DRSC/TRiP Functional Genomics Resources

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Protein Alignment Nedd4 and hecw2b

DIOPT Version :9

Sequence 1:NP_648993.1 Gene:Nedd4 / 39958 FlyBaseID:FBgn0259174 Length:1007 Species:Drosophila melanogaster
Sequence 2:XP_003197660.3 Gene:hecw2b / 100331355 ZFINID:ZDB-GENE-101001-3 Length:1472 Species:Danio rerio


Alignment Length:1341 Identity:361/1341 - (26%)
Similarity:508/1341 - (37%) Gaps:472/1341 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly    71 HLRIVV------LTGQSLAKKDIFGASDPYVRIDLN----------TINGDINIDSVLTKTKKKT 119
            |.|.:|      :..|.| ||.:|...|||:::.:.          :.:|.....|:::    .|
Zfish   193 HCRKLVSFTLSDIRAQGL-KKGMFFNPDPYLKMSIQPGKRNGFPTFSHHGQERRTSIIS----NT 252

  Fly   120 LNPTWNEEFIFRVKPSEHKLVFQV---FDENRLTRDDFLGMVELTLVNLPTEQEGRTIGEQ--SY 179
            .||.|:.|....|......|..:|   |.::|.....|||.:.:.:..|   .|..|.|:|  ||
Zfish   253 TNPVWHGEKYTFVALMTDVLEIEVKDKFAKSRPIIKRFLGQLIIPVQRL---LERHTAGDQHVSY 314

  Fly   180 TLRPRRSVGAKSRIKGTLRIYHAFIRETREQSEPSSGNSDGEWEHVEATNA-------GETSAQP 237
            ||..|...   ..:.|.|   |..:..|....|.:.|:..|    ..|.|.       .|...||
Zfish   315 TLCRRLPT---EHVSGQL---HFRVEITFNGHEDAMGSLLG----ASAMNGDPGSPSDDEDVLQP 369

  Fly   238 ------HPFPTGGHDAL-------------PAGWEERQDANGRTYYVN----HTARTTQ------ 273
                  .|.|||...:|             |.  |:|...:|......    ||.|.:.      
Zfish   370 VSRMVRGPSPTGSEGSLHGDAFRPDECMMDPE--EDRLLRDGAPDLAEGAPAHTHRQSSLNDYLD 432

  Fly   274 --------WDRPTVLNS---HSSQSTDDQLASDFQRRFHISVDDTESGRSADSIS---------- 317
                    .|||...:|   .||..||.:|    ....||..|:.|.|.::...:          
Zfish   433 AIEAPKPPGDRPLGASSPKLRSSFPTDTRL----NAMLHIDSDEDEEGHASRDTALTNGMPRPEG 493

  Fly   318 HNSIE--------------DNNNAAGLAYTPKTAATSSAPPNTPTNNNGILAQIAMQYRAEEDQD 368
            |.|.|              ::..|:....|..||:.||:......|..|          ||..|:
Zfish   494 HASSERGKGEVHVKNRERLESEAASSATDTEATASVSSSGTTKSQNGGG----------AEGGQE 548

  Fly   369 P-------TVDHTSFVYNSLR-------HPVAHRQPEISATSLQNDLRPVREAPGVPDIAITNPF 419
            .       |...:||...:||       .|.|..:.|.|:           |||.|.:.:.:..:
Zfish   549 GAAISGGLTQSISSFQQPALRIQDEEGAAPQASSRTEGSS-----------EAPAVSEASASAIY 602

  Fly   420 TRRAAGNMAGGAGWQQERRRQQMQLHIQQHQQRQQQQQQNRILLDVDHRQQEPQHRGQRHQQQHR 484
            |....|   |.....|..|....::..|:.:..:..|::..:....:..|.|....|   .:..|
Zfish   603 TVNEVG---GATATNQPERMNSSEMTNQEEEDEEIWQRRRSLQASGNESQAEAMELG---NEVRR 661

  Fly   485 PSNED-----TD-------HTDSHNPSDISAPSTRRNSEEDNAAVPPMEQNTGGEEEPLPPRWSM 537
            .::|.     ||       ..:.|.|.. |.||.|.:.......           :|||||.|..
Zfish   662 TADEAQAALITDGETGACAQVNGHQPMR-SLPSVRHDISRYQRV-----------DEPLPPNWEA 714

  Fly   538 QVAPNGRTFFIDHASRRTTWIDP----------RNGRASPMPNQTRRVE---------------- 576
            ::..:||.|::||.:|.|||..|          |:.....|....||.:                
Zfish   715 RIDSHGRIFYVDHVNRTTTWQRPTAPPAPQVLQRSNSIQQMEQLNRRYQSIRRTITNERTEEQAA 779

  Fly   577 ----DDL-------------------GP------------------------------------- 581
                |||                   ||                                     
Zfish   780 EMPPDDLTTSDLLHHSIPEYRRDGVVGPASSRSRLTLLLQSPSAKFLTSPDFFTVLHSNPSAYRM 844

  Fly   582 -------------------------------------------LPEGWEERVHTDGRVFYIDHNT 603
                                                       ||.|||.:....|:.|::|||.
Zfish   845 FTSNTCLKHMISKVRRDAHHFERYQHNRDLVAFLNMFANKQLDLPRGWEMKHDHTGKPFFVDHNC 909

  Fly   604 RTTQWEDPRL-----------------------------SNPNIAGQAV---------------- 623
            |.|.:.||||                             .:|..||.||                
Zfish   910 RATTFIDPRLPLQSARPSSLLAHRQHLSRQRSHSAGEVGDDPRHAGPAVLPRPSNTFTANRNQCQ 974

  Fly   624 ----------------------------------------------------------------- 623
                                                                             
Zfish   975 DLVPVAYNEKIVAFLRQPNIFDILQERQPELIRNHSLREKVQFIRNEGASGLARLSSDADLVILL 1039

  Fly   624 ------------------------------------------------PYSRDYKQKYE--YFKS 638
                                                            ||.||::.|..  |.|.
Zfish  1040 SLFEEEVMSYVPPHALLHPSYCQSPRGSPVSSPQNSPGTQRANARAPAPYKRDFEAKLRNFYRKL 1104

  Fly   639 HIRKPTNVPNKFEIRIRRTSILEDSYRIISSVTKTDLLKTKLWVEFEGETGLDYGGLAREWFYLL 703
            ..:.....|.|.::.|||..:|||::..|...::.||.::||:|.|.||.||||.|.:||:|:|:
Zfish  1105 ETKGYGQGPGKVKLIIRRDHLLEDAFNQIMCYSRKDLQRSKLYVSFVGEEGLDYSGPSREFFFLV 1169

  Fly   704 SKEMFNPYYGLFEYSAMDNYTLQINNGSGLCNEEHLSYFKFIGRIAGMAVYHGKLLDAFFIRPFY 768
            |:|:||||||||||||.|.||:||:..|...:..| .:|:|.|||.|:|:.|..||||||.||||
Zfish  1170 SRELFNPYYGLFEYSANDTYTVQISPMSAFVDNHH-EWFRFSGRILGLALIHQYLLDAFFTRPFY 1233

  Fly   769 KMMLQKPIDLKDMESVDTEYYNSLMWIKEND-PRILELTFCLDEDVFGQKSQHELKPGGANIDVT 832
            |.:|:.|.||.|:|.:|.|::.||.|:|:|| ..:|:|||.::|:||||.::.|||||||||.|:
Zfish  1234 KGLLRIPCDLSDLEYLDEEFHQSLQWMKDNDIEDMLDLTFTVNEEVFGQITERELKPGGANIPVS 1298

  Fly   833 NENKDEYIKLVIEWRFVARVKEQMSSFLDGFGSIIPLNLIKIFDEHELELLMCGIQNIDVKDWRE 897
            .:||.|||:.:::||....|.:|..|.:.||..::...|:.:||..||||::.|...||:.|||.
Zfish  1299 EKNKKEYIERMVKWRIERGVVQQTESLVRGFYEVVDARLVSVFDARELELVIAGTAEIDLGDWRN 1363

  Fly   898 NTLYKGDYHMNHIIIQWFWRAVLSFSNEMRSRLLQFVTGTSRVPMNGFKELYGSNGPQMFTIEKW 962
            ||.|:|.||.|||:|:|||.||..|:||.|.||||||||||.:|..||..|.|||||:.|.:|||
Zfish  1364 NTEYRGGYHDNHIVIRWFWAAVERFNNEQRLRLLQFVTGTSSIPYEGFASLRGSNGPRRFCVEKW 1428

  Fly   963 GTPNNFPRAHTCFNRLDLPPYEGYLQLKDKLIKAIEGSQGF 1003
            |...:.|||||||||||||||..:..|.:|::.|:|.:..|
Zfish  1429 GKITSLPRAHTCFNRLDLPPYPSFSMLYEKMLTAVEETSTF 1469

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Nedd4NP_648993.1 C2_NEDD4_NEDD4L 71..204 CDD:175999 39/153 (25%)
WW 248..277 CDD:278809 9/59 (15%)
WW 531..560 CDD:278809 13/28 (46%)
WW 581..613 CDD:197736 15/111 (14%)
HECTc 650..1003 CDD:238033 184/353 (52%)
HECTc 674..1003 CDD:214523 177/329 (54%)
hecw2bXP_003197660.3 HECW_N 58..177 CDD:318711
C2_NEDL1-like 198..334 CDD:176073 37/149 (25%)
LGT <491..633 CDD:320995 33/165 (20%)
WW 708..737 CDD:306827 13/28 (46%)
WW 887..919 CDD:197736 14/31 (45%)
HECTc 1117..1470 CDD:238033 185/354 (52%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000080
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
32.910

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