Protein Alignment Nedd4 and smurf1

DIOPT Version :10

• Sequence 1: NP_648993.1
• Gene: Nedd4 / 39958
• FlyBaseID: FBgn0259174
• Length: 1007
• Species: Drosophila melanogaster
• Sequence 2: XP_002931540.1
• Gene: smurf1 / 100491582
• XenbaseID: XB-GENE-479046
• Length: 731
• Species: Xenopus tropicalis
• Alignment Length: 981
• Identity: 305/981 - (31%)
• Similarity: 424/981 - (43%)
• Gaps: 288/981 - (29%)

  Fly    59 SLAAVNDSGDSCHLRIVVLTGQSLAKKDIFGASDPYVRIDLNTINGDINIDSVLTKTKKKTLNPT 123
            |.|.....|.|..:|:.||..::|||:|.|...||:.:|   .::|.....|  |.|.|.||:|.
 Frog     2 SNAVTRRGGSSIRVRLTVLCAKNLAKRDFFRLPDPFAKI---VVDGSGQCHS--TDTVKNTLDPK 61

  Fly   124 WNEEFIFRVKPSEHKLVFQVFDENRLTRDD---FLGMVELTLVNLPTEQEGRTIGEQSYTLRPRR 185
            ||:.:...|...: .:...:::..::.:..   |||.|.| |.|
 Frog    62 WNQHYDLYVGKMD-SITISIWNHKKIHKKQGAGFLGCVRL-LSN--------------------- 103

  Fly   186 SVGAKSRIKGTLRIYHAFIRETREQSEPSSGNSDGEWEHVEATNAGETSAQPHPFPTGGHDALPA 250
               |.||:|.|                                               |:..|..
 Frog   104 ---AISRLKDT-----------------------------------------------GYQRLDL 118

  Fly   251 GWEERQDANGRTYYVNHTARTTQWDRPTVLNSHSSQSTDDQLASDFQRRFHISVDDTESGRSADS 315
                                       ..||...|.:...|:....|.|..|       |.....
 Frog   119 ---------------------------CKLNPADSDAVRGQIVVSLQTRDRI-------GTVGSV 149

  Fly   316 ISHNSIEDNNNAAGLAYTPKTAATSSAPPNTPTNNNGILAQIAMQYRAEEDQDPTVDHTSFVYNS 380
            :....:.||:   |..|       ..|.|..|
 Frog   150 VDCRGLLDND---GALY-------EDAGPGRP--------------------------------- 171

  Fly   381 LRHPVAHRQPEISATSLQNDLRPVREAPGVPDIAITNPFTRRAAGNMAGGAGWQQERRRQQMQLH 445
                         .:...::..|..:.||             |||   ||.....|...|:.:|.
 Frog   172 -------------LSCFMDEPAPYTDGPG-------------AAG---GGPCRLVESPGQEQRLQ 207

  Fly   446 IQQHQQRQQQQQQNRILLDVDHRQQEPQHRGQRHQQQHRPSNEDTDHTDSHNPSDISAPSTRRNS 510
            .|                    |.:.|:.|               :|..:
 Frog   208 AQ--------------------RLRGPEVR---------------EHVQT--------------- 222

  Fly   511 EEDNAAVPPMEQNTGGEEEPLPPRWSMQVAPNGRTFFIDHASRRTTWIDPRNGRASPMPNQTRRV 575
                    |:.::.|.:.:.||..:..:....|:.:|:...:..:||.|||      :|.....|
 Frog   223 --------PLNRSHGYQSQDLPEGYEQRTTVQGQVYFLHTQTGVSTWHDPR------IPRDLNSV 273

  Fly   576 E-DDLGPLPEGWEERVHTDGRVFYIDHNTRTTQWEDPR----------LSNPNIA---------- 619
            . |||||||.|||.|....||::::|||.||||:.|||          |..||.|
 Frog   274 NCDDLGPLPTGWEVRTTVSGRIYFVDHNNRTTQFTDPRLHHIINHQSQLKEPNNAIPVQSDGSLE 338

  Fly   620 -GQAVP---YSRDYKQKYEYFKSHIRKPTNVPNKFEIRIRRTSILEDSYRIISSVTKTDLLKTKL 680
             |...|   |.||..||.:..:..:...........:.:.|..|.|:|||.|..:...| ||.:|
 Frog   339 EGDEFPTQRYERDLVQKLKVLRHELSLLQPQAGHCRVEVSREEIFEESYRQIMKMRPKD-LKKRL 402

  Fly   681 WVEFEGETGLDYGGLAREWFYLLSKEMFNPYYGLFEYSAMDNYTLQINNGSGLCNEEHLSYFKFI 745
            .|:|.||.||||||:||||.|||..||.|||||||:||..:.||||||..|.: |.:|||||.|:
 Frog   403 MVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYTLQINPDSSI-NPDHLSYFHFV 466

  Fly   746 GRIAGMAVYHGKLLDAFFIRPFYKMMLQKPIDLKDMESVDTEYYNSLMWIKEND-PRILELTFCL 809
            |||.|:||:||..::..|..||||.:|.|||.|.|:||||.|.:.||:||.||| ..:|:.|||:
 Frog   467 GRIMGLAVFHGHYINGGFTVPFYKQLLGKPIQLSDLESVDPELHKSLVWILENDITSVLDHTFCV 531

  Fly   810 DEDVFGQKSQHELKPGGANIDVTNENKDEYIKLVIEWRFVARVKEQMSSFLDGFGSIIPLNLIKI 874
            :.:.||:..||||||.|.|:.||.|||.||::|.:.|||:..::.|..:...||..:||.:|:|.
 Frog   532 EHNAFGRLLQHELKPNGKNLQVTEENKKEYVRLYVNWRFMRGIEAQFLALQKGFNELIPQHLLKP 596

  Fly   875 FDEHELELLMCGIQNIDVKDWRENTLYKGDYH--MNHIIIQWFWRAVLSFSNEMRSRLLQFVTGT 937
            |::.||||::.|:..||:.||:.||..|   |  .|..|:||||:||.||..|.|:||||||||:
 Frog   597 FEQKELELIIGGLDKIDISDWKANTRLK---HCLANSNIVQWFWQAVESFDEERRARLLQFVTGS 658

  Fly   938 SRVPMNGFKELYGSN---GPQMFTIEKW-GTPNNFPRAHTCFNRLDLPPYEGYLQLKDKLIKAIE 998
            :|||:.|||.|.||.   ||::|||... ...:|.|:|||||||:|:||||.|.:|.:||:.|:|
 Frog   659 TRVPLQGFKALQGSTGAAGPRLFTIHLIDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVE 723

  Fly   999 GSQGFA 1004
            .:.|||
 Frog   724 ETSGFA 729

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nedd4	NP_648993.1	C2_NEDD4_NEDD4L	71..204	CDD:175999	34/135 (25%)
		WW	248..277	CDD:459800	1/28 (4%)
		HUL4	<523..1003	CDD:227354	230/511 (45%)
smurf1	XP_002931540.1	C2_Smurf-like	14..138	CDD:176028	40/228 (18%)
		WW	234..266	CDD:197736	9/37 (24%)
		WW	280..312	CDD:197736	18/31 (58%)
		HECTc	373..728	CDD:238033	184/359 (51%)