Protein Alignment Oatp74D and Slco1b2

DIOPT Version :9

• Sequence 1: NP_001163460.1
• Gene: Oatp74D / 39954
• FlyBaseID: FBgn0036732
• Length: 819
• Species: Drosophila melanogaster
• Sequence 2: NP_113838.1
• Gene: Slco1b2 / 58978
• RGDID: 69300
• Length: 687
• Species: Rattus norvegicus
• Alignment Length: 691
• Identity: 190/691 - (27%)
• Similarity: 308/691 - (44%)
• Gaps: 69/691 - (9%)

  Fly   150 SAESSSSCGLFGCRPRWARRFASTHVFMVVFLLAYILQGMYMTYFVSVITTIEKLFQIKSKTTGI 214
            :||:..|      |.:..|......:|:.....:||.:.:......|.||.||:.|.|.|..:|:
  Rat    10 AAEAQPS------RSKQTRFCDGFKLFLAALSFSYICKALGGVVMKSSITQIERRFDIPSSISGL 68

  Fly   215 LLSASEMGQICTAMLLTYFAGRGHRPRWIACGMVLFSIAAFSCALPHFIFGEQLMHSSVILQQTQ 279
            :....|:|.:...:.::||..:.|||:.|..|..:..|.:...|||||..|..     ...::..
  Rat    69 IDGGFEIGNLLVIVFVSYFGSKLHRPKLIGIGCFIMGIGSILTALPHFFMGYY-----KYAKEND 128

  Fly   280 VSPPNNSFSSHWLNASSEQVNPNLCILGGNQTHSGSECNEERQLEQASHSKITVIVLCIFFGSLL 344
            :....||..:.::|..:....|:..|:             |:..|:...|.:.:.||   .|::|
  Rat   129 IGSLGNSTLTCFINQMTSPTGPSPEIV-------------EKGCEKGLKSHMWIYVL---MGNML 177

  Fly   345 SSGIGQTAVATLGIPYIDDNVGSKQSPMYMAVTIGMRILGPASGFIFGSFCTR-----WYVNFSN 404
             .|||:|.:..|||.|:||......:.|::.....:.::||..|||..|...:     .||:.::
  Rat   178 -RGIGETPIVPLGISYLDDFAKEGHTSMHLGTLHTIAMIGPILGFIMSSVFAKIYVDVGYVDLNS 241

  Fly   405 PGFDATDPRWIGAWWLGPVAIGSLMLLASIAMFSFPKQLRGKQKPPGQTATPAAPVEPEEKPKLK 469
            ......|.||:|||||..:..|.|.:.:||..|..||..:..|:....:.:..||...|||..:.
  Rat   242 VRITPNDARWVGAWWLSFIVNGLLCITSSIPFFFLPKIPKRSQEERKNSVSLHAPKTDEEKKHMT 306

  Fly   470 D--------------FPKTVRRQLSNDILMFRTASCVFHLLPIAGLYTFLPKYLETQFRLATYDA 520
            :              |.:::|..|:|:|.:......:..:....|.:|:|.|::|.||......|
  Rat   307 NLTKQEEQDPSNMTGFLRSLRSILTNEIYVIFLILTLLQVSGFIGSFTYLFKFIEQQFGRTASQA 371

  Fly   521 NMIAAFCGILVMGIGIVISGLFILKRKPTARGVAAWIAFTALVYSAGMIILMFIGCSMNDFAGYK 585
            |.:.....|..|...:.:.|..:.|.|.|:.|:|.::.||:.|..|...:...:.|....|||..
  Rat   372 NFLLGIITIPTMATAMFLGGYIVKKFKLTSVGIAKFVFFTSSVAYAFQFLYFPLLCENKPFAGLT 436

  Fly   586 PS-DGNSPA---LIEPTCSAALNCTCDKENFAPICAD-GKMYISACHAGCSSSSLRPSDNRTLYS 645
            .: ||.:|.   :..|......:|:|||..:.|||.: |..|||.|.|||.|.......|.|.:.
  Rat   437 LTYDGMNPVDSHIDVPLSYCNSDCSCDKNQWEPICGENGVTYISPCLAGCKSFRGDKKPNNTEFY 501

  Fly   646 DCACIPDA--PEAVNGYCDN-NCKNFIYFILIFAICV-FMHSTSEVGSMLLVMRCTHPKDKAMAM 706
            ||:||.::  ..|..|.|.. .||...||.:|..:.| |..:......:|::|:...|:.|::||
  Rat   502 DCSCISNSGNNSAHLGECPRYKCKTNYYFYIILQVTVSFFTAMGSPSLILILMKSVQPELKSLAM 566

  Fly   707 GVIQSAIGLFGNVPCPIIYGAVVDSACLIWK-SVCGKHGACSLYDADTFRQYFLGITAGI----M 766
            |.....|...|.:..||.|||.:|..|:.|. :.|||.|||.||::..|...:||:...:    :
  Rat   567 GFHSLIIRALGGILAPIYYGAFIDRTCIKWSVTSCGKRGACRLYNSRLFGFSYLGLNLALKTPPL 631

  Fly   767 FLAFLMDLVVWRKAHR-----IDIAPEDPQEGGPAS---NG 799
            ||..::.....||..|     ::...:...||.|.|   ||
  Rat   632 FLYVVLIYFTKRKYKRNDNKTLENGRQFTDEGNPDSVNKNG 672

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Oatp74D	NP_001163460.1	OATP	175..754	CDD:335235	171/607 (28%)
Slco1b2	NP_113838.1	MFS	28..555	CDD:421695	147/548 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	286..311		5/24 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3626
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1029129at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820