Protein Alignment Oatp74D and slco2b1

DIOPT Version :10

• Sequence 1: NP_648989.1
• Gene: Oatp74D / 39954
• FlyBaseID: FBgn0036732
• Length: 819
• Species: Drosophila melanogaster
• Sequence 2: NP_001032767.2
• Gene: slco2b1 / 792084
• ZFINID: ZDB-GENE-051023-6
• Length: 677
• Species: Danio rerio
• Alignment Length: 675
• Identity: 194/675 - (28%)
• Similarity: 303/675 - (44%)
• Gaps: 110/675 - (16%)

  Fly   150 SAESSSSCGLFGCRPRWARRFASTHVFMVVFLLAYILQGMYMTYFVSVITTIEKLFQIKSKTTGI 214
            :|....|.|||.          :...|::...:..:.|.:...|..:.||||||.:...|..:|:
Zfish    12 TARPRRSMGLFN----------NIKFFVLCHGMLQLSQLLVSGYLKASITTIEKRYGFSSSKSGL 66

  Fly   215 LLSASEMGQICTAMLLTYFAGRGHRPRWIACGMVLFSIAAFSCALPHFIFGEQLMHSSVILQQTQ 279
            |.:.:|:|.....:.:::|..|.||||.|..|.::.|:..|..|||||| .|:..::..|
Zfish    67 LAAFNEVGNTVLIVFVSFFGSRVHRPRCIGIGGMIASMGVFLIALPHFI-SEKYEYTEFI----- 125

  Fly   280 VSPPNNSFSSHWLNASSEQVNPNLCILGGNQT---HSGSECNEERQLEQASHSKITVIVLCIFFG 341
                           |:.::|.:||     ||   .|...|::.....|..      :...:..|
Zfish   126 ---------------SNTRLNSSLC-----QTQDIESSPTCSQNDTDPQLG------VYPILLLG 164

  Fly   342 SLLSSGIGQTAVATLGIPYIDDNVGSKQSPMYMAVTIGMRILGPASGFIFGSFCTRWYVNFSNPG 406
            .|| .|||...:...||.||||....:.||.|:.:...:.::|||.|:|..|...|.||:.....
Zfish   165 QLL-LGIGGVPIQPFGISYIDDYAERRNSPFYLGILFAVTVIGPAFGYIMSSAVLRLYVDIDKMS 228

  Fly   407 FDAT-----DPRWIGAWWLGPVAIGSLMLLASIAMFSFPKQLRGKQKPPGQTATPAAPVEP---- 462
            .:..     |||||||||||.:...:|:.|.|:....||:::..::       ...|||||
Zfish   229 LNENKLEHGDPRWIGAWWLGFLIAATLLSLTSLPYLFFPRKMSKEE-------IEEAPVEPSTEK 286

  Fly   463 ---EEKPK------------LKDFPKTVRRQLSNDILMFRTASCVFHLLPIAGLYTFLPKYLETQ 512
               .:||:            ||.||..|.|.|.|.|.:....:.|.....:|||.||:.|::|.|
Zfish   287 MIQNKKPETDQIEEVSLTQFLKSFPTIVLRTLRNPIYLLVVFAQVNLAAMVAGLATFMGKFIEKQ 351

  Fly   513 FRLATYDANMIAAFCGILVMGI-------GIVISGLFILKRKPTARGVAAWIAFTALVYSAGMII 570
            |.       ..|:|..|::.||       ||:..|:.:.:...|.|..||.......:.....|.
Zfish   352 FA-------RTASFSNIMMGGINIPSAMFGIMAGGVILRRLGLTVRSSAAMCTIAVFISIMFAIP 409

  Fly   571 LMFIGCSMNDFAGYKPSDGNSPALIEPTCSAALNCTCDKENFAPIC-ADGKMYISACHAGCSSSS 634
            |:||||.....:|....|...       ||.  :|.|..|.|.|:| :||..:.|.|||||...:
Zfish   410 LLFIGCPTQKISGLNYRDSQQ-------CSN--SCYCSDEAFNPVCGSDGVEFRSPCHAGCKIVN 465

  Fly   635 LRPSD--NRTLYSDCACIPDAPE---AVNGYCDNNCKN-FIYFILIFAICVFMHSTSEVGSMLLV 693
            ::...  ....|:||.|:..:..   |..|.|.:.|.| .|.|:::.::..|:.|.|...|.:::
Zfish   466 IKTIGRIQNVTYTDCGCVKSSGSPGFAFAGPCASGCSNLLIPFMILSSLTCFVASLSHTTSFMMI 530

  Fly   694 MRCTHPKDKAMAMGVIQSAIGLFGNVPCPIIYGAVVDSACLIWKSVCGKHGACSLYDADTFRQYF 758
            :|...|:||:.|:|:......:...:|.|::||..:|:|||:|...|.|..:|..|:.|.||..|
Zfish   531 LRTVTPEDKSFAVGIQFMLFRVLAFLPSPVLYGTAIDTACLVWGKKCSKSTSCLYYNLDLFRHRF 595

  Fly   759 LGITAGIM---FLAFLMDLVVWRKA 780
            ||:....:   |:.||:..:|.|:|
Zfish   596 LGLQIFFICGGFVCFLLSFLVLRRA 620

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Oatp74D	NP_648989.1	OATP	175..754	CDD:460821	178/619 (29%)
slco2b1	NP_001032767.2	MFS_SLCO2B_OATP2B	25..532	CDD:341018	158/562 (28%)