Protein Alignment Oatp74D and Slco1a8

DIOPT Version :10

• Sequence 1: NP_648989.1
• Gene: Oatp74D / 39954
• FlyBaseID: FBgn0036732
• Length: 819
• Species: Drosophila melanogaster
• Sequence 2: NP_110464.2
• Gene: Slco1a8 / 80899
• RGDID: 621387
• Length: 670
• Species: Rattus norvegicus
• Alignment Length: 702
• Identity: 191/702 - (27%)
• Similarity: 334/702 - (47%)
• Gaps: 98/702 - (13%)

  Fly   144 DLNGGSSAESSSSCGLFGCRPRWARRFASTHVFMVVFLLAYILQGMYMTYFVSVITTIEKLFQIK 208
            ||..|::...:      ||       ||...||::....||:.:.:..|:..|::|.||:.|.|.
  Rat     3 DLEKGAATHGA------GC-------FAKIKVFLMALTCAYVSKSLSGTFMSSMLTQIERQFGIP 54

  Fly   209 SKTTGILLSASEMGQICTAMLLTYFAGRGHRPRWIACGMVLFSIAAFSCALPHFIFGEQLMHSSV 273
            :...|.:..:.|:|.:...:.::||..:.|||..|..|..:..:..|..:||||:.|.....:::
  Rat    55 TAIVGFINGSFEIGNLLLIIFVSYFGMKLHRPIVIGVGCAVMGLGCFIISLPHFLMGRYEYETTI 119

  Fly   274 ILQQTQVSPPNNSFSSHWLNASSEQVNPNLCILGGNQT----HSGSECNEERQLEQASHSKITVI 334
            :        |.::.||          |..||:....||    ...:||.:|.:         :::
  Rat   120 L--------PTSNLSS----------NSFLCMENQTQTLNPAQDPAECVKEVK---------SLM 157

  Fly   335 VLCIFFGSLLSSGIGQTAVATLGIPYIDDNVGSKQSPMYMAVTIGMRILGPASGFIFGSFCTRWY 399
            .:.:..|::: .|||:|.:..||:.||::...|:.||:|:.:....:::||..|.:.||||...|
  Rat   158 WIYVLVGNII-RGIGETPIMPLGVSYIENFAKSENSPLYIGILETGKMIGPIFGLLLGSFCASIY 221

  Fly   400 VNFSNPGFD-----ATDPRWIGAWWLGPVAIGSLMLLASIAMFSFPKQL--RGKQKPPGQTATPA 457
            |:..:...|     .||.||:||||:|.:....:.:|.||..|.|||.|  .|.|:....|
  Rat   222 VDTGSVNTDDLTITPTDIRWVGAWWIGFLVCAGVNILISIPFFFFPKTLPKEGLQENVDGT---- 282

  Fly   458 APVEPEEKPKLKDFPKTVRRQLSNDILMF-RTASC-----VFHLLPIAGL------YTFLPKYLE 510
               |..::.|.::..|..:|.::.|...| ::.||     :|.|:.:..:      ::|||||||
  Rat   283 ---ENAKEEKHREKAKEEKRGITKDFFPFLKSLSCNPIYMLFTLISVLQVNAFNIYFSFLPKYLE 344

  Fly   511 TQFRLATYDANMIAAFCGILVMGIGIVISGLFILKRKPTARGVAAWIAFTALV--YSAGMIILMF 573
            .|:..:|.:...:.....:..:.||.:|:|..:.|.|.|.: .||::||...:  ||.|....:
  Rat   345 NQYGKSTAEVIFLMGVYNLPAICIGYLIAGFMMKKFKITVK-TAAFLAFCLSLSEYSFGFCNFL- 407

  Fly   574 IGCSMNDFAGYKPS--DGNSPALIEPTCSAALN--CTCDKENFAPICAD-GKMYISACHAGCSSS 633
            |.|.....||...|  ....|..:|....|..|  |:|..:.:.|:|.| |..|:|||.|||..|
  Rat   408 ITCDNVPVAGLTNSYERDQKPLYLENNVLADCNTRCSCLTKTWDPVCGDNGLAYMSACLAGCEKS 472

  Fly   634 SLRPSDNRTLYSDCACI--PDAPEAVNGYCDN--NCKNFIYFILIFA-ICVFMHSTSEVGSMLLV 693
            .  .:....::.:|:||  |....||.|.|:.  .|.|.:.::||.: ....::|.:.:...::.
  Rat   473 V--GTGTNMVFHNCSCIQSPGNSSAVLGLCNKGPECTNKLQYLLILSGFLSILYSFAAIPGYMVF 535

  Fly   694 MRCTHPKDKAMAMGVIQSAIGLFGNVPCPIIYGAVVDSACLIW-KSVCGKHGACSLYDADTFRQY 757
            :||...::|::.:|:....|.:|..:|.||.:||::|..||.| ...||..|||.:||.::||:.
  Rat   536 LRCIKSEEKSLGIGIHAFCIRVFAGIPAPIYFGALIDRTCLHWGTQKCGAPGACRMYDINSFRRI 600

  Fly   758 FLGITAGIMFLAFLMDLVVWRKAHRIDIAPEDPQEGGPAS-NGRTLEVSESK 808
            :||::|.:...::|...|:.....:..:         |.. |...:|::|.|
  Rat   601 YLGMSAALRGSSYLPAFVIVILTRKFSL---------PGKINSSEMEIAEMK 643

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Oatp74D	NP_648989.1	OATP	175..754	CDD:460821	172/614 (28%)
Slco1a8	NP_110464.2	oat	1..625	CDD:273279	186/673 (28%)