Protein Alignment Nedd4 and hecw2a

DIOPT Version :10

• Sequence 1: NP_648993.1
• Gene: Nedd4 / 39958
• FlyBaseID: FBgn0259174
• Length: 1007
• Species: Drosophila melanogaster
• Sequence 2: XP_021334623.2
• Gene: hecw2a / 100150269
• ZFINID: ZDB-GENE-090311-22
• Length: 1475
• Species: Danio rerio
• Alignment Length: 1367
• Identity: 352/1367 - (25%)
• Similarity: 524/1367 - (38%)
• Gaps: 457/1367 - (33%)

  Fly    33 PRRRAASVAGQQQTRQEFGNGYTPRRSLAAVNDSGDSCHLRIVVLTGQSLAKKDIFGASDPYVRI 97
            ||   |||.||.:.:|...:.    |.|.:...|    .:|.|.|      ||.:|...|||:::
Zfish   167 PR---ASVDGQGEGQQASDSS----RKLVSFTLS----DIRAVGL------KKGMFFNPDPYLKM 214

  Fly    98 DLN----------TINGDINIDSVLTKTKKKTLNPTWNEEFIFRVKPSEHKLVFQV---FDENRL 149
            .::          :.:|......:.|    .|.||.|:.|....|......||.:|   |.::|.
Zfish   215 SIHPGKRSCFPTFSHHGQERRSGITT----NTTNPVWHGEKHTFVALMTDVLVIEVKDKFAKSRP 275

  Fly   150 TRDDFLGMVELTLVNLPTE--QEGRTIGEQSYTLR-----PRRSVGAKSRIKGTLRIY------- 200
            ....|||.     :|:|.:  .|..:.|.||.:..     |...|..:...|..:...
Zfish   276 IIKRFLGQ-----LNIPVQLLLERHSTGNQSLSFSLCRRLPTDHVSGQMHFKVDVTSMGPDDVSP 335

  Fly   201 HAFIRETREQSEPSSGNSDGEWEH--------------VEATNAGETSAQPHPFPT--GG----- 244
            ...:........|.:.:.|.|..|              :.:...||.|:.|.|...  ||
Zfish   336 ETILGAAALNGAPGTPSDDEELPHPLPISSAGPSPTASLGSNRNGEGSSIPSPDTEIYGGTLDDE 400

  Fly   245 ----HDALPAGWEERQDANGRTYYVNHTARTTQWDRPTVLNS---HSSQSTDDQLASDFQRRFHI 302
                .|.|...:.|:.||        ..|.....|||....|   .||..|..:|::    ..||
Zfish   401 APSSPDLLQGSFSEQLDA--------IEAPKGPGDRPLGAASPKLRSSFPTHTRLSA----MLHI 453

  Fly   303 SVDDTESGRSA-------------------------DSISHNSIEDNNNAAGLAYTPKTA-ATSS 341
            ..|:.|. |||                         .::....:|:.:..|||....:|. |...
Zfish   454 DSDEDED-RSAATEATLSTFNGIPRSYQTPPKAAARGAVFDGGVEEPSEEAGLESEVETLNAGEE 517

  Fly   342 APPNTPTNNNGILAQI--AMQYRAEEDQDPTVDHTSFVYNSLRHPVAHRQ---PEISATSLQNDL 401
            .||......:.:..::  |.....:|:|...|:    |.......:|..:   .|:..:|:.:|.
Zfish   518 VPPEPEVVPSSVAPEVETASLMERQEEQGREVE----VEEEEEEGLARSEELATEVDISSMASDC 578

  Fly   402 RP-----VREA---------PGVPDIAITNPFTRRAAGNMAGGAGWQQERRRQQMQLHIQQHQQR 452
            .|     .:||         ||..|::...|.|...|              ....:.|:....:|
Zfish   579 CPGPASASQEAEQGAEAAIDPGGEDLSDDPPTTYEVA--------------ETAEETHLTNEPER 629

  Fly   453 Q---------QQQQQNRILLDVDHRQ---QEPQHRGQRHQQQHRPSNE----DTDHTDSHNPSDI 501
            :         ::::...:..|...|:   :......|..:.:..||.:    |::...:...|::
Zfish   630 EAPKPEPPTNEEEECEDVTEDTMSRRWSLEATAGVSQEDEDELIPSGDGESVDSETFVTETESEL 694

  Fly   502 SAPSTRRNSEEDNAAVPPMEQNT---GGEEEPLPPRWSMQVAPNGRTFFIDHASRRTTWIDPRNG 563
            ..|..  |.::...::|.:.|:.   ...:|||||.|..::..:||.||:||.:|.|||..| .|
Zfish   695 GVPQV--NGDQRVNSLPSVRQDIHRYQRVDEPLPPNWEARIDSHGRIFFVDHVNRTTTWQRP-TG 756

  Fly   564 RASPM----------------------------PNQTRRVED----------------------- 577
            ..:|.                            .::..||||
Zfish   757 PPAPQGLTRSSSILQMEQLNRRYQSIRRTMTSERSEEPRVEDPPADETDVLAQSISEYRRDGIIG 821

  Fly   578 ----------------------------------------------------------------- 577
                                                                             
Zfish   822 QASSRSRLALLLQSPGAKFLSSPDFFSVLHSNPSAYRMFTSNTCLKHMISKVRRDAQHFERYQHN 886

  Fly   578 -DLG-----------PLPEGWEERVHTDGRVFYIDHNTRTTQWEDPR------------------ 612
             ||.           .||.|||.:....|:.|::|||.|.|.:.|||
Zfish   887 RDLVNFLNLFSNKQLELPRGWEMKHDHTGKAFFVDHNCRATTFIDPRLPLQNSRSSGLLAHRQHL 951

  Fly   613 -----------------------------------------------LSNPNI------------ 618
                                                           |..|||
Zfish   952 SRQRSHSAGEVGDDSRSPSPPVQGRSSRNSQYQDLVPVAYNDKIVAFLRQPNIFEILQERQPELV 1016

  Fly   619 ----------------------------------------------------------------- 618
                                                                             
Zfish  1017 RNHSLREKVQFIRNEGATGLTRLSSDADLVMLLSLFEEEVMSYVPPNALLLSSYCHASPQSSPGT 1081

  Fly   619 ----AGQAVPYSRDYKQKYE--YFKSHIRKPTNVPNKFEIRIRRTSILEDSYRIISSVTKTDLLK 677
                |....||.||::.|..  |.|...:.....|.|.::.|||..:|||::..|...::.||.:
Zfish  1082 PRANARAPAPYKRDFEAKLRNFYRKMETKGYGQGPGKVKLIIRRDHLLEDAFNQIMCYSRKDLQR 1146

  Fly   678 TKLWVEFEGETGLDYGGLAREWFYLLSKEMFNPYYGLFEYSAMDNYTLQINNGSGLCNEEHLSYF 742
            ::|:|.|.||.||||.|.:||:|:|:|:|:||||||||||||.|.||:||:..|...:..| .:|
Zfish  1147 SRLYVSFVGEEGLDYSGPSREFFFLVSRELFNPYYGLFEYSANDTYTVQISPMSAFVDNHH-EWF 1210

  Fly   743 KFIGRIAGMAVYHGKLLDAFFIRPFYKMMLQKPIDLKDMESVDTEYYNSLMWIKEND-PRILELT 806
            :|.|||.|:|:.|..||||||.|||||.:|:.|.||.|:|.:|.|::.||.|:|:|| ..:|:||
Zfish  1211 RFSGRILGLALIHQYLLDAFFTRPFYKGLLRIPCDLSDLEFLDEEFHQSLQWMKDNDIEDMLDLT 1275

  Fly   807 FCLDEDVFGQKSQHELKPGGANIDVTNENKDEYIKLVIEWRFVARVKEQMSSFLDGFGSIIPLNL 871
            |.::|:||||.::.||||||:.|.|:::||.|||:.:::||....|.:|..|.:.||..::.:.|
Zfish  1276 FTVNEEVFGQITERELKPGGSGIAVSDKNKKEYIERMVKWRIERGVAQQTESLVRGFYEVVDVRL 1340

  Fly   872 IKIFDEHELELLMCGIQNIDVKDWRENTLYKGDYHMNHIIIQWFWRAVLSFSNEMRSRLLQFVTG 936
            :.:||..||||::.|...||:.|||.||.|:|.||.|||:|:|||.||..|:||.|.||||||||
Zfish  1341 VSVFDARELELVIAGTAEIDLSDWRNNTEYRGGYHDNHIVIRWFWAAVERFNNEQRLRLLQFVTG 1405

  Fly   937 TSRVPMNGFKELYGSNGPQMFTIEKWGTPNNFPRAHTCFNRLDLPPYEGYLQLKDKLIKAIEGSQ 1001
            ||.:|..||..|.|||||:.|.:||||...:.|||||||||||||||..:..|.:|::.|:|.:.
Zfish  1406 TSSIPYEGFASLRGSNGPRRFCVEKWGKVTSLPRAHTCFNRLDLPPYPSFSMLYEKMVTAVEETS 1470

  Fly  1002 GF 1003
            .|
Zfish  1471 TF 1472

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nedd4	NP_648993.1	C2_NEDD4_NEDD4L	71..204	CDD:175999	34/159 (21%)
		WW	248..277	CDD:459800	6/28 (21%)
		HUL4	<523..1003	CDD:227354	235/759 (31%)
hecw2a	XP_021334623.2	None