVTGT 937
            |::.||||::.|:..||:.||:.||..|   |  .|..|:||||:||.||..|.|:||||||||:
Frog   597 FEQKELELIIGGLDKIDISDWKANTRLK---HCLANSNIVQWFWQAVESFDEERRARLLQFVTGS 658

  Fly   938 SRVPMNGFKELYGSN---GPQMFTIEKW-GTPNNFPRAHTCFNRLDLPPYEGYLQLKDKLIKAIE 998
            :|||:.|||.|.||.   ||::|||... ...:|.|:|||||||:|:||||.|.:|.:||:.|:|
Frog   659 TRVPLQGFKALQGSTGAAGPRLFTIHLIDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVE 723

  Fly   999 GSQGFA 1004
            .:.|||
Frog   724 ETSGFA 729

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nedd4	NP_648993.1	C2_NEDD4_NEDD4L	71..204	CDD:175999	34/135 (25%)
		WW	248..277	CDD:278809	1/28 (4%)
		WW	531..560	CDD:278809	6/28 (21%)
		WW	581..613	CDD:197736	19/41 (46%)
		HECTc	650..1003	CDD:238033	184/359 (51%)
		HECTc	674..1003	CDD:214523	177/335 (53%)
smurf1	XP_002931540.1	C2_Smurf-like	14..138	CDD:176028	40/228 (18%)
		WW	234..266	CDD:197736	9/37 (24%)
		WW	280..312	CDD:197736	18/31 (58%)
		HECTc	373..728	CDD:238033	184/359 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000080
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000