Protein Alignment Oatp74D and LOC556735

DIOPT Version :10

• Sequence 1: NP_648989.1
• Gene: Oatp74D / 39954
• FlyBaseID: FBgn0036732
• Length: 819
• Species: Drosophila melanogaster
• Sequence 2: XP_684701.3
• Gene: LOC556735 / 556735
• -ID: -
• Length: 859
• Species: Danio rerio
• Alignment Length: 798
• Identity: 221/798 - (27%)
• Similarity: 357/798 - (44%)
• Gaps: 178/798 - (22%)

  Fly   139 SDFDSDLNGGSSAESSSSCGLFGCRPRWARR-------------------------FASTHVFMV 178
            |:.||......|..:||..||.......|.|                         .:.:..|:
Zfish    82 SELDSPTRTDFSPSASSMVGLSSSMRTEANRAGGKKLGFSLARLIRFPVRKYLRVILSDSRCFL- 145

  Fly   179 VFLLAYI--LQGMYMT-YFVSVITTIEKLFQIKSKTTGILLSASEMGQICTAMLLTYFAGRGHRP 240
             |.:.|:  :|.:.:: |..||||||||.:.::|..:|:|:|..::|.:...:.::||.|||.||
Zfish   146 -FCMCYLTFIQSLMVSGYLSSVITTIEKRYSLRSSESGLLVSCFDIGSLLVVVFISYFGGRGQRP 209

  Fly   241 RWIACGMVLFSIAAFSCALPHFIFGEQLMHSSVILQQTQVSPPNNSFSSHWLNASSEQVNPNLCI 305
            ||:|.|.|..::.|...:|||||                 |||   :....:|:|  ..|..||
Zfish   210 RWLAVGGVFIAVGAALFSLPHFI-----------------SPP---YQIKEVNSS--MGNEGLC- 251

  Fly   306 LGGNQTHSG---SECNEERQLEQASHSKITVIVLCIFFGSLLSSGIGQTAVATLGIPYIDDNVGS 367
            |.||::...   |.|  .|..|...||    |.:.:|..:.:..|:|.|.:.|||..|:||||..
Zfish   252 LNGNRSRDALDVSSC--PRDQEGNDHS----IYVALFVCAQVLVGMGSTPIYTLGPTYLDDNVKK 310

  Fly   368 KQSPMYMAVTIGMRILGPASGFIFGSFCTRWYVNFSNP----GFDATDPRWIGAWWLGPVAIGSL 428
            :.:.:|:|:...|..||||:|::.|.....:||   :|    ..:.:|||::|.||.|.:.....
Zfish   311 ENASLYLAIMYVMGALGPAAGYLLGGVLIGFYV---DPKTIVNIEQSDPRFVGNWWSGFLLCAFA 372

  Fly   429 MLLASIAMFSFPKQL--RGKQKPPGQTATPAAPVEPE---EKPK---------------LKDFPK 473
            |||....||:|||:|  |.|:|.....|..|:..:.:   ||..               :||.||
Zfish   373 MLLVIFPMFTFPKKLPPRHKKKKKKHAADSASNDDDDVLKEKSNSKGQTVASSMGFGRDIKDLPK 437

  Fly   474 TVRRQLSNDILMFRTASCVFHLLPIAGLYTFLPKYLETQFRLATYDANMIAAFCGILVM---GIG 535
            ...|.|||...:|.:.|.......:....||:||::|:||.:...:|::   :.|::::   |:|
Zfish   438 AAIRILSNMTFLFVSLSYTAESAIVTAFITFIPKFIESQFGIPASNASI---YTGVIIVPSAGVG 499

  Fly   536 IVISGLFILKRKPTARGVAAWIAFTALVYSAGMIILMF-----IGCSMNDFAGYKPSDGNSPALI 595
            ||:.|..|.|.|..||..|.    .|::.| |:.:|.|     :||...:..|.     |.|...
Zfish   500 IVLGGYIIKKLKLGARESAK----LAMICS-GVSLLCFSTLFIVGCESINLGGI-----NIPYTT 554

  Fly   596 EPTCSAA---------LNCTCDKENFAPIC-ADGKMYISACHAGCS-----SSSLRPSDNRTLYS 645
            .||.:..         :||.|....:||:| :||..|.:.|.||||     |:.:|.      |:
Zfish   555 GPTLTLTHRNLTGGCNVNCGCRINEYAPVCGSDGITYFNPCLAGCSTVGNDSTGIRN------YT 613

  Fly   646 DCACI--------PDAPE------------------AVNGYCDNNCKNFIYFILIFAICVFMHST 684
            ||||:        |.:.:                  |::|.||..|...|.|::...|...:.:.
Zfish   614 DCACVQSRQVITPPTSGQGNQLQLVIVKTYLNENGFALSGKCDRTCNTLIPFLIFLFIVTLITAC 678

  Fly   685 SEVGSMLLVMRCTHPKDKAMAMGVIQSAIGLFGNVPCPIIYGAVVDSACLIWKSVCGKHGACSLY 749
            ::..::::.:|....:::..|:|:....:.....:|.||.:|||:|:.|::|:..||.||:|..|
Zfish   679 AQPSAIIVTLRSVDEQERPFALGMQFVLLRTLAYIPTPIYFGAVIDTTCMLWQQDCGIHGSCWEY 743

  Fly   750 DADTFRQYFLGITAGIMFLAFLMDLVVW----RKAHRI-----------DIAPEDPQEGGPASNG 799
            |..:||..:.|:.|.:.|:.|:...:.|    .|..|:           .::......||..|:.
Zfish   744 DVTSFRFVYFGLAASLKFVGFIFIFLTWYSIKYKEDRLKRWQQHLPPLGTVSELICHAGGHKSHA 808

  Fly   800 RTLEVSESKQPI-TPAPD 816
            ||...     || ||.|:
Zfish   809 RTRSC-----PIFTPRPE 821

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Oatp74D	NP_648989.1	OATP	175..754	CDD:460821	192/657 (29%)
LOC556735	XP_684701.3	MFS_SLCO5_OATP5	142..689	CDD:340962	173/599 (29%)