Protein Alignment Oatp74D and slco4a1

DIOPT Version :9

• Sequence 1: NP_001163460.1
• Gene: Oatp74D / 39954
• FlyBaseID: FBgn0036732
• Length: 819
• Species: Drosophila melanogaster
• Sequence 2: NP_001297061.1
• Gene: slco4a1 / 567865
• ZFINID: ZDB-GENE-060606-4
• Length: 742
• Species: Danio rerio
• Alignment Length: 849
• Identity: 223/849 - (26%)
• Similarity: 360/849 - (42%)
• Gaps: 203/849 - (23%)

  Fly    21 PSNGHGQLNGNGYHQNGGRRDSSQAFTPLLSQHNNGTTNGEVTTPPPSTVLYESTPSNNNEWKAP 85
            ||....|.:|:|       ..|..|.|||   ||.|....|:|.||
Zfish    32 PSPVESQGSGSG-------SPSGDAHTPL---HNTGKLGLELTDPP------------------- 67

  Fly    86 EDLGHLKNGLGNILSSNNNGTGNGHSLSEKYAHEQAPLTGGYKLPPRSSESEESDFDSDLNGGSS 150
                   |||..:.:.:.|                  |.|...|.||..::    |::
Zfish    68 -------NGLKFVPTDSEN------------------LCGWGALTPRCIQT----FNT------- 96

  Fly   151 AESSSSCGLFGCRPRWARRFASTHVFMVVFLL--AYILQGMYMTYFV-SVITTIEKLFQIKSKTT 212
                         |||           |:|.|  |..||||.:..|: :|||:||:...::|...
Zfish    97 -------------PRW-----------VLFFLCVASFLQGMIINGFINTVITSIERRLDLRSYQA 137

  Fly   213 GILLSASEMGQICTAMLLTYFAGRGHRPRWIACGMVLFSIAAFSCALPHFIFGEQLMHSSVILQQ 277
            |::.|:.::........::||.|.||:|||:..|:::.::.:...|||||           ....
Zfish   138 GLIASSYDIAACLCLTFVSYFGGTGHKPRWLGWGVLVMALGSLVFALPHF-----------TTPA 191

  Fly   278 TQVSPPNNSFSSHWLNASSEQVNPNLCILGGNQTHSGSECNEERQLEQASHSKITVIVLCIFFGS 342
            .||..|...               .||    ::.|:.:...||..|....:         :|...
Zfish   192 YQVRVPERM---------------GLC----SENHTETCVGEEGGLSAYRY---------VFMLG 228

  Fly   343 LLSSGIGQTAVATLGIPYIDDNVGSKQSPMYMAVTIGMRILGPASGFIFGSFCTRWYVNF-SNPG 406
            ....|:|.|.:.|||:.|:|:||.|..:|:|:.:.....|:|||:|::.|.|....|... ....
Zfish   229 QSLHGVGATPLYTLGVTYLDENVKSNYAPVYIGIFYTAAIVGPAAGYLLGGFFLNIYTEIGQTTE 293

  Fly   407 FDATDPRWIGAWWLGPVAIGSLMLLASIAMFSFPKQLRGKQKPPGQTATPAAPV---------EP 462
            ....:|.|:||||:|.:|.|:..||.::.:..:|:||.|.|:......:.|..:         :|
Zfish   294 LTPENPLWVGAWWIGFLAGGAAALLIALPILGYPRQLPGSQRYVAMRVSEAHQLKDGSQVTASDP 358

  Fly   463 EEKPKLKDFPKTVRRQLSNDILMFRTASCVFHLLPIAGLYTFLPKYLETQFRLATYDANMIAAFC 527
            :....:||.|:::...|.|...:|...:.......|||:.||.||:||:||.|:..:|   |.:.
Zfish   359 QFGKTVKDMPRSMLLLLKNPTFIFLCLAGATEATLIAGMSTFGPKFLESQFSLSASEA---ATWF 420

  Fly   528 GILVM---GIGIVISGLFILKRKPTARGVAAWIAFTALVYSAGMIILMFIGCSMNDFAG------ 583
            |.:|:   |.|..:.|..|.|.....||:..:....||| |...|.:..:.|.....||
Zfish   421 GYMVVPAGGGGTFLGGFIIKKLNLRCRGIIRFCMLCALV-SLMAIFIFLVHCPNVPMAGVTISYY 484

  Fly   584 -----------YKPSDGNSPA---LIEPTCSAALNCTCDKENFAPIC-ADGKMYISACHAGCSS- 632
                       |...|.::.:   |..||.:..:.|.|.:|:|.|:| |||.||.|.|||||||
Zfish   485 SNVTHNHNSALYLQKDKHNSSFSDLSNPTVACNIGCHCLEESFNPVCGADGVMYFSPCHAGCSSL 549

  Fly   633 -SSLRPSDNRTLYSDCACIP------DAPEAVNGYCDNNCKN---FIYFILIFAICVFMHSTSEV 687
             .:..|. .|.::|.|:|:.      :...|..|.|.::|.:   |:.|:.|..:..|:.|   :
Zfish   550 NHTFGPR-GRQVFSGCSCVAGNISWGEQGFAEEGRCVSSCNHMPAFLTFLFILILFTFLCS---I 610

  Fly   688 GSMLLVMRCTHPKDKAMAMGVIQSAIGLFGNVPCPIIYGAVVDSACLIWKSVCGKHGACSLYDAD 752
            .::...:||.....::..:|:....:...|.:|.||.:|:|:|.:||:|:..||::|:|.||...
Zfish   611 PALTATLRCVPDSQRSFGLGIQWIVVRTLGGIPGPIAFGSVIDISCLLWEEQCGEYGSCYLYHNS 675

  Fly   753 TFRQYFLGITAGIMF-----LAFLMDLVVWRKAHRIDIAPEDPQEGGPASNGRTLEVSESKQ-PI 811
            ...||  .:.|||::     ..||:..::::.      .||.||     |:..:.:|.|||. ||
Zfish   676 AMSQY--SLVAGIIYKVLGTFFFLLATLLYKP------PPESPQ-----SSCESTDVGESKDLPI 727

  Fly   812 TPAP 815
            ...|
Zfish   728 KDHP 731

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Oatp74D	NP_001163460.1	OATP	175..754	CDD:335235	174/626 (28%)
slco4a1	NP_001297061.1	OATP	99..677	CDD:281175	175/635 (28%)
		MFS	101..>285	CDD:119392	60/222 (27%)
		KAZAL_SLC21	512..567	CDD:238650	25/55 (45%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3626
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810