Protein Alignment Nedd4 and wwp2

DIOPT Version :9

• Sequence 1: NP_648993.1
• Gene: Nedd4 / 39958
• FlyBaseID: FBgn0259174
• Length: 1007
• Species: Drosophila melanogaster
• Sequence 2: NP_001090841.1
• Gene: wwp2 / 100038252
• XenbaseID: XB-GENE-961516
• Length: 729
• Species: Xenopus tropicalis
• Alignment Length: 593
• Identity: 253/593 - (42%)
• Similarity: 345/593 - (58%)
• Gaps: 81/593 - (13%)

  Fly   487 NEDTDHTDSHNPSDIS-----APSTRRNSEEDNAAVPPMEQNTGGE--EEPLPPRWSMQVAPNGR 544
            :||.:.|.|..||.::     .|......|..|..|..::.||...  |.|||..|..:|...||
 Frog   139 SEDNEDTQSLQPSALTPTSEGLPPGWEQRELSNGRVYYVDHNTKSTTWERPLPLGWEKRVDNRGR 203

  Fly   545 TFFIDHASRRTTWIDP--------------RNGRASPMPNQTRRV----------EDDLGPLPEG 585
            .:::||.:|.|||..|              ||.....|...::|.          .|.|||||.|
 Frog   204 FYYVDHNTRTTTWQRPTAEYVRNYEQWQSQRNQMQGAMQQLSQRFLYQPSSAAPDNDPLGPLPNG 268

  Fly   586 WEERVHTDGRVFYIDHNTRTTQWEDPR----LSNPNI---------------------------- 618
            ||:| ..:|||:|::||||||||||||    :..|.:
 Frog   269 WEKR-QDNGRVYYVNHNTRTTQWEDPRTQGMIQEPALPPGWEMKYTSEGIRYFVDHNKRATTFKD 332

  Fly   619 -----------AGQAVPYSRDYKQKYEYFKSHIRKPTNVPNKFEIRIRRTSILEDSYRIISSVTK 672
                       .|....|.|.::.||..|: .:.....:|:..:|.:.|.::.|||::.|.::..
 Frog   333 PRPGFDSGVKQGGSPGAYDRSFRWKYHQFR-FLCHSNALPSHVKISVSRQTLFEDSFQQIMNMKP 396

  Fly   673 TDLLKTKLWVEFEGETGLDYGGLAREWFYLLSKEMFNPYYGLFEYSAMDNYTLQINNGSGLCNEE 737
            .| |:.:|::...||.||||||:|||||:|||.|:.||.|.||||:..:||.||||..|.: |.:
 Frog   397 YD-LRRRLYIIMRGEEGLDYGGIAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSI-NPD 459

  Fly   738 HLSYFKFIGRIAGMAVYHGKLLDAFFIRPFYKMMLQKPIDLKDMESVDTEYYNSLMWIKEN--DP 800
            ||:||:||||...||:||||.:|..|..||||.||.|...|:|:||:|.|:|||:||||:|  :.
 Frog   460 HLTYFRFIGRFIAMALYHGKFIDTGFTLPFYKRMLNKKPTLRDLESIDPEFYNSIMWIKDNNLEE 524

  Fly   801 RILELTFCLDEDVFGQKSQHELKPGGANIDVTNENKDEYIKLVIEWRFVARVKEQMSSFLDGFGS 865
            ..|||.|..|.::.|:.:.|:||.||.||.||.|||:|:|.|:.:|||...|:||.::|||||..
 Frog   525 CELELYFVQDMEILGEVTSHKLKEGGENIRVTEENKEEFISLLTDWRFTRGVEEQTNAFLDGFKE 589

  Fly   866 IIPLNLIKIFDEHELELLMCGIQNIDVKDWRENTLYKGDYHMNHIIIQWFWRAVLSFSNEMRSRL 930
            ::||..::.|||.||||::||:|.||:.||::||:|: .|..|...:||||:.|....||.|.||
 Frog   590 VVPLEWLRYFDEKELELMLCGMQEIDIADWQKNTIYR-HYTKNSKQVQWFWQVVKEMDNEKRIRL 653

  Fly   931 LQFVTGTSRVPMNGFKELYGSNGPQMFTIEKWGTPNNFPRAHTCFNRLDLPPYEGYLQLKDKLIK 995
            |||||||.|:|:.||.||.||||||.|.|::.|.....||:||||||||||||:.|.|||:||:.
 Frog   654 LQFVTGTCRLPVGGFVELIGSNGPQKFCIDRVGKDTWLPRSHTCFNRLDLPPYKSYEQLKEKLLF 718

  Fly   996 AIEGSQGF 1003
            |||.::||
 Frog   719 AIEETEGF 726

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nedd4	NP_648993.1	C2_NEDD4_NEDD4L	71..204	CDD:175999
		WW	248..277	CDD:278809
		WW	531..560	CDD:278809	12/28 (43%)
		WW	581..613	CDD:197736	23/35 (66%)
		HECTc	650..1003	CDD:238033	186/354 (53%)
		HECTc	674..1003	CDD:214523	180/330 (55%)
wwp2	NP_001090841.1	WW	160..189	CDD:366073	7/28 (25%)
		WW	190..219	CDD:366073	12/28 (43%)
		WW	265..293	CDD:366073	19/28 (68%)
		WW	305..335	CDD:238122	0/29 (0%)
		HECTc	375..727	CDD:238033	188/355 (53%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000080
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2273
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.940