DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment U4-U6-60K and Daw1

DIOPT Version :9

Sequence 1:	NP_648990.1	Gene:	U4-U6-60K / 39955	FlyBaseID:	FBgn0036733	Length:	553	Species:	Drosophila melanogaster
Sequence 2:	NP_001020196.1	Gene:	Daw1 / 363267	RGDID:	1561436	Length:	415	Species:	Rattus norvegicus

Alignment Length:	289	Identity:	84/289 - (29%)
Similarity:	136/289 - (47%)	Gaps:	12/289 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly   263 PVSSAAFSEDSSLLLTSSWSGLCKLWSVPDCELKQTLRGHASYVGGVALRP--GVKADEENVVAM 325
            |:::.|.::..|..:|.|:...||:|.....|...||.||.:.|..:|...  |.|        :
  Rat    94 PLTNVALNKAGSCFITGSYDRTCKVWDTASGEELHTLEGHRNVVYAIAFNNPYGDK--------I 150

  Fly   326 ASGGHDGAVKLWGFNNEESIADITGHMPHRVSKVAFHPSGRFLATACYDSSWRLWDLEQKTEVLH 390
            |:|..|...|||.....:......||....|. ::|:|....:||...|::.:|||::...||:.
  Rat   151 ATGSFDKTCKLWSAETGKCYHTFRGHTAEIVC-LSFNPQSTVVATGSMDTTAKLWDIQSGEEVVT 214

  Fly   391 QEGHAKPVHCLSYHSDGSVLVTGGLDAFGRVWDLRTGRCIMFLEGHLGAVFGVDFSPNGFHIATG 455
            ..||...:..||:.:.|..::||..|....|||..|||.:..|.||...:....||.:...|.||
  Rat   215 LTGHLAEIISLSFDTSGDRIITGSFDHTVVVWDASTGRKVHTLIGHCAEISSALFSWDCSLILTG 279

  Fly   456 SQDNTCKIWDLRRRQPVYTIPAHTNLISDVKYQQECGSFLVTCSYDSTTKIWSNKTWQPLKTLQG 520
            |.|.||.:||....:.|.|:..|.:.|.|..:.. .|..:.|.|.|.|.::::..|.:.:..|:|
  Rat   280 SMDKTCMLWDATSGKCVATLTGHDDEILDSCFDY-TGKLIATASADGTARVYNATTRKCITKLEG 343

  Fly   521 HDNKVISVDIAPNSQYIATTSFDRTFKLW 549
            |:.::..:...|....:.|.|.|:|.::|
  Rat   344 HEGEISKISFNPQGNRLLTGSSDKTARIW 372

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
U4-U6-60K	NP_648990.1	SFM	132..>166	CDD:128776
		WD40 repeat	264..301	CDD:293791	10/36 (28%)
		WD40	<286..553	CDD:225201	78/266 (29%)
		WD40	286..550	CDD:238121	78/266 (29%)
		WD40 repeat	357..393	CDD:293791	10/35 (29%)
		WD40 repeat	398..434	CDD:293791	12/35 (34%)
		WD40 repeat	441..476	CDD:293791	13/34 (38%)
		WD40 repeat	482..519	CDD:293791	8/36 (22%)
		WD40 repeat	525..551	CDD:293791	6/25 (24%)
Daw1	NP_001020196.1	WD40	86..120	CDD:197651	7/25 (28%)
		WD 1	90..129		9/34 (26%)
		WD40 repeat	96..132	CDD:293791	10/35 (29%)
		WD40	126..415	CDD:238121	75/257 (29%)
		WD 2	132..174		12/49 (24%)
		WD40 repeat	137..175	CDD:293791	10/45 (22%)
		WD 3	175..214		13/39 (33%)
		WD40 repeat	181..217	CDD:293791	11/36 (31%)
		WD 4	217..256		14/38 (37%)
		WD40 repeat	222..258	CDD:293791	12/35 (34%)
		WD 5	259..298		14/38 (37%)
		WD40 repeat	265..300	CDD:293791	13/34 (38%)
		WD 6	301..340		9/39 (23%)
		WD40 repeat	306..342	CDD:293791	8/36 (22%)
		WD 7	343..384		8/30 (27%)
		WD40 repeat	348..384	CDD:293791	6/25 (24%)
		WD 8	386..415
		WD40 repeat	390..414	CDD:293791
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0272
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810