DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Oatp74D and Slco6c1

DIOPT Version :9

Sequence 1:	NP_001163460.1	Gene:	Oatp74D / 39954	FlyBaseID:	FBgn0036732	Length:	819	Species:	Drosophila melanogaster
Sequence 2:	NP_083218.1	Gene:	Slco6c1 / 74441	MGIID:	1921691	Length:	706	Species:	Mus musculus

Alignment Length:	744	Identity:	169/744 - (22%)
Similarity:	297/744 - (39%)	Gaps:	151/744 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   128 KLPPRSSESEESDFDSDLNGGSSAE--------SSSSCGLFGCRP---RWARRFASTHVFMVVFL 181
            |||.|....            :|||        |:|..|..|..|   .:.:||.:...||.:::
Mouse    49 KLPKRKKSP------------TSAELLLIDPRYSASKEGPLGLGPIVLPFVQRFNNIDGFMTLYV 101

  Fly   182 LAYILQGMYMTYFVSVITTIEKLFQIK---SKTTGILLSASE-MGQICTAMLLTYFAGRGHRPRW 242
            .|.::.|   ..|..|..|: .::|::   ::|...|:..|: :.....|:::.:|..:|:|.||
Mouse   102 AAVLIHG---ALFAVVDMTL-NIYQVQFSLTRTEWYLMDFSDYIASFVVAIIIAHFGSKGNRTRW 162

  Fly   243 IACGMVLFSIAAFSCALPHFIFGEQLMHSSVILQQTQVSPPNNSFSSHWLNASSEQVNPNLCILG 307
            ||...:|..:.:...|.|.|.:       .:|:      |...|.              .||:
Mouse   163 IAASCILMGLESMLFAFPFFTY-------EIII------PGRQSI--------------ELCM-- 198

  Fly   308 GNQTHSGSECNEERQL----EQASHSKITVIVLCIFF---GSLLSSGIGQTAVATLGIPYIDDNV 365
                    |.||:|.:    ...:.||      ||:|   |..: .||....:..|||.:|.|::
Mouse   199 --------EENEKRNIICGNSVPNRSK------CIYFHIAGQCI-HGIAGMPIYILGITFIFDHI 248

  Fly   366 GSKQSPMYMAVTIGMRILGPASGFIFGSFCTRWYVNFSNPGFDAT---DPRWI-----GAWWLGP 422
            .:.....|:|:.....::|...|.:.|      ..||..|..:.|   :|..:     ..||...
Mouse   249 PTSSCGFYLAIGHSAYLIGYLLGMVGG------LQNFQPPPKEKTVEIEPAKVYQLLQSGWWKTF 307

  Fly   423 VAIGSLMLLASIAMFSFPKQLRG-------KQKPPGQTATPAAPV------EPEEKPKLKDFPKT 474
            :.|.::....|..|..||..|.|       |:|.|        |.      :.:.:|.||.|...
Mouse   308 LIIAAISFCVSFMMVCFPTSLPGAHKLRLAKRKEP--------PTIDRRLKDMKIQPHLKGFLHN 364

  Fly   475 VRRQLSNDILMFRTASCVFHLLPIAGLYTFLPKYLETQFRLATYDANMIAAFCGILVMGIGIV-- 537
            :...|.|.:::.:....|...|.......|||.:|:|||.:....|:::.   |..|:..||:
Mouse   365 IWHILKNPLMLTQAICKVSEYLTFNTSLYFLPHHLQTQFLITPGIASLLT---GAFVLPGGIIGH 426

  Fly   538 -ISGLFILKRKPTARGVAAWIAFTALVYSAGMIILM-FIGCSMNDFAGYKPSDGNSPALIEPTCS 600
             :.||.:.:.:.|.:....:...|.:| |.|:.:|: |:.|....|||..........|...|..
Mouse   427 FLGGLIVDRLEMTNKNKLKFTLVTTVV-SVGLFLLIFFVECQTTTFAGINEDYDGYGQLGNLTAD 490

  Fly   601 AALNCTCDKENFAPICA-DGKMYISACHAGCSSSSLRPSDNRTLYSDCACIPDA----------P 654
            ....|.|....:..||. |.|.|.|.|.|||.::.:  |.....|.:|:||.:.          .
Mouse   491 CNEYCDCTTSLYTSICGRDEKEYFSPCFAGCKATKV--SQTEKTYYNCSCIKEGLAASDDEGQFI 553

  Fly   655 EAVNGYCDNNC-KNFIYFILIFAICVFMHSTSEVGSMLLVMRCTHPKDKAMAMGVIQSAIGLFGN 718
            :|:.|.||::| |..::|...|:..||.:..| :..:.::::.......::::||..:.:....:
Mouse   554 DAIAGTCDSDCLKLPLFFAFYFSATVFSNMCS-IPVISIILQSVPANFTSLSLGVTYAIVKFVAS 617

  Fly   719 VPCPIIYGAVVDSACLIW-KSVCGKHGACSLYDADTFRQYFLGITAGIMFLAFLMDLVVWRKAHR 782
            ||.|:::......||:.| .:.||....|.:|:.:.....|:||......:..|:::      :.
Mouse   618 VPAPLLFRLSSAIACIYWDNNRCGGKERCWIYNKNILVYEFMGIWMSSQLIIVLLNI------YA 676

  Fly   783 IDIAPEDPQEGGPASNGRTL--EVSESKQ 809
            |.|  .|....|..:..:|.  :|.|.|:
Mouse   677 IQI--HDVVVHGEITESKTTVKDVKEQKE 703

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oatp74D	NP_001163460.1	OATP	175..754	CDD:335235	143/627 (23%)
Slco6c1	NP_083218.1	OATP	95..654	CDD:281175	143/627 (23%)
		MFS	97..>463	CDD:119392	95/431 (22%)
		KAZAL_SLC21	487..540	CDD:238650	17/54 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3626
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810