DRSC/TRiP Functional Genomics Resources

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Protein Alignment U4-U6-60K and DAW1

DIOPT Version :9

Sequence 1:NP_648990.1 Gene:U4-U6-60K / 39955 FlyBaseID:FBgn0036733 Length:553 Species:Drosophila melanogaster
Sequence 2:NP_849143.1 Gene:DAW1 / 164781 HGNCID:26383 Length:415 Species:Homo sapiens


Alignment Length:289 Identity:87/289 - (30%)
Similarity:139/289 - (48%) Gaps:12/289 - (4%)


- Green bases have known domain annotations that are detailed below.


  Fly   263 PVSSAAFSEDSSLLLTSSWSGLCKLWSVPDCELKQTLRGHASYVGGVALRP--GVKADEENVVAM 325
            |:::.|.::..|..:|.|:...||||.....|...||.||.:.|..:|...  |.|        :
Human    94 PLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPYGDK--------I 150

  Fly   326 ASGGHDGAVKLWGFNNEESIADITGHMPHRVSKVAFHPSGRFLATACYDSSWRLWDLEQKTEVLH 390
            |:|..|...|||.....:......||....|. ::|:|....:||...|::.:|||::...||..
Human   151 ATGSFDKTCKLWSVETGKCYHTFRGHTAEIVC-LSFNPQSTLVATGSMDTTAKLWDIQNGEEVYT 214

  Fly   391 QEGHAKPVHCLSYHSDGSVLVTGGLDAFGRVWDLRTGRCIMFLEGHLGAVFGVDFSPNGFHIATG 455
            ..||:..:..||:::.|..::||..|....|||..|||.:..|.||...:....|:.:...|.||
Human   215 LRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCSLILTG 279

  Fly   456 SQDNTCKIWDLRRRQPVYTIPAHTNLISDVKYQQECGSFLVTCSYDSTTKIWSNKTWQPLKTLQG 520
            |.|.|||:||....:.|.|:..|.:.|.|..:.. .|..:.|.|.|.|.:|:|..|.:.:..|:|
Human   280 SMDKTCKLWDATNGKCVATLTGHDDEILDSCFDY-TGKLIATASADGTARIFSAATRKCIAKLEG 343

  Fly   521 HDNKVISVDIAPNSQYIATTSFDRTFKLW 549
            |:.::..:...|...::.|.|.|:|.::|
Human   344 HEGEISKISFNPQGNHLLTGSSDKTARIW 372

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
U4-U6-60KNP_648990.1 SFM 132..>166 CDD:128776
WD40 repeat 264..301 CDD:293791 11/36 (31%)
WD40 <286..553 CDD:225201 81/266 (30%)
WD40 286..550 CDD:238121 81/266 (30%)
WD40 repeat 357..393 CDD:293791 10/35 (29%)
WD40 repeat 398..434 CDD:293791 12/35 (34%)
WD40 repeat 441..476 CDD:293791 13/34 (38%)
WD40 repeat 482..519 CDD:293791 10/36 (28%)
WD40 repeat 525..551 CDD:293791 6/25 (24%)
DAW1NP_849143.1 eRF1 <22..>90 CDD:224420
WD40 81..120 CDD:197651 8/25 (32%)
WD 1 90..129 10/34 (29%)
WD40 repeat 96..132 CDD:293791 11/35 (31%)
WD40 126..415 CDD:238121 77/257 (30%)
WD 2 132..174 12/49 (24%)
WD40 repeat 137..175 CDD:293791 10/45 (22%)
WD 3 175..214 13/39 (33%)
WD40 repeat 181..217 CDD:293791 11/36 (31%)
WD 4 217..256 14/38 (37%)
WD40 repeat 222..258 CDD:293791 12/35 (34%)
WD 5 259..298 14/38 (37%)
WD40 repeat 265..300 CDD:293791 13/34 (38%)
WD 6 301..340 11/39 (28%)
WD40 repeat 306..342 CDD:293791 10/36 (28%)
WD 7 343..384 8/30 (27%)
WD40 repeat 348..384 CDD:293791 6/25 (24%)
WD 8 386..415
WD40 repeat 390..414 CDD:293791
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0272
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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