Protein Alignment Nedd4 and herc6

DIOPT Version :10

• Sequence 1: NP_648993.1
• Gene: Nedd4 / 39958
• FlyBaseID: FBgn0259174
• Length: 1007
• Species: Drosophila melanogaster
• Sequence 2: XP_031759089.1
• Gene: herc6 / 100487734
• XenbaseID: XB-GENE-968556
• Length: 1030
• Species: Xenopus tropicalis
• Alignment Length: 915
• Identity: 185/915 - (20%)
• Similarity: 318/915 - (34%)
• Gaps: 266/915 - (29%)

  Fly   201 HAFIRETREQSEPSSGNSDGEWEHVEATNAGETSAQPHPFPTGGHDALPAGWEERQDANGRTY-- 263
            :.|..:|..|...:|||.....:.:| ..||:.|                     |.|.||.:
 Frog   267 YTFGDDTHGQLGQNSGNQTSVPQKIE-DYAGQVS---------------------QVACGRYHTL 309

  Fly   264 -YVNHTARTTQWDRPTVLNSHSSQSTDD-QLASDFQRRFHISVDDTESGRSADSISHNSIED--- 323
             ||....|...:.:.::....:::.:|: :|.|:|         |..|     .:..|.:.|
 Frog   310 LYVFSCNRIVSFGKGSLRPQDNTECSDEAELPSEF---------DISS-----LVPTNDLRDVYV 360

  Fly   324 ----NNNAAGLAY-------TPKTAATSSAPP----NTPTNNNGILAQIAMQYRAEEDQ------ 367
                ..|..|.|.       |.:|..:.:..|    :.||....:.||..    :||.|
 Frog   361 KWIFAGNNVGFAVPFSQQEATKRTLLSDTFKPILRLDLPTIKKWMKAQTG----SEEYQIAKREI 421

  Fly   368 -----DPTVDHTSFVYNSLRHPVA--------------------HRQPEISATSLQNDLRP---- 403
                 .|......||..|..:..:                    .|..:|..:|::|||.|
 Frog   422 CTIFSSPACFTAGFVNRSSSNTSSASSIVDLGVASKLFTELIKDRRISDIICSSIRNDLIPELES 486

  Fly   404 -------------VREAPGVPDIAITNPFT---RRAAGNMAG------GAGWQQERRRQQMQLHI 446
                         :.|.|.:.|::|.....   .:|..||..      |..|.          |:
 Frog   487 LPLLYEAFAIFLLLPECPLLHDLSICLSVVVALAKAINNMGESSLKILGTLWS----------HM 541

  Fly   447 QQHQQRQQ-QQQQNRILLDVDHRQQEPQHRGQRHQQQHRPSNEDTDHTDSHNPSDISAPSTRRNS 510
            |.....:| |..:..::|.:...|.||   |.:...|                   ......:.:
 Frog   542 QASSMTKQIQLLKIAVILSIQGIQAEP---GTKDLLQ-------------------MLKKLYKAN 584

  Fly   511 EEDNAAVPPMEQNTGGEEEPLPPRWSMQVAPNGRTFFIDHASRRTTWIDPRNGRASPMPNQTRRV 575
            .:.|..||   .|.....|..|    :.:.|                :|..|.|.
 Frog   585 LKGNCIVP---INAFCMNELCP----LIILP----------------LDVNNWRL---------- 616

  Fly   576 EDDLGPLPEGWEERVHTDGR-----------VFYIDHNTRTTQWEDPRLSNPNIAGQAVPYSRDY 629
                      |:.:...|..           ||......:....:..|..|          :..:
 Frog   617 ----------WQSQPEPDENAFPAIYCRFPFVFNFPTKVQALHLDSMRKRN----------NEKF 661

  Fly   630 KQKYEYFKSHIRKPTNVPN--KFEIRIRRTSILEDSYRIISSVTKTDLLKTKLWVEFEGETGLDY 692
            :.:.:..::.::..:::||  ...:.:||..:|||:...:|.|...: ||..|.|||:||:..|.
 Frog   662 QAQEQLVRNRLQGISDLPNIPLLHLILRRGHLLEDTLHKLSIVEDPN-LKKDLLVEFQGESTTDS 725

  Fly   693 GGLAREWFYLLSKEMFNPYYGLFEYSAMDNYTLQINNGSGLCNE-------------EHLSYFKF 744
            ..:.:|:|.:|.:.|.||.||:|.                 |::             |...||.|
 Frog   726 AAVTKEFFLVLLESMVNPDYGMFS-----------------CSDPLLPIWFPSTPLVEKKKYFYF 773

  Fly   745 IGRIAGMAVYHGKLLDAFFIRPFYKMMLQKPIDLKDMESVDTEYYNSLMWIKENDPRI---LELT 806
             |.|.|:|||:..::...|....:|.:|.|...|:|::.:......::..:.:.:..:   :|..
 Frog   774 -GIICGLAVYNQIVIYLPFPLALFKKLLGKKATLEDLKELQPTMGRTMKDLLDAESTVVESMETY 837

  Fly   807 FCLDEDVFGQKSQHELKPGGANIDVTNENKDEYIKLVIEWRFVARVKEQMSSFLDGFGSIIPLNL 871
            ||...|    ....:|.|.|.::.|.|.||.:::...|::.|...|......|..||..:....:
 Frog   838 FCFSWD----NKSIDLIPNGGSVQVNNLNKKDFVNKCIDYIFNTSVMVPFEEFKRGFYKVCDKEI 898

  Fly   872 IKIFDEHELELLMCGIQNIDVKDWRENTLYKGDYHMNHIIIQWFWRAVLSFSNEMRSRLLQFVTG 936
            |..|...||..|:.|....|...:.:.|:|.|.:..:|..|:.||:...:.|...:...|.|:||
 Frog   899 ISFFQPDELMALVAGTTEYDWNIFEKTTMYLGKFTPDHPTIRMFWKVFHALSLVNKKGFLMFLTG 963

  Fly   937 TSRVPMNGFKELYGSNGPQM-FTIEKWGTPN--NFPRAHTCFNRLDLPPYEGYLQLKDKLIKAIE 998
            ..::|      ::...|..: ..|..:|.|:  :.|.|.|||:.|.||.|.....||.||:.||.
 Frog   964 NDKLP------IFTRGGDNIRMKISSFGVPDETHLPEAQTCFHMLFLPEYSNIKSLKQKLMLAIA 1022

  Fly   999 GSQGF 1003
            .::|:
 Frog  1023 HNKGY 1027

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nedd4	NP_648993.1	C2_NEDD4_NEDD4L	71..204	CDD:175999	0/2 (0%)
		WW	248..277	CDD:459800	7/31 (23%)
		HUL4	<523..1003	CDD:227354	113/511 (22%)
herc6	XP_031759089.1	ATS1	1..309	CDD:444065	14/63 (22%)
		HUL4	324..1021	CDD:227354	165/828 (20%)
		HECTc	684..1028	CDD:238033	99/373 (27%)