DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Edc3 and EDC3

DIOPT Version :9

Sequence 1:	NP_648992.1	Gene:	Edc3 / 39957	FlyBaseID:	FBgn0036735	Length:	680	Species:	Drosophila melanogaster
Sequence 2:	NP_001135915.1	Gene:	EDC3 / 80153	HGNCID:	26114	Length:	508	Species:	Homo sapiens

Alignment Length:	691	Identity:	194/691 - (28%)
Similarity:	294/691 - (42%)	Gaps:	206/691 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 DWIGCAVSIACDEVLGVFQGLIKQIS--AEEITIVRAFRNG----VPLRKQNAEVVLKCTDIRSI 65
            ||:|..|||.|.:.|||:||.:..:.  ::.|::.|.|.||    ||      ||..:..||..:
Human     4 DWLGSIVSINCGDSLGVYQGRVSAVDQVSQTISLTRPFHNGVKCLVP------EVTFRAGDITEL 62

  Fly    66 DLIEPAKQDLDGHTAPPPVVNKPTPVKLPHFSNILGKQQQLQLQQQQQQLQLQQQQKQQFQEQER 130
            .::|          .|.|..|:       ||.
Human    63 KILE----------IPGPGDNQ-------HFG--------------------------------- 77

  Fly   131 EQDLPSTPRSRANDNGRVAAGGASSSSGPRGNFNSALSDKMHQLKLIETNGSNGTLRTPQTSRAS 195
              ||..|         .:...||....|                  |..||:...::.|.:|  |
Human    78 --DLHQT---------ELGPSGAGCQVG------------------INQNGTGKFVKKPASS--S 111

  Fly   196 SAQQQPQISTTPNSVAAFFGNMIPPKVEVKLGSYVSNTRESYCSSSGDSGEATGLSLGSSKPIDI 260
            ||.|.                 ||.:.:||......:.::..||.|........||...|
Human   112 SAPQN-----------------IPKRTDVKSQDVAVSPQQQQCSKSYVDRHMESLSQSKS----- 154

  Fly   261 VSNGDGFYKQTAASSYGNTNGNVRRNGNANNNGNGTGNGSYTNGNG--NGNGKNKRNRVRRESSM 323
                                  .||..|:.::.:...|.:....:|  ||..|||.:.
Human   155 ----------------------FRRRHNSWSSSSRHPNQATPKKSGLKNGQMKNKDDE------- 190

  Fly   324 RQQQVQLTFGSEADDPLIHEDFDFEGNLALFDKQAIWDDIESTTQKPDVVRHIVNNHHHKPEQKY 388
                   .||.:.:: :...|||||||||||||.|::::|::..::.......:.|  .:| .:|
Human   191 -------CFGDDIEE-IPDTDFDFEGNLALFDKAAVFEEIDTYERRSGTRSRGIPN--ERP-TRY 244

  Fly   389 RHDENILASKPLQLRQIESMFGGSQDFVTDDGLIIPTIPAYVRNKIEISADKAGLSLQRQIDILA 453
            |||||||.|:|:..|:|......|::|.||.||::|:|...:..|:...|:|.||:|:|::::..
Human   245 RHDENILESEPIVYRRIIVPHNVSKEFCTDSGLVVPSISYELHKKLLSVAEKHGLTLERRLEMTG 309

  Fly   454 RGASDLAITLLGGARRLTPANNHQWPKIAIICDGGKNMRTINIGAATGRQLASHGLTVLLYVEQ- 517
            ..||.:|:|||||..||.|.|.||.|.:|::|  |.:::... |.:.||.||:|.:.|:|::..
Human   310 VCASQMALTLLGGPNRLNPKNVHQRPTVALLC--GPHVKGAQ-GISCGRHLANHDVQVILFLPNF 371

  Fly   518 AKLLEQNSSSPEISLFKATDNVIVHSVDALPTP--DLVILSTNTAN---LSD-----AIRKWLSV 572
            .|:||  |.:.|:|||..|....|.|:..|||.  ||||...:...   |.|     |...|.:.
Human   372 VKMLE--SITNELSLFSKTQGQQVSSLKDLPTSPVDLVINCLDCPENVFLRDQPWYKAAVAWANQ 434

  Fly   573 NRASVLAIDPPPCGINEVAIKYSILPILPLNGISTATTSSSSSAAATPTPIASTSAAASATKSAA 637
            |||.||:||||   ::||.           .||.    :..|.|...|.|:.
Human   435 NRAPVLSIDPP---VHEVE-----------QGID----AKWSLALGLPLPLG------------- 468

  Fly   638 STNNCGKLYLCNLGIPDKFYRDCGIKYKSPYGHKYVIPIHS 678
              .:.|::|||::|||.:.:::.||.|.||:|.|:|||:||
Human   469 --EHAGRIYLCDIGIPQQVFQEVGINYHSPFGCKFVIPLHS 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Edc3	NP_648992.1	LSm16_N	5..69	CDD:212484	23/67 (34%)
		FDF	343..>397	CDD:286601	25/53 (47%)
		YjeF_N	453..583	CDD:294225	55/140 (39%)
EDC3	NP_001135915.1	Required for P-body targeting and interaction with DCP1A. /evidence=ECO:0000250	1..79		29/132 (22%)
		LSm16_N	2..66	CDD:212484	23/67 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	95..192		29/156 (19%)
		Edc3_linker	104..197	CDD:318741	28/152 (18%)
		Required for interaction with DDX6. /evidence=ECO:0000250	191..296		41/108 (38%)
		FDF	199..300	CDD:312888	41/103 (40%)
		YjeF_N	302..455	CDD:281800	62/175 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155715
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0062
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11827
Inparanoid	1	1.050	233	1.000	Inparanoid score	I3430
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D412946at33208
OrthoFinder	1	1.000	-	-		FOG0006369
OrthoInspector	1	1.000	-	-		oto88346
orthoMCL	1	0.900	-	-		OOG6_106564
Panther	1	1.100	-	-	LDO	PTHR13612
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6031
SonicParanoid	1	1.000	-	-		X6088
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.790