DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nedd4 and hecw1

DIOPT Version :9

Sequence 1:	NP_648993.1	Gene:	Nedd4 / 39958	FlyBaseID:	FBgn0259174	Length:	1007	Species:	Drosophila melanogaster
Sequence 2:	XP_017950053.1	Gene:	hecw1 / 100170498	XenbaseID:	XB-GENE-5969056	Length:	1600	Species:	Xenopus tropicalis

Alignment Length:	967	Identity:	300/967 - (31%)
Similarity:	428/967 - (44%)	Gaps:	290/967 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   206 ETREQSEPSSGNSDG--EWEH---------------VEATNAGETS------------------- 234
            ::.:..||....:||  :|..               :|:..||.::
Frog   752 DSNQSPEPERDQADGSNQWSDDTSGQSVNSERTLGVLESPVAGPSNRTEGDCTLPNTTPSVTQLP 816

  Fly   235 ---AQPHPFPTGGHDALPAGWEERQDANGRTYYVNHTARTTQWDRPTVLNSHS--SQSTDDQLAS 294
               |..|.:|| ..:.||..||.|.|::||.:||:|..|||.|.|||...:..  |:|...|...
Frog   817 SLRADHHHYPT-IDEPLPPNWEARIDSHGRVFYVDHVNRTTTWQRPTTAATPDGISRSGSIQQME 880

  Fly   295 DFQRRFH-----ISVDDTESGRSADSISHNSIEDNNNAAGLAYTPKTAATSSAPPNTPTNNNGIL 354
            ...||:.     |:.:.||         .:|:..|:.|.|:.    .:.|..:.|||.....|.|
Frog   881 QLNRRYQNIQRTIATERTE---------EDSLGRNDRAPGVG----DSETDLSQPNTELRREGSL 932

  Fly   355 AQIAMQYRAEEDQDPTVDHTSFVYNSLRHPVAHRQPEISATSLQNDLRPVREAPGVPDIAITNP- 418
            ..|                     ||.:..:..:.|.:.                    .||||
Frog   933 TPI---------------------NSQKITLLLQSPAVK--------------------FITNPE 956

  Fly   419 -FTRRAAGNMAGGAGWQQERRRQQMQLHIQQHQQRQQQQQQNRILLD-----VDHRQQEPQHRGQ 477
             ||...| |.:....:......:.|.|.|::..:..::.|.||.|::     .|.|.:
Frog   957 FFTILHA-NYSAYRVFTNSTCLKHMVLKIRRDARNFERYQHNRDLVNFINMFADTRLE------- 1013

  Fly   478 RHQQQHRPSNEDTDHTDSHNPSDISAPSTRRNSEEDNAAVPPMEQNTGGEEEPLPPRWSMQVAPN 542
                                                                 ||..|.::....
Frog  1014 -----------------------------------------------------LPRGWEIKTDQQ 1025

  Fly   543 GRTFFIDHASRRTTWIDPR----NGRASPMPN-----------------QTRRVEDDLG------ 580
            |::||:||.||.||:||||    |||   :||                 :...|..:.|
Frog  1026 GKSFFVDHNSRATTFIDPRIPLQNGR---LPNHLTHRQHLQRLRSYSAGEASEVSRNRGASLLAR 1087

  Fly   581 ------------------PL------------PEGWE----------------ERVH---TDGR- 595
                              ||            |..:|                |::|   |:|.
Frog  1088 PGHSLVTAVRNQHQHEAVPLAYNDKIVAFLRQPNIFEMLQERQPSLARNHALREKIHYIRTEGTH 1152

  Fly   596 ----------------------VFYI----------DHNTRTTQWEDPRLSNPNI----AGQAVP 624
                                  :.||          ..:.|.:....|: ::|.:    |....|
Frog  1153 GLEKLSCDADLVILLSLFEEDIMSYIPLQAAFHPGYSFSPRCSPGSSPQ-NSPGLQRASARAPSP 1216

  Fly   625 YSRDYKQKYE--YFKSHIRKPTNVPNKFEIRIRRTSILEDSYRIISSVTKTDLLKTKLWVEFEGE 687
            |.||::.|..  |.|...:.....|.|.::.|||..:||.::..:.:.::.:|.:.||::.|.||
Frog  1217 YRRDFEAKLRNFYRKLEAKGYGQGPGKIKLIIRRDHLLEGTFNQVMAYSRKELQRNKLYITFVGE 1281

  Fly   688 TGLDYGGLAREWFYLLSKEMFNPYYGLFEYSAMDNYTLQINNGSGLCNEEHLSYFKFIGRIAGMA 752
            .||||.|.:||:|:|||:|:||||||||||||.|.||:||:..|... |.||.:|:|.|||.|:|
Frog  1282 EGLDYSGPSREFFFLLSQELFNPYYGLFEYSANDTYTVQISPMSAFV-ENHLEWFRFSGRILGLA 1345

  Fly   753 VYHGKLLDAFFIRPFYKMMLQKPIDLKDMESVDTEYYNSLMWIKEND-PRILELTFCLDEDVFGQ 816
            :.|..||||||.|||||.:|:.|.||.|:|.:|.|::.||.|:|:|| ..||:|||.::|:||||
Frog  1346 LIHQYLLDAFFTRPFYKALLRLPCDLSDLEYLDEEFHQSLQWMKDNDITDILDLTFTVNEEVFGQ 1410

  Fly   817 KSQHELKPGGANIDVTNENKDEYIKLVIEWRFVARVKEQMSSFLDGFGSIIPLNLIKIFDEHELE 881
            .::.|||.|||||.|:.:||.|||:.:::||....|.:|..:.:.||..::...|:.:||..|||
Frog  1411 VTERELKSGGANIQVSEKNKKEYIEKMVKWRVERGVVQQTEALVRGFYEVVDSRLVSVFDARELE 1475

  Fly   882 LLMCGIQNIDVKDWRENTLYKGDYHMNHIIIQWFWRAVLSFSNEMRSRLLQFVTGTSRVPMNGFK 946
            |::.|...||:.|||.||.|:|.||..||:|:|||.||..|:||.|.||||||||||.||..||.
Frog  1476 LVIAGTAEIDLNDWRNNTEYRGGYHDGHIVIRWFWAAVERFNNEQRLRLLQFVTGTSSVPYEGFA 1540

  Fly   947 ELYGSNGPQMFTIEKWGTPNNFPRAHTCFNRLDLPPYEGYLQLKDKLIKAIEGSQGF 1003
            .|.||||.:.|.|||||...:.|||||||||||||||..|..|.:||:.|:|.:..|
Frog  1541 ALRGSNGLRRFCIEKWGKITSLPRAHTCFNRLDLPPYPSYSMLHEKLLIAVEETSTF 1597

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nedd4	NP_648993.1	C2_NEDD4_NEDD4L	71..204	CDD:175999
		WW	248..277	CDD:278809	15/28 (54%)
		WW	531..560	CDD:278809	13/28 (46%)
		WW	581..613	CDD:197736	12/95 (13%)
		HECTc	650..1003	CDD:238033	184/353 (52%)
		HECTc	674..1003	CDD:214523	179/329 (54%)
hecw1	XP_017950053.1	HECW_N	67..186	CDD:374632
		C2_NEDL1-like	207..343	CDD:176073
		MSCRAMM_SdrC	<588..786	CDD:380146	5/33 (15%)
		WW	832..861	CDD:366073	15/28 (54%)
		HECW1_helix	942..1008	CDD:375862	16/86 (19%)
		WW	1014..1045	CDD:197736	15/30 (50%)
		HECTc	1268..1597	CDD:214523	179/329 (54%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000080
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000