DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Oatp74D and Slco6d1

DIOPT Version :9

Sequence 1:	NP_001163460.1	Gene:	Oatp74D / 39954	FlyBaseID:	FBgn0036732	Length:	819	Species:	Drosophila melanogaster
Sequence 2:	XP_011246380.1	Gene:	Slco6d1 / 70866	MGIID:	1918116	Length:	729	Species:	Mus musculus

Alignment Length:	716	Identity:	147/716 - (20%)
Similarity:	268/716 - (37%)	Gaps:	174/716 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   159 LFGCRPRWARRFASTHVFMVVFLLAYILQGMYMTYFVSVITTIEKLFQIK---SKTTGILLSASE 220
            :|.|    .:||.:...|:.:..||.:...|   .|..|..:| ||:..:   |:....|:..|:
Mouse    73 VFPC----LQRFNNVKSFLTLSFLAVVAHSM---IFALVDQSI-KLYVAQLSPSRIEEYLMDTSD 129

  Fly   221 -MGQICTAMLLTYFAGRGHRPRWIACGMVLFSIAAFSCALPHFIFGEQLMHSSVILQQTQVSPPN 284
             ......:|.:.:|.|||:|..|:|.|..|..|||...|:|...|  :::..||:.::
Mouse   130 NFVAFLFSMFVAHFGGRGNRANWVAAGCFLTGIAAIVFAVPFLNF--EIIKLSVVKEE------- 185

  Fly   285 NSFSSHWLNASSEQVNPNLCILGGNQTHSGSECNEERQLEQASHSKITVI---VLCIF---FGSL 343
                              ||              ||.:|.:....  ||:   .:|||   ||..
Mouse   186 ------------------LC--------------EEGKLPKVCEP--TVLPHKSICIFIFIFGQC 216

  Fly   344 LSSGIGQTAVATLGIPYIDDNVGSKQSPMYMAVTIGMRILGPASGFIFGSFCTRWYVNFSNPGFD 408
            | .||....:..|...:|.|:|.:..|.:|:|:......:|...|||.|      .:||.....:
Mouse   217 L-HGIAGLPLYILATSFIFDHVPTNSSGLYIALVDAALGVGYCLGFIGG------MLNFKMSAQE 274

  Fly   409 ATDPRWIG----------AWWLGPVAIGSLMLLASIAMFSFPKQLRGKQKPPGQTATPAAPVEPE 463
            ....  :|          .||...:.:.......::.:..||..|.|.::         ..:|..
Mouse   275 VMQA--VGHRQRIRILQRGWWRTFIFVAVFAFCTTLPLLGFPSSLPGARQ---------IRLEKS 328

  Fly   464 EKPKLKDFPKTVRRQLSNDILMFRTASCVFH---------------------------------- 494
            ::|...| .:...:::.|::.....|:.::|
Mouse   329 QEPPTFD-RRLKNKEIKNNLKSVLHATWIYHRGHLTILSQTCSTSLGGICCSTTGKAIDGDLQKL 392

  Fly   495 ----------LLPIAGLYT----------FLPKYLETQFRLATYDANMIAAFCGILVMG---IGI 536
                      |..:...:|          |||:||:|:|.:....|:|:.   |:.::.   .|.
Mouse   393 TQCLIRNPLVLSQVVCKFTEFTTFKSSAVFLPQYLQTRFLIRPSSASMLT---GVFILPGSIFGH 454

  Fly   537 VISGLFILKRKPTARGVAAWIAFTALVYSAGMIILMFIGCSMNDFAGYKPSDGNSPALIEPTCSA 601
            ...|..:.:.:...:....::...:.|.....::..|:.|.::.|||..........:...|...
Mouse   455 FFGGFIVHRMQMNNKNKLKFLVVASFVSIVLFLLTFFVECEISKFAGINDDYDRLGIIGNLTAPC 519

  Fly   602 ALNCTCDKENFAPICA-DGKMYISACHAGC-SSSSLRPSDNRTLYSDCACIPDA----------P 654
            .:.|.|....:.|:|. |...|.|.|.||| ::..||   ....|.:|:||.:.          .
Mouse   520 NVPCGCTTSEYNPVCGRDETQYFSPCFAGCKATKKLR---KEKTYYNCSCIKEGLTTADNEGQYI 581

  Fly   655 EAVNGYCDNNCKNFIYFILIFAICVFMHSTSEVGSMLLVMRCTHPKDKAMAMGVIQSAIGLFGNV 719
            :||:|.|:..|.....|...:....|:.|...:.|.|:|::.......:|::|::.:.....|:|
Mouse   582 DAVSGTCNTRCLTLPLFFAFYFTATFLSSFCSIPSALIVIQSVPTSWNSMSLGLMSTVWRFTGSV 646

  Fly   720 PCPIIYGAVVDSACLIWK-SVCGKHGACSLYDAD----TFRQYFLG--ITAGI--MFLAFLMDLV 775
            |.||::.|..|..|..|. :.||:...|.:|:.:    ||:..::.  |.:|:  ::..:..|.|
Mouse   647 PAPILFAATSDFTCQFWGINECGEKVRCWIYNTENLVYTFKTVWINMQILSGLSCLYGVYRHDYV 711

  Fly   776 V 776
            |
Mouse   712 V 712

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oatp74D	NP_001163460.1	OATP	175..754	CDD:335235	136/672 (20%)
Slco6d1	XP_011246380.1	MFS	83..622	CDD:391944	121/610 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3626
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810