DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Nedd4 and itchb

DIOPT Version :9

Sequence 1:NP_648993.1 Gene:Nedd4 / 39958 FlyBaseID:FBgn0259174 Length:1007 Species:Drosophila melanogaster
Sequence 2:NP_001289155.1 Gene:itchb / 100330031 ZFINID:ZDB-GENE-131024-2 Length:867 Species:Danio rerio


Alignment Length:1059 Identity:338/1059 - (31%)
Similarity:467/1059 - (44%) Gaps:319/1059 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly    61 AAVNDSGDSCHLRIVVLTGQ-SLAKKDIFGASDPYVRIDLNTINGDINIDSVLTKTKK--KTLNP 122
            |..|.......|:|:|::.: ...||:.||.| |||         ::.:|....||:|  .|.:|
Zfish     9 APANGFPMKAQLQIMVISAKLKENKKNWFGPS-PYV---------EVCVDGQSKKTEKCNNTHSP 63

  Fly   123 TWNEEFIFRVKPSEHKLVFQVFDENRLTRDDFLGMVELTL-----------------VNLPTEQE 170
            .|.:.|:..|.|.. ||:|:|:....|..|..||:..|.:                 :.|....:
Zfish    64 KWKQSFVVIVTPFS-KLIFRVWSHQTLKSDLLLGVATLDISETLKSHDMKICEVVQTLQLCDRDQ 127

  Fly   171 GRTIGEQSYTL-----RPRRSVGAKSRIKGTLRIYHAFIRETREQSEPSSGNSDGEWEHVEATN- 229
            ..:||:.|..|     .|.....|::..:.||........::....:||...|:|: :...|.| 
Zfish   128 SDSIGDLSVCLDGLQVDPEMFQSAEASNQNTLNGESELNEDSGRSRDPSPSVSEGQ-DRPAAPNG 191

  Fly   230 -----------AGETSAQ--PHPF------------------------------------PTGGH 245
                       |..:.||  |.|.                                    ||||.
Zfish   192 RVNGLDSPSVSARSSRAQRPPRPSRPPPPTPRRPTSSPASSTGSFPDGSDSSRSDTPVRNPTGGG 256

  Fly   246 DA---------------------------------LPAGWEERQDANGRTYYVNHTARTTQWDRP 277
            .:                                 ||.|||:|.|.|||.|:|:|..:.|.|:||
Zfish   257 ASDSSPAPTVEQPGRTALSVGPTPSRIPSMVNAGPLPPGWEQRVDQNGRLYFVDHVEKRTTWERP 321

  Fly   278 TVLNSHSSQSTDDQLASDFQRRFHISVDDTESGRSADSISHNSIEDNNNAAGLAYTPKTAATSSA 342
                        :.|.|.::||    ||                     ..|..|          
Zfish   322 ------------EPLPSGWERR----VD---------------------PMGRVY---------- 339

  Fly   343 PPNTPTNNNGILAQIAMQYRAEEDQDPTVDHTSFVYNSLRHPVAHRQPEISATSLQNDLRPVREA 407
                                       .|||                                  
Zfish   340 ---------------------------FVDH---------------------------------- 343

  Fly   408 PGVPDIAITNPFTRRAAGNMAGGAGWQQERRRQQMQLHIQQHQQR-----QQQQQQNRILLDVDH 467
                 |..|..:.|.....:.....||.:  |.|:|..:||..||     |.|            
Zfish   344 -----ITRTTTWQRPTMETVRNYEQWQHQ--RSQLQGAMQQFNQRFIIGLQDQ------------ 389

  Fly   468 RQQEPQHRGQRHQQQHRPSNEDTDHTDSHNPSDISAPSTRRNSEEDNAAVPPMEQNTGGEEEPLP 532
                                                .|..:|.|.|     |:        .|||
Zfish   390 ------------------------------------ASATQNKEFD-----PL--------GPLP 405

  Fly   533 PRWSMQVAPNGRTFFIDHASRRTTWIDPRNGRASPMPNQTRRVEDDLGPLPEGWEERVHTDGRVF 597
            ..|..:...|||.:|:.|.:|.|.|.||   |...:.|:.        |||||||.|...||..:
Zfish   406 HGWEKRTDSNGRVYFVHHPTRSTQWEDP---RTQGLLNEK--------PLPEGWEMRFTVDGIPY 459

  Fly   598 YIDHNTRTTQWEDPRLSNPNIA-GQAVPYSRDYKQKYEYFKSHIRKPTNVPNKFEIRIRRTSILE 661
            ::|||.|||.:.|||....::. |..:.|.||:|.|.:||:...:: .::|...:|.:.|.::.|
Zfish   460 FVDHNRRTTTYIDPRTGKSSLENGPQITYVRDFKAKVQYFRFWCQQ-LSMPQHIKINVSRKTLFE 523

  Fly   662 DSYRIISSVTKTDLLKTKLWVEFEGETGLDYGGLAREWFYLLSKEMFNPYYGLFEYSAMDNYTLQ 726
            ||::.|.|.:..| |:.:||:.|.||.||||||:|||||:|||.|:.||.|.||||:..|||.||
Zfish   524 DSFQQIMSFSAQD-LRRRLWIIFPGEEGLDYGGVAREWFFLLSHEVLNPMYCLFEYAGKDNYCLQ 587

  Fly   727 INNGSGLCNEEHLSYFKFIGRIAGMAVYHGKLLDAFFIRPFYKMMLQKPIDLKDMESVDTEYYNS 791
            ||..|.: |.:||.|||||||...||::|||.:|..|..||||.:|.||:.|||:||:|.|:|||
Zfish   588 INPASYI-NPDHLKYFKFIGRFIAMALFHGKFIDTGFSLPFYKRILNKPLTLKDLESIDPEFYNS 651

  Fly   792 LMWIKENDPRI--LELTFCLDEDVFGQKSQHELKPGGANIDVTNENKDEYIKLVIEWRFVARVKE 854
            |:|||:|:...  ||:.|.:|:::.|:.|.|||||.|.||.||.|||:|||:||.|||....|:|
Zfish   652 LIWIKDNNIEECGLEMFFSVDKEILGEVSTHELKPDGGNIQVTEENKEEYIRLVAEWRLSRGVEE 716

  Fly   855 QMSSFLDGFGSIIPLNLIKIFDEHELELLMCGIQNIDVKDWRENTLYKGDYHMNHIIIQWFWRAV 919
            |..:|.:||..::|...::.||..|||:::||:|.||:.||:.||:|: .|..:...|.|||:.:
Zfish   717 QTQAFFEGFNEVLPQQYLQYFDAKELEVMLCGMQEIDLNDWQRNTIYR-HYTSSSKQIMWFWQFI 780

  Fly   920 LSFSNEMRSRLLQFVTGTSRVPMNGFKELYGSNGPQMFTIEKWGTPNNFPRAHTCFNRLDLPPYE 984
            ....||.|.|||||||||.|:|:.||.:|.||||||.|.|||.|..|..||:||||||||||||.
Zfish   781 KEMDNEKRMRLLQFVTGTCRLPVGGFADLMGSNGPQKFCIEKVGKENWLPRSHTCFNRLDLPPYR 845

  Fly   985 GYLQLKDKLIKAIEGSQGF 1003
            .|.|||:||:.|||.::||
Zfish   846 SYEQLKEKLMFAIEETEGF 864

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Nedd4NP_648993.1 C2_NEDD4_NEDD4L 71..204 CDD:175999 39/157 (25%)
WW 248..277 CDD:278809 15/28 (54%)
WW 531..560 CDD:278809 11/28 (39%)
WW 581..613 CDD:197736 18/31 (58%)
HECTc 650..1003 CDD:238033 189/354 (53%)
HECTc 674..1003 CDD:214523 182/330 (55%)
itchbNP_001289155.1 C2_E3_ubiquitin_ligase 17..139 CDD:175988 34/132 (26%)
WW 292..321 CDD:278809 15/28 (54%)
WW 324..353 CDD:278809 13/129 (10%)
WW 404..433 CDD:278809 11/28 (39%)
WW 443..474 CDD:197736 17/30 (57%)
HECTc 512..865 CDD:238033 191/356 (54%)
HECTc 536..864 CDD:214523 182/330 (55%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000080
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100256
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
32.810

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