Protein Alignment Oatp74D and Slco1a5

DIOPT Version :10

• Sequence 1: NP_648989.1
• Gene: Oatp74D / 39954
• FlyBaseID: FBgn0036732
• Length: 819
• Species: Drosophila melanogaster
• Sequence 2: NP_110465.1
• Gene: Slco1a5 / 80900
• RGDID: 70985
• Length: 670
• Species: Rattus norvegicus
• Alignment Length: 693
• Identity: 201/693 - (29%)
• Similarity: 339/693 - (48%)
• Gaps: 93/693 - (13%)

  Fly   168 RRFASTHVFMVVFLLAYI---LQGMYMTYFVSVITTIEKLFQIKSKTTGILLSASEMGQICTAML 229
            |.|:...:|::....||:   |.|:||.   :::|.||:.|.|.:...|.:..:.|:|.:...:.
  Rat    14 RCFSKIKMFLLALTWAYVSKSLSGIYMN---TMLTQIERQFDIPTSIVGFINGSFEIGNLLLIIF 75

  Fly   230 LTYFAGRGHRPRWIACGMVLFSIAAFSCALPHFIFGEQLMHSSVILQQTQVSPPNNSFSSHWLNA 294
            ::||..:.|||..|..|.|:..:..|..:||||:.|.       ...:|.:||.:|..|
  Rat    76 VSYFGTKLHRPIMIGVGCVIMGLGCFLMSLPHFLMGR-------YEYETTISPTSNLSS------ 127

  Fly   295 SSEQVNPNLCILGGNQ----THSGSECNEERQLEQASHSKITVIVLCIFFGSLLSSGIGQTAVAT 355
                 |..||:...:|    |...:||.:|.:         :::.:.:..|::: .|||:|.:..
  Rat   128 -----NSFLCMENRSQTLKPTQDPAECIKEMK---------SLMWIYVLVGNII-RGIGETPIMP 177

  Fly   356 LGIPYIDDNVGSKQSPMYMAVTIGMRILGPASGFIFGSFCTRWYVNFSNPGFD-----ATDPRWI 415
            |||.||:|...|:.||:|:.:....::.||..|.:.||||...||:..:...|     .||.||:
  Rat   178 LGISYIEDFAKSENSPLYIGILETGKVFGPIVGLLLGSFCASIYVDTGSVNTDDLTITPTDTRWV 242

  Fly   416 GAWWLGPVAIGSLMLLASIAMFSFPKQL--RGKQKPPGQTATPAAPVEPEEKPKLKDFPKTVRRQ 478
            ||||:|.:....:.:|:||..|.|||.|  .|.|.....|..     :.|||.:.|  .|...|.
  Rat   243 GAWWIGFLICAGVNILSSIPFFFFPKTLPKEGLQDDVDGTNN-----DKEEKHREK--AKEENRG 300

  Fly   479 LSNDILMF-RTASC--VFHLLPIA---------GLYTFLPKYLETQFRLATYDANMIAAFCGILV 531
            ::.|.|.| ::.||  ::.||.:.         .::||||||||.|:..:|.:..::.....:..
  Rat   301 ITKDFLPFMKSLSCNPIYMLLILTSVLQINAFINMFTFLPKYLEQQYGKSTAEVVLLIGVYNLPP 365

  Fly   532 MGIGIVISGLFILKRKPTARGVAAWIAFTALVYSAGMIILMF-IGCSMNDFAGYKPS-DG-NSPA 593
            :.||.::.|..:.|.|.|.: .||::||...::...:..|.| |.|.....||...| :| :.|.
  Rat   366 ICIGYLLIGFIMKKFKITVK-KAAYMAFCLSLFEYLLYFLHFMITCDNFPVAGLTASYEGVHHPL 429

  Fly   594 LIEPTCSAALN--CTCDKENFAPICAD-GKMYISACHAGCSSSSLRPSDNRTLYSDCACIPDA-- 653
            .:|....|..|  |:|...::.|:|.| |..|:|||.|||..|.  .:....::.:|:||..:
  Rat   430 YVENKVLADCNRGCSCSTNSWDPVCGDNGLAYMSACLAGCKKSV--GTGTNMVFQNCSCIRSSGN 492

  Fly   654 PEAVNGYCDN--NCKNFI-YFILIFAICVFMHSTSEVGSMLLVMRCTHPKDKAMAMGVIQSAIGL 715
            ..||.|.|..  .|.|.: ||:::..|..|::|.:.:...::::||..|::|::.:|:......:
  Rat   493 SSAVLGLCKKGPECANKLQYFLIMSVIGSFIYSITAIPGYMVLLRCIKPEEKSLGIGLHAFCTRV 557

  Fly   716 FGNVPCPIIYGAVVDSACLIWKSV-CGKHGACSLYDADTFRQYFLGITA---GIMFLAFLMDLVV 776
            |..:|.||.:||::|..||.|.:: ||:.|||.:|:.:.||:.:|.:.|   |..:|..|..|::
  Rat   558 FAGIPAPIYFGALIDRTCLHWGTLKCGEPGACRMYNINNFRRIYLVLPAALRGSSYLPALFILIL 622

  Fly   777 WRKAHRIDIAPEDPQEGGPASNGRTLEVSESKQPITPAPDTTV 819
            .||.          |..|...:..| |::|.|..:..:..|.|
  Rat   623 MRKF----------QFPGEIDSSET-ELAEMKITVKKSECTDV 654

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Oatp74D	NP_648989.1	OATP	175..754	CDD:460821	181/616 (29%)
Slco1a5	NP_110465.1	oat	1..625	CDD:273279	191/651 (29%)