Protein Alignment Oatp74D and Slco1a6

DIOPT Version :10

• Sequence 1: NP_648989.1
• Gene: Oatp74D / 39954
• FlyBaseID: FBgn0036732
• Length: 819
• Species: Drosophila melanogaster
• Sequence 2: XP_063142836.1
• Gene: Slco1a6 / 84608
• RGDID: 69304
• Length: 690
• Species: Rattus norvegicus
• Alignment Length: 685
• Identity: 192/685 - (28%)
• Similarity: 317/685 - (46%)
• Gaps: 98/685 - (14%)

  Fly   146 NGG--SSAESSSS------------CGLFGCRPRWARRFASTHVFMVVFLLAYILQGMYMTYFVS 196
            :||  |.||:||:            .|..|     .|.||...||::....||..:.:..||..|
  Rat     3 DGGKASKAETSSTNQKNKMGEPEKRAGTHG-----IRCFAKIKVFLLALTWAYASKALSATYMNS 62

  Fly   197 VITTIEKLFQIKSKTTGILLSASEMGQICTAMLLTYFAGRGHRPRWIACGMVLFSIAAFSCALPH 261
            ::|.||:.|.|.:...|::..:.|:|.:...:.::||..:.|||..|..|..:..:..|..:|||
  Rat    63 MLTQIERRFNISTSIVGLINGSFEVGNLLLIIFVSYFGRKRHRPIMIGIGCAVMGLGCFIISLPH 127

  Fly   262 FIFGEQLMHSSVILQQTQVSPPNNSFSSHWLNASSEQVNPNLCILGGNQ----THSGSECNEERQ 322
            |:.|.       ...:|.:||.:|..|           |..||:....|    |...:||.:|.:
  Rat   128 FLMGR-------YEYETTISPTSNLSS-----------NSFLCMENRTQTLKPTQDPAECVKEMK 174

  Fly   323 LEQASHSKITVIVLCIFFGSLLSSGIGQTAVATLGIPYIDDNVGSKQSPMYMAVTIGMRILGPAS 387
                     :::.:.:..|::: .|||:|.:..|||.||:|...|:.||.|:.:....:|.||.:
  Rat   175 ---------SLMWIYVLVGNII-RGIGETPIMPLGISYIEDFAKSENSPFYIGILEVGKITGPIA 229

  Fly   388 GFIFGSFCTRWYVNFSNPGFD-----ATDPRWIGAWWLGPVAIGSLMLLASIAMFSFPKQLRGKQ 447
            ....||||...||:..:...|     .||.|.:||||:|.:....|.:|.||..|.|||.. .|:
  Rat   230 AIWLGSFCATIYVDMGSVNTDDLTITPTDTRCVGAWWIGFLVCAGLNILISIPFFFFPKTF-PKE 293

  Fly   448 KPPGQTATPAAPVEPEEKPKLKDFPKTVRRQLSNDILMF-RTASC-----------VFHLLPIAG 500
            .|...    |...:.:|..|.::..|..:|.::.|..:| ::.||           |..:.....
  Rat   294 GPEDM----ANETKNDEGDKHREKAKEEKRGITKDFFLFMKSLSCNPIYMLCVLTSVLQVNGFVS 354

  Fly   501 LYTFLPKYLETQFRLATYDANMIAAFCGILVMGIGIVISGLFILKRKPTARGVAAWIAFTALVYS 565
            ::||.|||||..:..::.:|..:.....:..:.:|.:||| ||:|:.......||:|:     |.
  Rat   355 IFTFKPKYLEHHYGKSSSEAIFLMGLYTLPSVCVGYLISG-FIMKKFKITLKKAAFIS-----YC 413

  Fly   566 AGM------IILMFIGCSMNDFAGYKPS-DGNSPAL-IEPTCSAALN--CTCDKENFAPICAD-G 619
            .||      :....:.|.....||...| :|...:. :|.|..|..|  |:|..:.:.|:|.| |
  Rat   414 LGMSECLLSLCNFMLTCDNVPIAGLTTSYEGIQQSFDMENTVLADCNTRCSCLTKTWDPVCGDNG 478

  Fly   620 KMYISACHAGCSSSSLRPSDNRTLYSDCACIPDA--PEAVNGYCDN--NCKNFI-YFILIFAICV 679
            ..||:.|.|||..|.  .|....:..||:||..:  ..||.|.|:.  :|.|.: ||::|...|.
  Rat   479 LAYITPCLAGCEKSV--GSGINMVLQDCSCIQSSGNSSAVLGLCNKGPDCANKLQYFLIITVFCS 541

  Fly   680 FMHSTSEVGSMLLVMRCTHPKDKAMAMGVIQSAIGLFGNVPCPIIYGAVVDSACLIW-KSVCGKH 743
            |.:|.|.:...::.:||...::|::.:|:....:.:.|.:..||.:|.::|..||.| ...||:.
  Rat   542 FFYSLSLIPGYMIFLRCMKSEEKSLGIGLQAFCMRILGGILAPIYFGVLIDRTCLHWGTQKCGEP 606

  Fly   744 GACSLYDADTFRQYFLGITAGIMFLAFLMDLVVWR 778
            |||..|:.::||..:||:.|.:...::|....:.|
  Rat   607 GACRTYEINSFRSIYLGLPAALRGSSYLPAFFILR 641

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Oatp74D	NP_648989.1	OATP	175..754	CDD:460821	173/616 (28%)
Slco1a6	XP_063142836.1	None