DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nedd4 and herc5.3

DIOPT Version :9

Sequence 1:	NP_648993.1	Gene:	Nedd4 / 39958	FlyBaseID:	FBgn0259174	Length:	1007	Species:	Drosophila melanogaster
Sequence 2:	XP_021330683.1	Gene:	herc5.3 / 100073325	ZFINID:	ZDB-GENE-070615-14	Length:	1002	Species:	Danio rerio

Alignment Length:	363	Identity:	101/363 - (27%)
Similarity:	173/363 - (47%)	Gaps:	39/363 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   652 IRIRRTSILEDSYRIISSVTKTDLLKTKLWVEFEGETGLDYGGLAREWFYLLSKEMFNPYYGLFE 716
            :.|.|.|:|.|:.:.:...|.:  ....|.|.|.||..:|...::.|:|.|:||          .
Zfish   665 LHINRESVLTDTLQYLRPFTYS--FMHPLQVAFIGEDEIDEKVISAEFFSLISK----------S 717

  Fly   717 YSAMDNYTLQINNGSGLC-----NEEHLSYFKFIGRIAGMAVYHGKLLDAFF-IRPFYKMMLQKP 775
            :...|...|:::..|.:.     .::|..:: ::|.|.|||:|:...::..| :..|.|::.|||
Zfish   718 FIEWDKKILEVHESSLVWFNPHHTQDHRDFY-YLGVICGMALYNRHHINIDFPLALFKKLLQQKP 781

  Fly   776 I--DLKDMESVDTEYYNSLMWIKENDPRILELTFCLDEDVFGQKSQHELKPGGANIDVTNENKDE 838
            .  ||:::..|:.....:|  ::|::..:::|.. ||....||    ||.|.|:.|.|...|:.:
Zfish   782 SLDDLEELSPVEARSLKNL--LEEDEEEVVDLQH-LDFTCKGQ----ELVPNGSQIQVNKVNRQK 839

  Fly   839 YIKLVIEWRFVARVKEQMSSFLDGFGSIIPLNLIKIFDEHELELLMCGIQNIDVKDWRENTLYKG 903
            |:.|.:::.|...||.|...|.:||....||:...:|...||:.|:.|....:..:.:::..|:|
Zfish   840 YVDLYVDFVFNKSVKTQFEQFTEGFSEGCPLDAWTMFHPEELQELLHGSPQYNWNELQQSASYEG 904

  Fly   904 DYHMNHIIIQWFWRAVLSFSNEMRSRLLQFVTGTSRVPMNGFKELYGSNGPQMFTIEKWGTP--- 965
             ...:..:|:.||......|.|.:.:.|.|:.||.|||..||.:       :...|.:...|
Zfish   905 -CSASDELIKNFWTVFFELSEENKKKFLMFLYGTERVPAGGFSK-------RALKISQTDCPDPD 961

  Fly   966 NNFPRAHTCFNRLDLPPYEGYLQLKDKLIKAIEGSQGF 1003
            ::.|.|.|||.||.||.|.....|:||||.|:.....|
Zfish   962 DHLPEAQTCFERLVLPKYSDINTLRDKLIHAVNSCAVF 999

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nedd4	NP_648993.1	C2_NEDD4_NEDD4L	71..204	CDD:175999
		WW	248..277	CDD:278809
		WW	531..560	CDD:278809
		WW	581..613	CDD:197736
		HECTc	650..1003	CDD:238033	100/361 (28%)
		HECTc	674..1003	CDD:214523	94/339 (28%)
herc5.3	XP_021330683.1	RCC1	<74..349	CDD:332518
herc5.3	XP_021330683.1	HECTc	665..1000	CDD:331829	101/363 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910