Protein Alignment Oatp74D and SLCO2A1

DIOPT Version :10

• Sequence 1: NP_648989.1
• Gene: Oatp74D / 39954
• FlyBaseID: FBgn0036732
• Length: 819
• Species: Drosophila melanogaster
• Sequence 2: NP_005621.2
• Gene: SLCO2A1 / 6578
• HGNCID: 10955
• Length: 643
• Species: Homo sapiens
• Alignment Length: 667
• Identity: 207/667 - (31%)
• Similarity: 324/667 - (48%)
• Gaps: 83/667 - (12%)

  Fly   148 GSSAESSSSCGLFGCRPRWARR-FASTHVFMVVFLLAYILQGMYMTYFVSVITTIEKLFQIKSKT 211
            |:|..|.:|....|   |.||. |.:..||::...|..:.|.:|..||.|.:|||||.|.:.|.:
Human     8 GASQGSDTSTSRAG---RCARSVFGNIKVFVLCQGLLQLCQLLYSAYFKSSLTTIEKRFGLSSSS 69

  Fly   212 TGILLSASEMGQICTAMLLTYFAGRGHRPRWIACGMVLFSIAAFSCALPHFIFGEQLMHSSVILQ 276
            :|::.|.:|:......:.::||..|.||||.|..|.:..:..||...||||:        |...|
Human    70 SGLISSLNEISNAILIIFVSYFGSRVHRPRLIGIGGLFLAAGAFILTLPHFL--------SEPYQ 126

  Fly   277 QTQVSPPNNS------FSSHWLNASSEQVNPNLCILGGNQTHSGSECNEERQLEQASHSKITVIV 335
            .|..|..|||      ...||     :.:.|:.|       ||   ..:..|.|.:|...:.|:
Human   127 YTLASTGNNSRLQAELCQKHW-----QDLPPSKC-------HS---TTQNPQKETSSMWGLMVV- 175

  Fly   336 LCIFFGSLLSSGIGQTAVATLGIPYIDDNVGSKQSPMYMAVTIGMRILGPASGFIFGSFCTRWYV 400
                  :.|.:|||...:...||.|:||......||:|:::...:.:.|||.|::.||...:.:|
Human   176 ------AQLLAGIGTVPIQPFGISYVDDFSEPSNSPLYISILFAISVFGPAFGYLLGSVMLQIFV 234

  Fly   401 NFSN---------PGFDATDPRWIGAWWLGPVAIGSLMLLASIAMFSFPKQLR-GKQKPPGQTAT 455
            ::..         ||    |||||||||||.:...:|::|.|...|.||:.:. |.::.|. ||.
Human   235 DYGRVNTAAVNLVPG----DPRWIGAWWLGLLISSALLVLTSFPFFFFPRAMPIGAKRAPA-TAD 294

  Fly   456 PAAPVEPEEKPK------LKDFPKTVRRQLSNDI-LMFRTASCVFHLLPIAGLYTFLPKYLETQF 513
            .|..:| |.|.:      :|.||....|.|.|.: ::...|.|.|..: ||||.|||.|:||.|:
Human   295 EARKLE-EAKSRGSLVDFIKRFPCIFLRLLMNSLFVLVVLAQCTFSSV-IAGLSTFLNKFLEKQY 357

  Fly   514 RLATYDANMIAAFCGILVMGIGIVISGLFILKRKPTARGVAAWIAFTALVYSAGMII---LMFIG 575
            ..:...||.:.....:....:|::..|: ::||...:......||.|.:..|  ||:   |.|:|
Human   358 GTSAAYANFLIGAVNLPAAALGMLFGGI-LMKRFVFSLQAIPRIATTIITIS--MILCVPLFFMG 419

  Fly   576 CSMNDFAG-YKPSDGNSPALIEPTCSAALNCTCDKENFAPICAD-GKMYISACHAGCSSSSLRPS 638
            ||....|. |.||..:|.....|.|..  :|:|....|.|:|.| |..|:|.||||||:.::..:
Human   420 CSTPTVAEVYPPSTSSSIHPQSPACRR--DCSCPDSIFHPVCGDNGIEYLSPCHAGCSNINMSSA 482

  Fly   639 DNRTL-YSDCACIP-DAPEAVNGYCDNNCKNFI---YFILIFAICVFMHSTSEVGSMLLVMRCTH 698
            .::.| |.:|:|:. .:..|..|.|...|.:|:   .|::.|...:...|.:.:  .::|:|..:
Human   483 TSKQLIYLNCSCVTGGSASAKTGSCPVPCAHFLLPAIFLISFVSLIACISHNPL--YMMVLRVVN 545

  Fly   699 PKDKAMAMGVIQSAIGLFGNVPCPIIYGAVVDSACLIWKSVC-GKHGACSLYDADTFRQYFLGIT 762
            .::|:.|:||....:.|...:|.|.:||..:|.:|:.|.|:| |:.|||:.||.|..|..:||:.
Human   546 QEEKSFAIGVQFLLMRLLAWLPSPALYGLTIDHSCIRWNSLCLGRRGACAYYDNDALRDRYLGLQ 610

  Fly   763 AGIMFLA-FLMDLVVWR 778
            .|...|. .|:..:.||
Human   611 MGYKALGMLLLCFISWR 627

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Oatp74D	NP_648989.1	OATP	175..754	CDD:460821	190/612 (31%)
SLCO2A1	NP_005621.2	oat	1..630	CDD:273279	207/667 (31%)