Protein Alignment U4-U6-60K and Prpf4

DIOPT Version :10

• Sequence 1: NP_648990.1
• Gene: U4-U6-60K / 39955
• FlyBaseID: FBgn0036733
• Length: 553
• Species: Drosophila melanogaster
• Sequence 2: NP_081573.1
• Gene: Prpf4 / 70052
• MGIID: 1917302
• Length: 521
• Species: Mus musculus
• Alignment Length: 548
• Identity: 276/548 - (50%)
• Similarity: 367/548 - (66%)
• Gaps: 48/548 - (8%)

  Fly     4 DDDIQYIKRQRTLHYGSLEESERKRQNAAASGAAATTTSGTTASSGAGTTTTGTGGQLEDIDSDE 68
            ||.:..:.::..::||||||.||:|.....||...  ..|..|...||.....:|
Mouse    17 DDLVAPVVKKPHIYYGSLEEKERERLAKGESGILG--KEGLKAGIEAGNINITSG---------- 69

  Fly    69 DYEESTKKTSNAKQAGAPPPTAATLANKIDDDYFDLEMEMERDKVALLEEFERKKRARQINVSTD 133
                                           :.|::|..:...:..:|.||||:|||||||||||
Mouse    70 -------------------------------EVFEIEEHISERQAEVLAEFERRKRARQINVSTD 103

  Fly   134 DTEIKSNLRQLNEPICYFGEGPAERRRRLKELLAGLGENAINKRQYEDEERKQQQREQDQATWYH 198
            |:|:|:.||.|.|||..|||||||||.||:.:|:.:|.:|:.|.: :|:|:.::.:|:.|.||||
Mouse   104 DSEVKACLRALGEPITLFGEGPAERRERLRNILSVVGTDALKKTK-KDDEKSKKSKEEYQQTWYH 167

  Fly   199 EGPDSLRIARLWLADYSLPRAKDRLVRAREALEVPSAARAGRMVEMQKKLQSLAPLCSQVGDTRP 263
            |||:||::||||:|:||||||..||..||...|:|...|..:|.|:.|.|:||...|||:||.||
Mouse   168 EGPNSLKVARLWIANYSLPRAMKRLEEARLHKEIPETTRTSQMQELHKSLRSLNNFCSQIGDDRP 232

  Fly   264 VSSAAFSEDSSLLLTSSWSGLCKLWSVPDCELKQTLRGHASYVGGVALRP--GVKADEENVVAMA 326
            :|...||.:|.:|.|:.|||||||||||||.|..|||||.:.||.:...|  .|..|::: |.:|
Mouse   233 ISYCHFSPNSKMLATACWSGLCKLWSVPDCSLLHTLRGHNTNVGAIVFHPKSTVSLDQKD-VNLA 296

  Fly   327 SGGHDGAVKLWGFNNEESIADITGHMPHRVSKVAFHPSGRFLATACYDSSWRLWDLEQKTEVLHQ 391
            |...||:||||..:::|.:|||.||.. ||::|.:|||||||.|.|||.||||||||.:.|:|||
Mouse   297 SCAADGSVKLWSLDSDEPVADIEGHTV-RVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEILHQ 360

  Fly   392 EGHAKPVHCLSYHSDGSVLVTGGLDAFGRVWDLRTGRCIMFLEGHLGAVFGVDFSPNGFHIATGS 456
            |||:..|:.:::|.|||:..||||||||||||||||||||||||||..::|::|||||:||||||
Mouse   361 EGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSPNGYHIATGS 425

  Fly   457 QDNTCKIWDLRRRQPVYTIPAHTNLISDVKYQQECGSFLVTCSYDSTTKIWSNKTWQPLKTLQGH 521
            .|||||:||||:|:.|||||||.||::.||::...|.||:|.:||:|.|||::..|.|||||.||
Mouse   426 GDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGDFLLTGAYDNTAKIWTHPGWSPLKTLAGH 490

  Fly   522 DNKVISVDIAPNSQYIATTSFDRTFKLW 549
            :.||:.:||:.:.|.|||.|:|||||||
Mouse   491 EGKVMGLDISSDGQLIATCSYDRTFKLW 518

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
U4-U6-60K	NP_648990.1	CCDC66	<113..>194	CDD:434558	43/80 (54%)
		SFM	132..>166	CDD:128776	22/33 (67%)
		WD40 repeat	264..301	CDD:293791	22/36 (61%)
		WD40	<286..553	CDD:441893	161/266 (61%)
		WD40 repeat	357..393	CDD:293791	24/35 (69%)
		WD40 repeat	398..434	CDD:293791	26/35 (74%)
		WD40 repeat	441..476	CDD:293791	25/34 (74%)
		WD40 repeat	482..519	CDD:293791	17/36 (47%)
		WD40 repeat	525..551	CDD:293791	15/25 (60%)
Prpf4	NP_081573.1	SFM	102..140	CDD:128776	23/37 (62%)
		WD40	<228..518	CDD:441893	174/291 (60%)
		WD 1	228..267		24/38 (63%)
		WD40 repeat	233..270	CDD:293791	22/36 (61%)
		WD 2	270..317		17/47 (36%)
		WD40 repeat	284..320	CDD:293791	15/36 (42%)
		WD 3	320..359		25/39 (64%)
		WD40 repeat	325..361	CDD:293791	24/35 (69%)
		WD 4	362..401		26/38 (68%)
		WD40 repeat	368..403	CDD:293791	25/34 (74%)
		WD 5	404..443		26/38 (68%)
		WD40 repeat	409..443	CDD:293791	23/33 (70%)
		WD 6	446..486		19/39 (49%)
		WD40 repeat	451..488	CDD:293791	17/36 (47%)
		WD 7	489..521		18/30 (60%)
		WD40 repeat	494..518	CDD:293791	13/23 (57%)