DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Nedd4 and itcha

DIOPT Version :9

Sequence 1:NP_648993.1 Gene:Nedd4 / 39958 FlyBaseID:FBgn0259174 Length:1007 Species:Drosophila melanogaster
Sequence 2:NP_001274024.1 Gene:itcha / 100331274 ZFINID:ZDB-GENE-120919-4 Length:851 Species:Danio rerio


Alignment Length:1042 Identity:335/1042 - (32%)
Similarity:470/1042 - (45%) Gaps:308/1042 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    72 LRIVVLTGQSLA-KKDIFGASDPYVRIDLNTINGDINIDSVLTKTKK--KTLNPTWNEEFIFRVK 133
            |:|.||:.:... ||:.||.| |||         ::.:|....||:|  .|.:|.|.:.....|.
Zfish     5 LQITVLSAKLRENKKNWFGPS-PYV---------EVFVDGQSKKTEKCTNTHSPKWKQSLTVIVT 59

  Fly   134 PSEHKLVFQVFDENRLTRDDFLGMVELTL-----------------VNLPTEQEGRT--IGEQSY 179
            |.. ||:|:|:....|..|..||:..|.:                 :.|.::: ||:  :|:.|.
Zfish    60 PFS-KLIFRVWSHQTLKADILLGVASLEVSETLKANNMKICEVVQTLQLSSDR-GRSEQVGDLSL 122

  Fly   180 TL---------------RPRRSVGAKSRIKG------------------TLRIYHAF-------- 203
            .|               :....|..:||:.|                  .|...||.        
Zfish   123 CLDGLQVDAETFASEEQKHNAVVNGESRLNGDAIRSRDSSPSSDITDDAPLPNGHAVGSSASASP 187

  Fly   204 -------IRETREQ-------------------SEPSSGNS------------DGEWEHVEATNA 230
                   .|..|.|                   |.|:.|:|            :||.|...:::.
Zfish   188 STGALRAPRPLRPQRPPPASPHKHTSSTASSTGSTPTHGSSAPSPEMSPRVCVNGETESQGSSSG 252

  Fly   231 GETSAQPHPFPTG------GHDALPAGWEERQDANGRTYYVNHTARTTQWDRPTVLNSHSSQSTD 289
            ..::..|...||.      .:..||.|||:|.|.|||.|||:|..:.|.|:||            
Zfish   253 SGSNQAPRASPTPPRAPAITNGPLPPGWEQRADQNGRVYYVDHIEKRTTWERP------------ 305

  Fly   290 DQLASDFQRRFHISVDDTESGRSADSISHNSIEDNNNAAGLAYTPKTAATSSAPPNTPTNNNGIL 354
            :.|...::||.                         :..|..|                      
Zfish   306 EPLPPGWERRL-------------------------DPMGRVY---------------------- 323

  Fly   355 AQIAMQYRAEEDQDPTVDHTSFVYNSLRHPVAHRQPEISATSLQNDLRPVREAPGVPDIAITNPF 419
                           .|||.:                 ..|:.|   ||..|             
Zfish   324 ---------------YVDHIN-----------------RTTTWQ---RPTLE------------- 340

  Fly   420 TRRAAGNMAGGAGWQQERRRQQMQLHIQQHQQRQQQQQQNRILLDVDHRQQEPQHRGQRHQQQHR 484
                  ::.....||.:  |.|:|..:|:..||.....|.::                       
Zfish   341 ------SVRNYEEWQNQ--RSQLQGAMQRFNQRFIYGLQEQL----------------------- 374

  Fly   485 PSNEDTDHTDSHNPSDISAPSTRRNSEEDNAAVPPMEQNTGGEEEPLPPRWSMQVAPNGRTFFID 549
                              ||:.  |.|.|     |:        .|||..|..:...|.|.:|:.
Zfish   375 ------------------APTA--NKEFD-----PL--------GPLPSGWEKRTDSNRRMYFVH 406

  Fly   550 HASRRTTWIDPRNGRASPMPNQTRRVEDDLGPLPEGWEERVHTDGRVFYIDHNTRTTQWEDPRLS 614
            |.:|.|.|.||   |...:.|:.        |||||||.|...||..:::|||.|||.:.|||..
Zfish   407 HPTRSTQWEDP---RTQGLLNEK--------PLPEGWEMRFTVDGIPYFVDHNRRTTTYIDPRTG 460

  Fly   615 NPNIA-GQAVPYSRDYKQKYEYFKSHIRKPTNVPNKFEIRIRRTSILEDSYRIISSVTKTDLLKT 678
            ..::. |..:.|.||:|.|..||:...:: .::|...:|.:.|.::.|||::.|......| |:.
Zfish   461 KSSLENGPQITYVRDFKAKVHYFRFWCQQ-LSMPQHIKIHVSRKTLFEDSFQQIMGCHPQD-LRR 523

  Fly   679 KLWVEFEGETGLDYGGLAREWFYLLSKEMFNPYYGLFEYSAMDNYTLQINNGSGLCNEEHLSYFK 743
            :||:.|.||.||||||:|||||:|||.|:.||.|.||||:..|||.||||..|.: |.:||.|||
Zfish   524 RLWIIFPGEEGLDYGGVAREWFFLLSHEVLNPMYCLFEYAGKDNYCLQINPASSI-NPDHLKYFK 587

  Fly   744 FIGRIAGMAVYHGKLLDAFFIRPFYKMMLQKPIDLKDMESVDTEYYNSLMWIKENDPRI--LELT 806
            ||||...||::|||.:|..|..||||.:|.||:.|||:||:|.|:||||:|||:|:...  ||:.
Zfish   588 FIGRFIAMALFHGKFIDTGFSLPFYKRILNKPLALKDLESIDPEFYNSLIWIKDNNIEECGLEMF 652

  Fly   807 FCLDEDVFGQKSQHELKPGGANIDVTNENKDEYIKLVIEWRFVARVKEQMSSFLDGFGSIIPLNL 871
            |.:|:::.|:.:.|||||.|.||.||.|||:|||:||.|||....|:||..:||:||..::|...
Zfish   653 FSVDKEILGEVTTHELKPDGGNIQVTEENKEEYIRLVAEWRLSRGVEEQTQAFLEGFNDVLPQQY 717

  Fly   872 IKIFDEHELELLMCGIQNIDVKDWRENTLYKGDYHMNHIIIQWFWRAVLSFSNEMRSRLLQFVTG 936
            ::.||..|||:::||:|.||:.||:.|::|: .|..:...|.|||:.|....||.|.||||||||
Zfish   718 LQYFDAKELEVMLCGMQEIDLGDWQRNSIYR-HYARSSKQIVWFWQFVKEMDNEKRMRLLQFVTG 781

  Fly   937 TSRVPMNGFKELYGSNGPQMFTIEKWGTPNNFPRAHTCFNRLDLPPYEGYLQLKDKLIKAIEGSQ 1001
            |.|:|:.||.:|.||||||.|.|||.|..|..||:||||||||||||:.|.|||:||:.|||.::
Zfish   782 TCRLPVGGFADLMGSNGPQKFCIEKVGKENWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETE 846

  Fly  1002 GF 1003
            ||
Zfish   847 GF 848

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Nedd4NP_648993.1 C2_NEDD4_NEDD4L 71..204 CDD:175999 43/201 (21%)
WW 248..277 CDD:278809 16/28 (57%)
WW 531..560 CDD:278809 10/28 (36%)
WW 581..613 CDD:197736 18/31 (58%)
HECTc 650..1003 CDD:238033 188/354 (53%)
HECTc 674..1003 CDD:214523 182/330 (55%)
itchaNP_001274024.1 C2_E3_ubiquitin_ligase 2..125 CDD:175988 35/131 (27%)
WW 276..305 CDD:278809 16/28 (57%)
WW 308..337 CDD:278809 10/110 (9%)
WW 387..418 CDD:197736 13/33 (39%)
WW 427..458 CDD:197736 17/30 (57%)
HECTc 496..849 CDD:238033 190/356 (53%)
HECTc 520..848 CDD:214523 182/330 (55%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000080
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100256
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
32.810

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