Protein Alignment U4-U6-60K and prp-4

DIOPT Version :10

• Sequence 1: NP_648990.1
• Gene: U4-U6-60K / 39955
• FlyBaseID: FBgn0036733
• Length: 553
• Species: Drosophila melanogaster
• Sequence 2: NP_492363.1
• Gene: prp-4 / 183250
• WormBaseID: WBGene00007972
• Length: 496
• Species: Caenorhabditis elegans
• Alignment Length: 486
• Identity: 212/486 - (43%)
• Similarity: 303/486 - (62%)
• Gaps: 23/486 - (4%)

  Fly    72 ESTKKTSNAKQAGAPPPTA---ATLANKIDDDYFDLEMEMERDKVALLEEFERKKRARQINVSTD 133
            ||.....||:|....|..:   ..::|:.|..: |.||         ..||:|::|||.:.:.||
 Worm    23 ESVNAILNAQQQNHGPTVSLERMEVSNQADSRH-DAEM---------FAEFDRRRRARTLTLPTD 77

  Fly   134 DTEIKSNLRQLNEPICYFGEGPAERRRRLKELLAGLGENAINKRQYEDEERKQQQREQDQATWYH 198
            |.::|..||.||:|||.|||...:||.||:.||:.:.|:.|....:.||. ...:.:::..||||
 Worm    78 DVQVKLKLRALNQPICLFGEDALDRRERLRALLSTMSEDEIAAVLHTDEV-NADKADEETVTWYH 141

  Fly   199 EGPDSLRIARLWLADYSLPRAKDRLVRAREALEVPSAARAGRMVEMQKKLQSLAPLCSQVGDTRP 263
            .||..||:||:.:||:||.:||.||.:|||....|:..:|....|..|.:|.:....|||.||||
 Worm   142 RGPIELRMARVSIADFSLRKAKLRLDKAREEAARPAHEKALARQEAHKWVQQINLHASQVADTRP 206

  Fly   264 VSSAAFSEDSSLLLTSSWSGLCKLWSVPDCELKQTLRGHASYVGGVALRPGVKADEE----NVVA 324
            |:...||.||..::|:.|||...:|....|..:....||:|..|.....||.....:    |||
 Worm   207 VAFCEFSADSEHIVTAGWSGSVAVWKREQCAQEIKFIGHSSQAGCARFHPGAFTQNDYSSLNVV- 270

  Fly   325 MASGGHDGAVKLWGFNNEESIADITGHMPHRVSKVAFHPSGRFLATACYDSSWRLWDLEQKTEVL 389
              |..:||.|.||..:.|..|.::..| |.|||||||||:|..|||||:||:||::||..|.|:|
 Worm   271 --SCSYDGTVLLWSLSQESPIGELEQH-PQRVSKVAFHPNGHHLATACFDSTWRMYDLTTKKELL 332

  Fly   390 HQEGHAKPVHCLSYHSDGSVLVTGGLDAFGRVWDLRTGRCIMFLEGHLGAVFGVDFSPNGFHIAT 454
            :||||:|.|..:::|.||||.:|||.|.:|||||:|||||||||:||...:..|::.|||:.:.|
 Worm   333 YQEGHSKSVADVAFHPDGSVALTGGHDCYGRVWDMRTGRCIMFLDGHTKEIHSVEWMPNGYEMIT 397

  Fly   455 GSQDNTCKIWDLRRRQPVYTIPAHTNLISDVKYQQECGSFLVTCSYDSTTKIWSNKTWQPLKTLQ 519
            ||.||:.|:||||.|:..||:||||::::.|: ....|.:||:.|:|.|.|:||...||||:.||
 Worm   398 GSSDNSMKVWDLRMRRNTYTMPAHTSVVTRVR-ADAAGQYLVSASFDCTLKMWSTTGWQPLRQLQ 461

  Fly   520 GHDNKVISVDIAPNSQYIATTSFDRTFKLWS 550
            |||.:::.|||:|:.|::.:::||||||||:
 Worm   462 GHDTRILCVDISPDGQWMCSSAFDRTFKLWA 492

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
U4-U6-60K	NP_648990.1	CCDC66	<113..>194	CDD:434558	30/80 (38%)
		SFM	132..>166	CDD:128776	18/33 (55%)
		WD40 repeat	264..301	CDD:293791	11/36 (31%)
		WD40	<286..553	CDD:441893	129/269 (48%)
		WD40 repeat	357..393	CDD:293791	23/35 (66%)
		WD40 repeat	398..434	CDD:293791	23/35 (66%)
		WD40 repeat	441..476	CDD:293791	17/34 (50%)
		WD40 repeat	482..519	CDD:293791	14/36 (39%)
		WD40 repeat	525..551	CDD:293791	13/26 (50%)
prp-4	NP_492363.1	SFM	76..115	CDD:128776	20/38 (53%)
		WD40	191..492	CDD:238121	145/305 (48%)
		WD40 repeat	207..244	CDD:293791	11/36 (31%)
		WD40 repeat	250..294	CDD:293791	14/46 (30%)
		WD40 repeat	299..335	CDD:293791	23/35 (66%)
		WD40 repeat	342..377	CDD:293791	22/34 (65%)
		WD40 repeat	383..419	CDD:293791	17/35 (49%)
		WD40 repeat	425..461	CDD:293791	14/36 (39%)
		WD40 repeat	467..491	CDD:293791	11/23 (48%)