Protein Alignment U4-U6-60K and rna4

DIOPT Version :10

• Sequence 1: NP_648990.1
• Gene: U4-U6-60K / 39955
• FlyBaseID: FBgn0036733
• Length: 553
• Species: Drosophila melanogaster
• Sequence 2: NP_592966.1
• Gene: rna4 / 2541477
• PomBaseID: SPAC227.12
• Length: 462
• Species: Schizosaccharomyces pombe
• Alignment Length: 452
• Identity: 162/452 - (35%)
• Similarity: 260/452 - (57%)
• Gaps: 25/452 - (5%)

  Fly   110 RDKVALLEEFERKKRARQINVSTDDTEIKSNLRQLNEPICYFGEGPAERRRRLKELLAGL---GE 171
            :::.|...|.:.|.|.:.:.:..:|::::..||:..|||.||||....||:||::|:...   |:
pombe    26 KEQAAYYAEQKEKDRIKALKIPYEDSKVREYLRRYGEPITYFGEDALARRQRLQQLMIEKSLEGD 90

  Fly   172 NAINKRQYEDEERKQQQREQDQATWYHEGPDSLRIARLWLADYSLPRAKDRLVRAREALE--VPS 234
            |.::..|...|..:::.        |.:|...|.:||..:|.|||.:||.||.:.||..|  ||.
pombe    91 NPLDVDQGASENIEKET--------YVQGSHELLVARKKIALYSLEKAKLRLKKEREISEIPVPE 147

  Fly   235 AARAGR-MVEMQKKLQSLAPLCSQVGDTRPVSSAAFSEDSSLLLTSSWSGLCKLWSVPDCELKQT 298
            ...:|: .:|..:|.:.:.   ||:|..||::...||.:.:...:.||.|..|:|:..:....|.
pombe   148 IVLSGKSSIEHLQKAELMG---SQIGGERPIAIVRFSNNGNHFASGSWGGQVKVWNSDNLSEVQL 209

  Fly   299 LRGHASYVGGVALRP---GVKADEENVVAMASGGHDGAVKLWGFNNEESIADITGHMPHRVSKVA 360
            .|||...|.|:...|   ...||.|. :.:|:|..|..|.||..:....:..:.||:. ||.:||
pombe   210 FRGHTDRVSGLDWYPLCQAWDADSEQ-LTLATGAADNTVCLWKASQSTPLLRLEGHLA-RVGRVA 272

  Fly   361 FHPSGRFLATACYDSSWRLWDLEQKTEVLHQEGHAKPVHCLSYHSDGSVLVTGGLDAFGRVWDLR 425
            |||||.:|.:|.:|::|||||:....|:|.||||::.:..::...|||::.:||.||.||:||||
pombe   273 FHPSGDYLVSASFDTTWRLWDVHTGVELLMQEGHSEGIFSIACQPDGSLVSSGGNDAIGRIWDLR 337

  Fly   426 TGRCIMFLEGHLGAVFGVDFSPNGFHIATGSQDNTCKIWDLRRRQPVYTIPAHTNLISDVKY-QQ 489
            :|:.||.|:.|:..:..:.:||||:.:||.|.|:|.||||||:....:|||||::|:|||:| :.
pombe   338 SGKSIMVLDEHIRQIVAMAWSPNGYQLATSSADDTVKIWDLRKVSLAHTIPAHSSLVSDVRYIES 402

  Fly   490 ECGSFLVTCSYDSTTKIWSNKTWQPLKTLQGHDNKVISVDIAPNSQYIATTSFDRTFKLWSP 551
            ....|:.|..||...|:|:......:|::.||:.||:||| ....::| ::.:|||.|||.|
pombe   403 GVNRFIATSGYDGCVKLWNPLNCSLIKSMVGHEEKVMSVD-GYGDRFI-SSGYDRTIKLWYP 462

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
U4-U6-60K	NP_648990.1	CCDC66	<113..>194	CDD:434558	23/83 (28%)
		SFM	132..>166	CDD:128776	14/33 (42%)
		WD40 repeat	264..301	CDD:293791	8/36 (22%)
		WD40	<286..553	CDD:441893	108/270 (40%)
		WD40 repeat	357..393	CDD:293791	18/35 (51%)
		WD40 repeat	398..434	CDD:293791	16/35 (46%)
		WD40 repeat	441..476	CDD:293791	16/34 (47%)
		WD40 repeat	482..519	CDD:293791	11/37 (30%)
		WD40 repeat	525..551	CDD:293791	11/25 (44%)
rna4	NP_592966.1	SFM	48..92	CDD:128776	16/43 (37%)
		WD40	<170..460	CDD:441893	113/293 (39%)
		WD40 repeat	178..212	CDD:293791	8/33 (24%)
		WD40 repeat	218..263	CDD:293791	11/45 (24%)
		WD40 repeat	268..304	CDD:293791	18/35 (51%)
		WD40 repeat	311..346	CDD:293791	16/34 (47%)
		WD40 repeat	352..384	CDD:293791	15/31 (48%)
		WD40 repeat	394..432	CDD:293791	11/37 (30%)
		WD40 repeat	438..460	CDD:293791	9/23 (39%)