DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment U4-U6-60K and daw1

DIOPT Version :9

Sequence 1:NP_648990.1 Gene:U4-U6-60K / 39955 FlyBaseID:FBgn0036733 Length:553 Species:Drosophila melanogaster
Sequence 2:NP_001037817.1 Gene:daw1 / 556760 ZFINID:ZDB-GENE-050419-255 Length:418 Species:Danio rerio


Alignment Length:342 Identity:99/342 - (28%)
Similarity:160/342 - (46%) Gaps:33/342 - (9%)


- Green bases have known domain annotations that are detailed below.


  Fly   224 VRAREALEVPSAARAGRMV--EMQKKLQSLAPLCSQVGDTR------------PVSSAAFSEDSS 274
            :||.|.|...|.....:::  ::|:|:       ||..:.:            |:::.||::..|
Zfish    48 IRAAEPLITSSCVEQVKLLICKLQEKV-------SQKDERKFYLFRALQAHILPLTNVAFNKSGS 105

  Fly   275 LLLTSSWSGLCKLWSVPDCELKQTLRGHASYVGGVALRP--GVKADEENVVAMASGGHDGAVKLW 337
            ..:|.|:...||:|.....|...||.||.:.|..:|...  |.|        :|:|..|...|||
Zfish   106 CFITGSYDRTCKIWDTASGEELHTLEGHRNVVYAIAFNNPYGDK--------VATGSFDKTCKLW 162

  Fly   338 GFNNEESIADITGHMPHRVSKVAFHPSGRFLATACYDSSWRLWDLEQKTEVLHQEGHAKPVHCLS 402
            .....:......||....|. :||:|....:||...|::.:|||:|...||....||...:..|.
Zfish   163 SAETGKCFYTFRGHTAEIVC-LAFNPQSTLVATGSMDTTAKLWDVESGEEVSTLAGHFAEIISLC 226

  Fly   403 YHSDGSVLVTGGLDAFGRVWDLRTGRCIMFLEGHLGAVFGVDFSPNGFHIATGSQDNTCKIWDLR 467
            :::.|..||||..|....:||:.:||.:..|.||.|.:..|.|:.:...|||.|.|.:||:||..
Zfish   227 FNTTGDRLVTGSFDHTAILWDVPSGRKVHVLSGHRGEISCVQFNWDCSLIATASLDKSCKVWDAE 291

  Fly   468 RRQPVYTIPAHTNLISDVKYQQECGSFLVTCSYDSTTKIWSNKTWQPLKTLQGHDNKVISVDIAP 532
            ..|.:.|:..|.:.:.||.:.. .|..:.|.|.|.|::::|..|:|.|..|:||..::..|....
Zfish   292 GGQCLATLLGHNDEVLDVCFNY-TGQLIATASADGTSRVFSTDTFQCLCQLEGHKGEISKVCFNA 355

  Fly   533 NSQYIATTSFDRTFKLW 549
            ....:.|.|.|:|.::|
Zfish   356 QGSRVLTASVDKTSRVW 372

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
U4-U6-60KNP_648990.1 SFM 132..>166 CDD:128776
WD40 repeat 264..301 CDD:293791 11/36 (31%)
WD40 <286..553 CDD:225201 83/266 (31%)
WD40 286..550 CDD:238121 83/266 (31%)
WD40 repeat 357..393 CDD:293791 12/35 (34%)
WD40 repeat 398..434 CDD:293791 11/35 (31%)
WD40 repeat 441..476 CDD:293791 13/34 (38%)
WD40 repeat 482..519 CDD:293791 11/36 (31%)
WD40 repeat 525..551 CDD:293791 6/25 (24%)
daw1NP_001037817.1 CEP19 4..>81 CDD:291594 9/39 (23%)
WD40 84..372 CDD:238121 89/297 (30%)
WD40 88..405 CDD:225201 90/295 (31%)
WD 1 90..129 10/38 (26%)
WD40 repeat 95..132 CDD:293791 11/36 (31%)
WD 2 132..172 12/47 (26%)
WD40 repeat 137..175 CDD:293791 10/45 (22%)
WD 3 175..214 15/39 (38%)
WD40 repeat 181..217 CDD:293791 13/36 (36%)
WD 4 217..256 13/38 (34%)
WD40 repeat 222..258 CDD:293791 11/35 (31%)
WD 5 259..298 15/38 (39%)
WD40 repeat 265..300 CDD:293791 13/34 (38%)
WD 6 301..340 12/39 (31%)
WD40 repeat 306..342 CDD:293791 11/36 (31%)
WD 7 343..384 8/30 (27%)
WD40 repeat 348..384 CDD:293791 6/25 (24%)
WD40 376..>405 CDD:197651
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0272
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
32.810

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