DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Edc3 and edc3

DIOPT Version :9

Sequence 1:	NP_648992.1	Gene:	Edc3 / 39957	FlyBaseID:	FBgn0036735	Length:	680	Species:	Drosophila melanogaster
Sequence 2:	NP_595858.1	Gene:	edc3 / 2540639	PomBaseID:	SPBC18E5.11c	Length:	454	Species:	Schizosaccharomyces pombe

Alignment Length:	514	Identity:	105/514 - (20%)
Similarity:	190/514 - (36%)	Gaps:	140/514 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   209 SVAAFFGNMIPPKVEVKLGSYVSNTRESYCSSSGDSGEATGLSLGSSKPIDIVSNGDGFYKQTAA 273
            |||.|:|:    .|||.|.:  .:......::...|.....|.|.:.....||:      |....
pombe     2 SVADFYGS----NVEVLLNN--DSKARGVITNFDSSNSILQLRLANDSTKSIVT------KDIKD 54

  Fly   274 SSYGNTNGNVRRNGNANNNGNGT---GNGSYTNGNGNGNGKNKRNRVRRESSMRQQQVQLTFGSE 335
            ......|..:.:||..:.:.|.|   ...:|::       |||                  :..:
pombe    55 LRILPKNEIMPKNGTKSPSTNSTKLKSAETYSS-------KNK------------------WSMD 94

  Fly   336 ADDPLIHEDFDFEGNLALFDKQAIWDDIESTTQKPDVVRHIVNNHHHKPEQKYRHDENILA---- 396
            .|     |:|||..||..|||:.::.:.....:| |..:.:| :|:..|.:.|.|.:|:|.
pombe    95 CD-----EEFDFAANLEKFDKKQVFAEFREKDKK-DPAKLLV-SHNKSPNRNYHHKQNVLGPSVK 152

  Fly   397 -------SKPLQLRQIESMFGGSQD-------------------FV----------TDDGLIIPT 425
                   |...|:..|:::...|.:                   ||          |...::.|.
pombe   153 DEFVDLPSAGSQINGIDAVLSSSSNGHVTPGSKKGSRETLKKKPFVDENIPAELHTTTGDILKPI 217

  Fly   426 IPAYVRNKIEISADKAGLSLQRQIDILARGASDL----AITLLGGARRLTPANNHQWPKIAIICD 486
            .|..:...|.::..|.      ..||:...|:.|    ..::|||.:||:..|::..|.:.|:..
pombe   218 TPEQLSQGIALAIAKT------STDIVVENAAQLLSQFVFSVLGGHKRLSSRNHNSQPLVCILVG 276

  Fly   487 GGKNMRTINIGAATGRQLASHGLTVLLYVEQAKLLEQNSSSPEISLFKATDNVIV-----HSVDA 546
            ...:   .:...|.||:|.:.|:.|:|.:    |...|..:.::.:|:|....|.     ..::.
pombe   277 SHDH---ASAAVAAGRRLCAIGIKVVLRL----LTPFNVDNRQLLMFQAAGGYIPTENFDQFLNK 334

  Fly   547 LPTPDLVILSTNTA------NLSDAIRKWLSVNRASVLAIDPPPCGINEVAIKYSILP--ILPLN 603
            |.:|..:::...|.      ..|.|:.:|.:.....:|::| .|.|........:|||  .|.|.
pombe   335 LTSPIELVVDVLTGFHPSIDKNSHALIQWANDLNVLILSVD-IPSGYTVQKKNTAILPKWTLALG 398

  Fly   604 GISTATTSSSSSAAATPTPIASTSAAASATKSAASTNNCGKLYLCNLGIPDKFYRDCGI 662
            .::|                  |.|.|:..|.||..:    :::.|||...:.:.:.||
pombe   399 AVTT------------------TLAQAALVKQAAGVS----VFVGNLGTGSQTWAELGI 435

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Edc3	NP_648992.1	LSm16_N	5..69	CDD:212484
		FDF	343..>397	CDD:286601	18/64 (28%)
		YjeF_N	453..583	CDD:294225	30/144 (21%)
edc3	NP_595858.1	LSm16_N	3..59	CDD:212484	14/67 (21%)
		FDF	94..186	CDD:286601	23/98 (23%)
		YjeF_N	236..402	CDD:281800	39/173 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0062
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006369
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_106564
Panther	1	1.100	-	-	LDO	PTHR13612
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6031
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.840