DRSC/TRiP Functional Genomics Resources

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Protein Alignment Nedd4 and hecw2a

DIOPT Version :9

Sequence 1:NP_648993.1 Gene:Nedd4 / 39958 FlyBaseID:FBgn0259174 Length:1007 Species:Drosophila melanogaster
Sequence 2:XP_009302976.1 Gene:hecw2a / 100150269 ZFINID:ZDB-GENE-090311-22 Length:1475 Species:Danio rerio


Alignment Length:1367 Identity:353/1367 - (25%)
Similarity:524/1367 - (38%) Gaps:457/1367 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly    33 PRRRAASVAGQQQTRQEFGNGYTPRRSLAAVNDSGDSCHLRIVVLTGQSLAKKDIFGASDPYVRI 97
            ||   |||.||.:.:|...:.    |.|.:...|    .:|.|.|      ||.:|...|||:::
Zfish   167 PR---ASVDGQGEGQQASDSS----RKLVSFTLS----DIRAVGL------KKGMFFNPDPYLKM 214

  Fly    98 DLN----------TINGDINIDSVLTKTKKKTLNPTWNEEFIFRVKPSEHKLVFQV---FDENRL 149
            .::          :.:|......:.|    .|.||.|:.|....|......||.:|   |.::|.
Zfish   215 SIHPGKRSCFPTFSHHGQERRSGITT----NTTNPVWHGEKHTFVALMTDVLVIEVKDKFAKSRP 275

  Fly   150 TRDDFLGMVELTLVNLPTE--QEGRTIGEQSYTLR-----PRRSVGAKSRIKGTLRIY------- 200
            ....|||.     :|:|.:  .|..:.|.||.:..     |...|..:...|..:...       
Zfish   276 IIKRFLGQ-----LNIPVQLLLERHSTGNQSLSFSLCRRLPTDHVSGQMHFKVDVTSMGPDDVSP 335

  Fly   201 HAFIRETREQSEPSSGNSDGEWEH--------------VEATNAGETSAQPHPFPT--GG----- 244
            ...:........|.:.:.|.|..|              :.:...||.|:.|.|...  ||     
Zfish   336 ETILGAAALNGAPGTPSDDEELPHPLPISSAGPSPTASLGSNRNGEGSSIPSPDTEIYGGTLDDE 400

  Fly   245 ----HDALPAGWEERQDANGRTYYVNHTARTTQWDRPTVLNS---HSSQSTDDQLASDFQRRFHI 302
                .|.|...:.|:.||        ..|.....|||....|   .||..|..:|::    ..||
Zfish   401 APSSPDLLQGSFSEQLDA--------IEAPKGPGDRPLGAASPKLRSSFPTHTRLSA----MLHI 453

  Fly   303 SVDDTESGRSA-------------------------DSISHNSIEDNNNAAGLAYTPKTA-ATSS 341
            ..|:.|. |||                         .::....||:.:..|||....:|. |...
Zfish   454 DSDEDED-RSAATEATLSTFNGIPRSYQTPPKAAARGAVFDGGIEEPSEEAGLESEVETLNAGEE 517

  Fly   342 APPNTPTNNNGILAQI--AMQYRAEEDQDPTVDHTSFVYNSLRHPVAHRQ---PEISATSLQNDL 401
            .||......:.:..::  |.....:|:|...|:    |.......:|..:   .|:..:|:.:|.
Zfish   518 VPPEPEVVPSSVAPEVETASLMERQEEQGREVE----VEEEEEEGLARSEELATEVDISSMASDC 578

  Fly   402 RP-----VREA---------PGVPDIAITNPFTRRAAGNMAGGAGWQQERRRQQMQLHIQQHQQR 452
            .|     .:||         ||..|::...|.|...|              ....:.|:....:|
Zfish   579 CPGPASASQEAEQGAEAAIDPGGEDLSDDPPTTYEVA--------------ETAEETHLTNEPER 629

  Fly   453 Q---------QQQQQNRILLDVDHRQ---QEPQHRGQRHQQQHRPSNE----DTDHTDSHNPSDI 501
            :         ::::...:..|...|:   :......|..:.:..||.:    |::...:...|::
Zfish   630 EAPKPEPPTNEEEECEDVTEDTMSRRWSLEATAGVSQEDEDELIPSGDGESVDSETFVTETESEL 694

  Fly   502 SAPSTRRNSEEDNAAVPPMEQNT---GGEEEPLPPRWSMQVAPNGRTFFIDHASRRTTWIDPRNG 563
            ..|..  |.::...::|.:.|:.   ...:|||||.|..::..:||.||:||.:|.|||..| .|
Zfish   695 GVPQV--NGDQRVNSLPSVRQDIHRYQRVDEPLPPNWEARIDSHGRIFFVDHVNRTTTWQRP-TG 756

  Fly   564 RASPM----------------------------PNQTRRVED----------------------- 577
            ..:|.                            .::..||||                       
Zfish   757 PPAPQGLTRSSSILQMEQLNRRYQSIRRTMTSERSEEPRVEDPPADETDVLAQSISEYRRDGIIG 821

  Fly   578 ----------------------------------------------------------------- 577
                                                                             
Zfish   822 QSSSRSRLALLLQSPGAKFLSSPDFFSVLHSNPSAYRMFTSNTCLKHMISKVRRDAQHFERYQHN 886

  Fly   578 -DLG-----------PLPEGWEERVHTDGRVFYIDHNTRTTQWEDPR------------------ 612
             ||.           .||.|||.:....|:.|::|||.|.|.:.|||                  
Zfish   887 RDLVNFLNLFSNKQLELPRGWEMKHDHTGKAFFVDHNCRATTFIDPRLPLQNSRSSGLLAHRQHL 951

  Fly   613 -----------------------------------------------LSNPNI------------ 618
                                                           |..|||            
Zfish   952 SRQRSHSAGEVGDDSRSPSPPVQGRSSRNSQYQDLVPVAYNDKIVAFLRQPNIFEILQERQPELV 1016

  Fly   619 ----------------------------------------------------------------- 618
                                                                             
Zfish  1017 RNHSLREKVQFIRNEGATGLTRLSSDADLVMLLSLFEEEVMSYVPPNALLLSSYCHASPQSSPGT 1081

  Fly   619 ----AGQAVPYSRDYKQKYE--YFKSHIRKPTNVPNKFEIRIRRTSILEDSYRIISSVTKTDLLK 677
                |....||.||::.|..  |.|...:.....|.|.::.|||..:|||::..|...::.||.:
Zfish  1082 PRANARAPAPYKRDFEAKLRNFYRKMETKGYGQGPGKVKLIIRRDHLLEDAFNQIMCYSRKDLQR 1146

  Fly   678 TKLWVEFEGETGLDYGGLAREWFYLLSKEMFNPYYGLFEYSAMDNYTLQINNGSGLCNEEHLSYF 742
            ::|:|.|.||.||||.|.:||:|:|:|:|:||||||||||||.|.||:||:..|...:..| .:|
Zfish  1147 SRLYVSFVGEEGLDYSGPSREFFFLVSRELFNPYYGLFEYSANDTYTVQISPMSAFVDNHH-EWF 1210

  Fly   743 KFIGRIAGMAVYHGKLLDAFFIRPFYKMMLQKPIDLKDMESVDTEYYNSLMWIKEND-PRILELT 806
            :|.|||.|:|:.|..||||||.|||||.:|:.|.||.|:|.:|.|::.||.|:|:|| ..:|:||
Zfish  1211 RFSGRILGLALIHQYLLDAFFTRPFYKGLLRIPCDLSDLEFLDEEFHQSLQWMKDNDIEDMLDLT 1275

  Fly   807 FCLDEDVFGQKSQHELKPGGANIDVTNENKDEYIKLVIEWRFVARVKEQMSSFLDGFGSIIPLNL 871
            |.::|:||||.::.||||||:.|.|:::||.|||:.:::||....|.:|..|.:.||..::.:.|
Zfish  1276 FTVNEEVFGQITERELKPGGSGIAVSDKNKKEYIERMVKWRIERGVAQQTESLVRGFYEVVDVRL 1340

  Fly   872 IKIFDEHELELLMCGIQNIDVKDWRENTLYKGDYHMNHIIIQWFWRAVLSFSNEMRSRLLQFVTG 936
            :.:||..||||::.|...||:.|||.||.|:|.||.|||:|:|||.||..|:||.|.||||||||
Zfish  1341 VSVFDARELELVIAGTAEIDLSDWRNNTEYRGGYHDNHIVIRWFWAAVERFNNEQRLRLLQFVTG 1405

  Fly   937 TSRVPMNGFKELYGSNGPQMFTIEKWGTPNNFPRAHTCFNRLDLPPYEGYLQLKDKLIKAIEGSQ 1001
            ||.:|..||..|.|||||:.|.:||||...:.|||||||||||||||..:..|.:|::.|:|.:.
Zfish  1406 TSSIPYEGFASLRGSNGPRRFCVEKWGKVTSLPRAHTCFNRLDLPPYPSFSMLYEKMVTAVEETS 1470

  Fly  1002 GF 1003
            .|
Zfish  1471 TF 1472

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Nedd4NP_648993.1 C2_NEDD4_NEDD4L 71..204 CDD:175999 34/159 (21%)
WW 248..277 CDD:278809 6/28 (21%)
WW 531..560 CDD:278809 14/28 (50%)
WW 581..613 CDD:197736 15/96 (16%)
HECTc 650..1003 CDD:238033 181/353 (51%)
HECTc 674..1003 CDD:214523 174/329 (53%)
hecw2aXP_009302976.1 HECW_N 50..169 CDD:318711 2/4 (50%)
C2_NEDL1-like 188..323 CDD:176073 34/153 (22%)
WW 724..756 CDD:197736 16/32 (50%)
WW 903..934 CDD:197736 14/30 (47%)
HECTc 1120..1473 CDD:238033 182/354 (51%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000080
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
43.810

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