Protein Alignment Nedd4 and hecw1

DIOPT Version :10

• Sequence 1: NP_648993.1
• Gene: Nedd4 / 39958
• FlyBaseID: FBgn0259174
• Length: 1007
• Species: Drosophila melanogaster
• Sequence 2: XP_017950053.1
• Gene: hecw1 / 100170498
• XenbaseID: XB-GENE-5969056
• Length: 1600
• Species: Xenopus tropicalis
• Alignment Length: 967
• Identity: 300/967 - (31%)
• Similarity: 428/967 - (44%)
• Gaps: 290/967 - (29%)

  Fly   206 ETREQSEPSSGNSDG--EWEH---------------VEATNAGETS------------------- 234
            ::.:..||....:||  :|..               :|:..||.::
 Frog   752 DSNQSPEPERDQADGSNQWSDDTSGQSVNSERTLGVLESPVAGPSNRTEGDCTLPNTTPSVTQLP 816

  Fly   235 ---AQPHPFPTGGHDALPAGWEERQDANGRTYYVNHTARTTQWDRPTVLNSHS--SQSTDDQLAS 294
               |..|.:|| ..:.||..||.|.|::||.:||:|..|||.|.|||...:..  |:|...|...
 Frog   817 SLRADHHHYPT-IDEPLPPNWEARIDSHGRVFYVDHVNRTTTWQRPTTAATPDGISRSGSIQQME 880

  Fly   295 DFQRRFH-----ISVDDTESGRSADSISHNSIEDNNNAAGLAYTPKTAATSSAPPNTPTNNNGIL 354
            ...||:.     |:.:.||         .:|:..|:.|.|:.    .:.|..:.|||.....|.|
 Frog   881 QLNRRYQNIQRTIATERTE---------EDSLGRNDRAPGVG----DSETDLSQPNTELRREGSL 932

  Fly   355 AQIAMQYRAEEDQDPTVDHTSFVYNSLRHPVAHRQPEISATSLQNDLRPVREAPGVPDIAITNP- 418
            ..|                     ||.:..:..:.|.:.                    .||||
 Frog   933 TPI---------------------NSQKITLLLQSPAVK--------------------FITNPE 956

  Fly   419 -FTRRAAGNMAGGAGWQQERRRQQMQLHIQQHQQRQQQQQQNRILLD-----VDHRQQEPQHRGQ 477
             ||...| |.:....:......:.|.|.|::..:..::.|.||.|::     .|.|.:
 Frog   957 FFTILHA-NYSAYRVFTNSTCLKHMVLKIRRDARNFERYQHNRDLVNFINMFADTRLE------- 1013

  Fly   478 RHQQQHRPSNEDTDHTDSHNPSDISAPSTRRNSEEDNAAVPPMEQNTGGEEEPLPPRWSMQVAPN 542
                                                                 ||..|.::....
 Frog  1014 -----------------------------------------------------LPRGWEIKTDQQ 1025

  Fly   543 GRTFFIDHASRRTTWIDPR----NGRASPMPN-----------------QTRRVEDDLG------ 580
            |::||:||.||.||:||||    |||   :||                 :...|..:.|
 Frog  1026 GKSFFVDHNSRATTFIDPRIPLQNGR---LPNHLTHRQHLQRLRSYSAGEASEVSRNRGASLLAR 1087

  Fly   581 ------------------PL------------PEGWE----------------ERVH---TDGR- 595
                              ||            |..:|                |::|   |:|.
 Frog  1088 PGHSLVTAVRNQHQHEAVPLAYNDKIVAFLRQPNIFEMLQERQPSLARNHALREKIHYIRTEGTH 1152

  Fly   596 ----------------------VFYI----------DHNTRTTQWEDPRLSNPNI----AGQAVP 624
                                  :.||          ..:.|.:....|: ::|.:    |....|
 Frog  1153 GLEKLSCDADLVILLSLFEEDIMSYIPLQAAFHPGYSFSPRCSPGSSPQ-NSPGLQRASARAPSP 1216

  Fly   625 YSRDYKQKYE--YFKSHIRKPTNVPNKFEIRIRRTSILEDSYRIISSVTKTDLLKTKLWVEFEGE 687
            |.||::.|..  |.|...:.....|.|.::.|||..:||.::..:.:.::.:|.:.||::.|.||
 Frog  1217 YRRDFEAKLRNFYRKLEAKGYGQGPGKIKLIIRRDHLLEGTFNQVMAYSRKELQRNKLYITFVGE 1281

  Fly   688 TGLDYGGLAREWFYLLSKEMFNPYYGLFEYSAMDNYTLQINNGSGLCNEEHLSYFKFIGRIAGMA 752
            .||||.|.:||:|:|||:|:||||||||||||.|.||:||:..|... |.||.:|:|.|||.|:|
 Frog  1282 EGLDYSGPSREFFFLLSQELFNPYYGLFEYSANDTYTVQISPMSAFV-ENHLEWFRFSGRILGLA 1345

  Fly   753 VYHGKLLDAFFIRPFYKMMLQKPIDLKDMESVDTEYYNSLMWIKEND-PRILELTFCLDEDVFGQ 816
            :.|..||||||.|||||.:|:.|.||.|:|.:|.|::.||.|:|:|| ..||:|||.::|:||||
 Frog  1346 LIHQYLLDAFFTRPFYKALLRLPCDLSDLEYLDEEFHQSLQWMKDNDITDILDLTFTVNEEVFGQ 1410

  Fly   817 KSQHELKPGGANIDVTNENKDEYIKLVIEWRFVARVKEQMSSFLDGFGSIIPLNLIKIFDEHELE 881
            .::.|||.|||||.|:.:||.|||:.:::||....|.:|..:.:.||..::...|:.:||..|||
 Frog  1411 VTERELKSGGANIQVSEKNKKEYIEKMVKWRVERGVVQQTEALVRGFYEVVDSRLVSVFDARELE 1475

  Fly   882 LLMCGIQNIDVKDWRENTLYKGDYHMNHIIIQWFWRAVLSFSNEMRSRLLQFVTGTSRVPMNGFK 946
            |::.|...||:.|||.||.|:|.||..||:|:|||.||..|:||.|.||||||||||.||..||.
 Frog  1476 LVIAGTAEIDLNDWRNNTEYRGGYHDGHIVIRWFWAAVERFNNEQRLRLLQFVTGTSSVPYEGFA 1540

  Fly   947 ELYGSNGPQMFTIEKWGTPNNFPRAHTCFNRLDLPPYEGYLQLKDKLIKAIEGSQGF 1003
            .|.||||.:.|.|||||...:.|||||||||||||||..|..|.:||:.|:|.:..|
 Frog  1541 ALRGSNGLRRFCIEKWGKITSLPRAHTCFNRLDLPPYPSYSMLHEKLLIAVEETSTF 1597

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nedd4	NP_648993.1	C2_NEDD4_NEDD4L	71..204	CDD:175999
		WW	248..277	CDD:459800	15/28 (54%)
		HUL4	<523..1003	CDD:227354	230/595 (39%)
hecw1	XP_017950053.1	HECW_N	67..184	CDD:465177
		C2_NEDL1-like	207..343	CDD:176073
		PRK08581	576..>791	CDD:236304	6/38 (16%)
		Keratin_B2_2	680..710	CDD:464017
		WW	832..861	CDD:459800	15/28 (54%)
		HECW1_helix	942..1008	CDD:465766	16/86 (19%)
		WW	1014..1045	CDD:197736	15/30 (50%)
		HECTc	1268..1597	CDD:214523	179/329 (54%)