DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nedd4 and herc5.4

DIOPT Version :9

Sequence 1:	NP_648993.1	Gene:	Nedd4 / 39958	FlyBaseID:	FBgn0259174	Length:	1007	Species:	Drosophila melanogaster
Sequence 2:	XP_005160166.1	Gene:	herc5.4 / 100148091	ZFINID:	ZDB-GENE-090311-7	Length:	995	Species:	Danio rerio

Alignment Length:	405	Identity:	118/405 - (29%)
Similarity:	184/405 - (45%)	Gaps:	59/405 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   624 PYSRDY--KQKY------EYFKSHIRKPTNVP-----NKFE--IRIRRTSILEDSYRIISSVTKT 673
            |::.|:  ||:.      |.|:       |||     |.|.  :.|.|.|:|.|:.:.:..  .|
Zfish   622 PFASDFITKQRMFNLLQEECFR-------NVPNLAMGNSFSNLLHINRESVLTDTLQYLRQ--NT 677

  Fly   674 DLLKTKLWVEFEGETGLDYGGLAREWFYLLSKEMFNPYYGLFEYSAMDNYTLQINNGSGL-CNEE 737
            ......|.|.|.||.|:|..||:.|:|.|:||          .:...|...|:::..|.: .|..
Zfish   678 HSFMHPLQVAFIGEDGIDMRGLSAEFFSLISK----------SFIEWDKKILEVHESSLVWFNPH 732

  Fly   738 HL---SYFKFIGRIAGMAVYHGKLLDAFF-IRPFYKMMLQKPI--DLKDMESVDTEYYNSLMWIK 796
            |.   ..|.::|.|.|||:|:...::..| :..|.|::.|||.  ||:::..|:.....:|  ::
Zfish   733 HTRGNKNFYYLGVICGMALYNRHHINIDFPLALFKKLLQQKPSLDDLEELSPVEARSLKNL--LE 795

  Fly   797 ENDPRILELTFCLDEDVFGQKSQHELKPGGANIDVTNENKDEYIKLVIEWRFVARVKEQMSSFLD 861
            |::..::.|.. ||....||    ||.|.|:.|.|...|:.:|:.|.::..|...||.|...|..
Zfish   796 EDEEEVVNLQH-LDFTCKGQ----ELVPNGSQIQVNKVNRQKYVDLYVDLEFNKSVKTQFEQFTR 855

  Fly   862 GFGSIIPLNLIKIFDEHELELLMCGIQNIDVKDWRENTLYKGDYHMNHIIIQWFWRAVLSFSNEM 926
            ||....||:...:|...||:.|:.|....:.|:.:::..|:| ...:..:|:.||......|.|.
Zfish   856 GFSKGCPLDAWTMFHPEELQELLHGSPQYNWKELQQSASYEG-CSASDELIKNFWTVFFELSEEN 919

  Fly   927 RSRLLQFVTGTSRVPMNGFKELYGSNGPQMFTIEKWGTP---NNFPRAHTCFNRLDLPPYEGYLQ 988
            :.:.|.|:.||.|||..|..:       :...|.:...|   ::.|.|.|||.||.||.|.....
Zfish   920 KKKFLMFLYGTERVPAGGLSK-------RALKISQTDCPDPDDHLPEAQTCFERLVLPKYSDINT 977

  Fly   989 LKDKLIKAIEGSQGF 1003
            |.||||.||.....|
Zfish   978 LHDKLIHAINSCAVF 992

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nedd4	NP_648993.1	C2_NEDD4_NEDD4L	71..204	CDD:175999
		WW	248..277	CDD:278809
		WW	531..560	CDD:278809
		WW	581..613	CDD:197736
		HECTc	650..1003	CDD:238033	107/364 (29%)
		HECTc	674..1003	CDD:214523	100/338 (30%)
herc5.4	XP_005160166.1	RCC1_2	117..146	CDD:290274
		RCC1	133..183	CDD:278826
		RCC1	186..235	CDD:278826
		RCC1	239..286	CDD:278826
		RCC1	294..343	CDD:278826
		HECTc	658..993	CDD:294058	107/362 (30%)
		HECTc	682..992	CDD:214523	100/334 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810