DRSC/TRiP Functional Genomics Resources

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Protein Alignment U4-U6-60K and PRP4

DIOPT Version :9

Sequence 1:NP_648990.1 Gene:U4-U6-60K / 39955 FlyBaseID:FBgn0036733 Length:553 Species:Drosophila melanogaster
Sequence 2:NP_015504.1 Gene:PRP4 / 856307 SGDID:S000006382 Length:465 Species:Saccharomyces cerevisiae


Alignment Length:505 Identity:157/505 - (31%)
Similarity:263/505 - (52%) Gaps:61/505 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly    61 LEDIDSDEDYEESTKKTSNAKQAGAPPPTAATLANKIDDDYFDLEMEMERDKV-ALLEEFERKKR 124
            ||::..|..::.:|:..|.|                      |:..::..::: |:||:      
Yeast     7 LENLPVDLQHKGATQNESTA----------------------DILKQLPHERLQAVLEK------ 43

  Fly   125 ARQINVSTDDTEIKSNLRQLNEPICYFGEGPAERRRRLKELL----AGLGENAINKRQYEDEERK 185
                 :..:|.|::..|..|.:|.....|...:||.||.|:|    ..| ||..|......||  
Yeast    44 -----IPEEDLEVRRLLSILKKPEVVENEDVQQRRIRLAEILMVDEIDL-ENINNMENINGEE-- 100

  Fly   186 QQQREQDQATWYHEGPDSLRIARLWLADYSLPRAKDRLVRAREALEVPSAAR--AGRMVEMQKKL 248
              ..|:|...::......|..||.:|.:|||.|::.||.:..|..:..:..:  ..|..|:| ::
Yeast   101 --VDEEDDEDFFTPATSELIFARRFLINYSLERSRKRLQKEMERHQKFNTRQELLSRRTELQ-RM 162

  Fly   249 QSLAPLCSQVGDTRPVSSAAFSEDSSLLLTSSWSGLCKLWSVPDCE-LKQTLRGHASYVGGVALR 312
            .:|....||:..|:|:|:.:.|.|..::.|.||:|..::.:....: |.|.|..|...:|.:...
Yeast   163 ANLELAGSQLVSTKPISAVSLSTDDMVVATGSWAGDLQVLNSQTLQPLTQKLDSHVGKIGAIDWH 227

  Fly   313 PGVKADEENVVAMASGGHDGAVKLWGFNNEES----IADITGHMPHRVSKVAFHPSGRFLATACY 373
            |    |..|  .|.|...||.:|.:.::|||.    :.|:.|| ..|:|.|.:||||:|:.:|.:
Yeast   228 P----DSNN--QMISCAEDGLIKNFQYSNEEGGLRLLGDLVGH-ERRISDVKYHPSGKFIGSASH 285

  Fly   374 DSSWRLWDLEQKTEVLHQEGHAKPVHCLSYHSDGSVLVTGGLDAFGRVWDLRTGRCIMFLEGHLG 438
            |.:|||||.....|:|.||||.|.|..||:..|||::.:||:|:...:||:|:|..:|.|.||..
Yeast   286 DMTWRLWDASTHQELLLQEGHDKGVFSLSFQCDGSLVCSGGMDSLSMLWDIRSGSKVMTLAGHSK 350

  Fly   439 AVFGVDFSPNGFHIATGSQDNTCKIWDLRRRQ--PVYTIPAHTNLISDVKYQQE-CGSFLVTCSY 500
            .::.|.:||||:.:|||..|....:||:|:|.  .:..|.||.|:::.|::.:| .|..||:|.|
Yeast   351 PIYTVAWSPNGYQVATGGGDGIINVWDIRKRDEGQLNQILAHRNIVTQVRFSKEDGGKKLVSCGY 415

  Fly   501 DSTTKIWSNKTWQPLKTLQGHDNKVISVDIAPNSQYIATTSFDRTFKLWS 550
            |:...::|:.||..:.:|.||.:|:||:||:.||.::.:..:||:.|||:
Yeast   416 DNLINVYSSDTWLKMGSLAGHTDKIISLDISNNSHFLVSGGWDRSIKLWN 465

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
U4-U6-60KNP_648990.1 SFM 132..>166 CDD:128776 11/33 (33%)
WD40 repeat 264..301 CDD:293791 10/37 (27%)
WD40 <286..553 CDD:225201 101/273 (37%)
WD40 286..550 CDD:238121 100/271 (37%)
WD40 repeat 357..393 CDD:293791 17/35 (49%)
WD40 repeat 398..434 CDD:293791 14/35 (40%)
WD40 repeat 441..476 CDD:293791 13/36 (36%)
WD40 repeat 482..519 CDD:293791 11/37 (30%)
WD40 repeat 525..551 CDD:293791 11/26 (42%)
PRP4NP_015504.1 HIP1_clath_bdg 128..175 CDD:406822 12/47 (26%)
WD40 175..465 CDD:238121 109/296 (37%)
WD40 repeat 178..216 CDD:293791 10/37 (27%)
WD40 repeat 222..263 CDD:293791 13/46 (28%)
WD40 repeat 268..304 CDD:293791 16/35 (46%)
WD40 repeat 311..346 CDD:293791 13/34 (38%)
WD40 repeat 352..387 CDD:293791 13/34 (38%)
WD40 repeat 396..434 CDD:293791 11/37 (30%)
WD40 repeat 440..464 CDD:293791 9/23 (39%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C157343604
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0272
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H3446
Inparanoid 1 1.050 246 1.000 Inparanoid score I671
Isobase 1 0.950 - 0 Normalized mean entropy S1130
OMA 1 1.010 - - QHG54420
OrthoFinder 1 1.000 - - FOG0004342
OrthoInspector 1 1.000 - - oto99837
orthoMCL 1 0.900 - - OOG6_102752
Panther 1 1.100 - - LDO PTHR19846
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1883
SonicParanoid 1 1.000 - - X3609
TreeFam 1 0.960 - -
1514.740

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