Protein Alignment Oatp74D and SLCO1A2

DIOPT Version :10

• Sequence 1: NP_648989.1
• Gene: Oatp74D / 39954
• FlyBaseID: FBgn0036732
• Length: 819
• Species: Drosophila melanogaster
• Sequence 2: NP_066580.1
• Gene: SLCO1A2 / 6579
• HGNCID: 10956
• Length: 670
• Species: Homo sapiens
• Alignment Length: 683
• Identity: 196/683 - (28%)
• Similarity: 329/683 - (48%)
• Gaps: 95/683 - (13%)

  Fly   168 RRFASTHVFMVVFLLAYILQGMYMTYFVSVITTIEKLFQIKSKTTGILLSASEMGQICTAMLLTY 232
            |..:...:|::....|::.:.:..:|..|::|.||:.|.|.:...|.:..:.|:|.:...:.::|
Human    14 RCLSKLKMFLLAITCAFVSKTLSGSYMNSMLTQIERQFNIPTSLVGFINGSFEIGNLLLIIFVSY 78

  Fly   233 FAGRGHRPRWIACGMVLFSIAAFSCALPHFIFGEQLMHSSVILQQTQVSPPNNSFSSHWLNASSE 297
            |..:.|||..|..|.|:..:..|..:||||:..:....|:|.:.....|   |||
Human    79 FGTKLHRPIMIGIGCVVMGLGCFLKSLPHFLMNQYEYESTVSVSGNLSS---NSF---------- 130

  Fly   298 QVNPNLCILGGNQ----THSGSECNEERQLEQASHSKITVIVLCIFFGSLLSSGIGQTAVATLGI 358
                 ||:..|.|    |...|||.:|.:      |.:.|.||   .|::: .|:|:|.:..|||
Human   131 -----LCMENGTQILRPTQDPSECTKEVK------SLMWVYVL---VGNIV-RGMGETPILPLGI 180

  Fly   359 PYIDDNVGSKQSPMYMAVTIGMRILGPASGFIFGSFCTRWYVN--FSNPG---FDATDPRWIGAW 418
            .||:|....:.||:|:.:.....|:||..|.:..|||...||:  |.|..   ...||.||:|||
Human   181 SYIEDFAKFENSPLYIGLVETGAIIGPLIGLLLASFCANVYVDTGFVNTDDLIITPTDTRWVGAW 245

  Fly   419 WLGPVAIGSLMLLASIAMFSFPKQLRGKQKPPGQTATPAAPVEPEEKPKLKDFPKTVRRQLSNDI 483
            |.|.:....:.:|.:|..|..|..|     |.....|.|..::.|.:.|.|:..|..:..::.|.
Human   246 WFGFLICAGVNVLTAIPFFFLPNTL-----PKEGLETNADIIKNENEDKQKEEVKKEKYGITKDF 305

  Fly   484 LMF-RTASC-----VFHLLPI------AGLYTFLPKYLETQFRLATYDANMIAAFCGILVMGIGI 536
            |.| ::.||     :|.|:.:      ..:.:|:|||||.|:.:::.||..:.....:..:.||.
Human   306 LPFMKSLSCNPIYMLFILVSVIQFNAFVNMISFMPKYLEQQYGISSSDAIFLMGIYNLPPICIGY 370

  Fly   537 VISGLFILKRKPT---ARGVAAWIAFTALVYSAGMIILMFIG----CSMNDFAGYKPSDGNSP-- 592
            :|.||.:.|.|.|   |..:..|::.  |.|     :|.|:.    |..:...|...|....|
Human   371 IIGGLIMKKFKITVKQAAHIGCWLSL--LEY-----LLYFLSFLMTCENSSVVGINTSYEGIPQD 428

  Fly   593 ALIEPTCSAALN--CTCDKENFAPICA-DGKMYISACHAGCSSSSLRPSDNRTLYSDCACIPDA- 653
            ..:|....|..|  |.|..:.:.|:|. :|..|:|||.|||.:|.  .:....::.:|:||..:
Human   429 LYVENDIFADCNVDCNCPSKIWDPVCGNNGLSYLSACLAGCETSI--GTGINMVFQNCSCIQTSG 491

  Fly   654 -PEAVNGYCDN--NCKNFI-YFILIFAICVFMHSTSEVGSMLLVMRCTHPKDKAMAMGVIQSAIG 714
             ..||.|.||.  :|...: ||:::.|:..|::|.:.:...::::||...::|::.:|:......
Human   492 NSSAVLGLCDKGPDCSLMLQYFLILSAMSSFIYSLAAIPGYMVLLRCMKSEEKSLGVGLHTFCTR 556

  Fly   715 LFGNVPCPIIYGAVVDSACLIWKSV-CGKHGACSLYDADTFRQYFLGITA---GIMFLAFLMDLV 775
            :|..:|.||.:||::||.||.|.:: ||:.|||.:||:.|||..:||:.|   |..|:..|:.|:
Human   557 VFAGIPAPIYFGALMDSTCLHWGTLKCGESGACRIYDSTTFRYIYLGLPAALRGSSFVPALIILI 621

  Fly   776 VWRKAHRIDIAPEDPQEGGPASNGRTLEVSESK 808
            :.||.|         ..|..||:|  .|:.|:|
Human   622 LLRKCH---------LPGENASSG--TELIETK 643

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Oatp74D	NP_648989.1	OATP	175..754	CDD:460821	175/617 (28%)
SLCO1A2	NP_066580.1	oat	1..625	CDD:273279	186/652 (29%)