DRSC/TRiP Functional Genomics Resources

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Protein Alignment Edc3 and EDC3

DIOPT Version :10

Sequence 1:NP_648992.1 Gene:Edc3 / 39957 FlyBaseID:FBgn0036735 Length:680 Species:Drosophila melanogaster
Sequence 2:NP_079359.2 Gene:EDC3 / 80153 HGNCID:26114 Length:508 Species:Homo sapiens


Alignment Length:691 Identity:194/691 - (28%)
Similarity:294/691 - (42%) Gaps:206/691 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly     7 DWIGCAVSIACDEVLGVFQGLIKQIS--AEEITIVRAFRNG----VPLRKQNAEVVLKCTDIRSI 65
            ||:|..|||.|.:.|||:||.:..:.  ::.|::.|.|.||    ||      ||..:..||..:
Human     4 DWLGSIVSINCGDSLGVYQGRVSAVDQVSQTISLTRPFHNGVKCLVP------EVTFRAGDITEL 62

  Fly    66 DLIEPAKQDLDGHTAPPPVVNKPTPVKLPHFSNILGKQQQLQLQQQQQQLQLQQQQKQQFQEQER 130
            .::|          .|.|..|:       ||.                                 
Human    63 KILE----------IPGPGDNQ-------HFG--------------------------------- 77

  Fly   131 EQDLPSTPRSRANDNGRVAAGGASSSSGPRGNFNSALSDKMHQLKLIETNGSNGTLRTPQTSRAS 195
              ||..|         .:...||....|                  |..||:...::.|.:|  |
Human    78 --DLHQT---------ELGPSGAGCQVG------------------INQNGTGKFVKKPASS--S 111

  Fly   196 SAQQQPQISTTPNSVAAFFGNMIPPKVEVKLGSYVSNTRESYCSSSGDSGEATGLSLGSSKPIDI 260
            ||.|.                 ||.:.:||......:.::..||.|........||...|     
Human   112 SAPQN-----------------IPKRTDVKSQDVAVSPQQQQCSKSYVDRHMESLSQSKS----- 154

  Fly   261 VSNGDGFYKQTAASSYGNTNGNVRRNGNANNNGNGTGNGSYTNGNG--NGNGKNKRNRVRRESSM 323
                                  .||..|:.::.:...|.:....:|  ||..|||.:.       
Human   155 ----------------------FRRRHNSWSSSSRHPNQATPKKSGLKNGQMKNKDDE------- 190

  Fly   324 RQQQVQLTFGSEADDPLIHEDFDFEGNLALFDKQAIWDDIESTTQKPDVVRHIVNNHHHKPEQKY 388
                   .||.:.:: :...|||||||||||||.|::::|::..::.......:.|  .:| .:|
Human   191 -------CFGDDIEE-IPDTDFDFEGNLALFDKAAVFEEIDTYERRSGTRSRGIPN--ERP-TRY 244

  Fly   389 RHDENILASKPLQLRQIESMFGGSQDFVTDDGLIIPTIPAYVRNKIEISADKAGLSLQRQIDILA 453
            |||||||.|:|:..|:|......|::|.||.||::|:|...:..|:...|:|.||:|:|::::..
Human   245 RHDENILESEPIVYRRIIVPHNVSKEFCTDSGLVVPSISYELHKKLLSVAEKHGLTLERRLEMTG 309

  Fly   454 RGASDLAITLLGGARRLTPANNHQWPKIAIICDGGKNMRTINIGAATGRQLASHGLTVLLYVEQ- 517
            ..||.:|:|||||..||.|.|.||.|.:|::|  |.:::... |.:.||.||:|.:.|:|::.. 
Human   310 VCASQMALTLLGGPNRLNPKNVHQRPTVALLC--GPHVKGAQ-GISCGRHLANHDVQVILFLPNF 371

  Fly   518 AKLLEQNSSSPEISLFKATDNVIVHSVDALPTP--DLVILSTNTAN---LSD-----AIRKWLSV 572
            .|:||  |.:.|:|||..|....|.|:..|||.  ||||...:...   |.|     |...|.:.
Human   372 VKMLE--SITNELSLFSKTQGQQVSSLKDLPTSPVDLVINCLDCPENVFLRDQPWYKAAVAWANQ 434

  Fly   573 NRASVLAIDPPPCGINEVAIKYSILPILPLNGISTATTSSSSSAAATPTPIASTSAAASATKSAA 637
            |||.||:||||   ::||.           .||.    :..|.|...|.|:.             
Human   435 NRAPVLSIDPP---VHEVE-----------QGID----AKWSLALGLPLPLG------------- 468

  Fly   638 STNNCGKLYLCNLGIPDKFYRDCGIKYKSPYGHKYVIPIHS 678
              .:.|::|||::|||.:.:::.||.|.||:|.|:|||:||
Human   469 --EHAGRIYLCDIGIPQQVFQEVGINYHSPFGCKFVIPLHS 507

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Edc3NP_648992.1 LSm16_N 5..69 CDD:212484 23/67 (34%)
FDF 343..>397 CDD:430668 25/53 (47%)
YjeF_N 453..583 CDD:444831 55/140 (39%)
EDC3NP_079359.2 Required for P-body targeting and interaction with DCP1A. /evidence=ECO:0000250 1..79 29/132 (22%)
LSm16_N 2..66 CDD:212484 23/67 (34%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 95..192 29/156 (19%)
Edc3_linker 102..194 CDD:465188 27/151 (18%)
Required for interaction with DDX6. /evidence=ECO:0000250 191..296 41/108 (38%)
FDF 198..301 CDD:430668 42/106 (40%)
YjeF_N 302..455 CDD:427546 62/175 (35%)

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